Psoriasis Clinical Trial
Safety and Efficacy of Secukinumab Compared to Etanercept in Subjects With Moderate to Severe, Chronic Plaque-Type Psoriasis
Summary
This study will assess the safety and efficacy of secukinumab compared to placebo and etanercept in patients that have moderate to severe, chronic, plaque-type psoriasis.
Eligibility Criteria
Inclusion Criteria:
Subjects with chronic, plaque-type psoriasis for at least 6 months
Must have moderate to severe psoriasis based on PASI greater than 12, IGA greater than 3, and greater than 10% body surface area
Must be inadequately controlled by prior treatments (topicals, phototherapy, and/or systemic therapies)
Exclusion Criteria:
Forms of psoriasis other than chronic, plaque-type (such as pustular, erythrodermic and guttate psoriasis)
Drug induced psoriasis
Use of other psoriasis treatments during the study
Prior use of etanercept
Prior use of secukinumab or any other drug that target IL-17 (interleukin 17) or the IL-17 receptor
Pregnant or lactating women; women who do not agree to use contraception during the study and for 16 weeks after stopping treatment
Significant medical problems such as uncontrolled high blood pressure, congestive heart failure, etc.
History of an ongoing, chronic or recurrent infection or evidence of tuberculosis
Allergy to rubber or latex
Other protocol-defined inclusion/exclusion criteria may apply
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There are 146 Locations for this study
Birmingham Alabama, 35205, United States
Phoenix Arizona, 85013, United States
San Diego California, 92103, United States
San Diego California, 92123, United States
Indianapolis Indiana, 46256, United States
High Point North Carolina, 27262, United States
Warren Ohio, 44483, United States
Portland Oregon, 97210, United States
Johnston Rhode Island, 02919, United States
Charleston South Carolina, 29407, United States
Kingsport Tennessee, 37660, United States
San Antonio Texas, 78229, United States
Norfolk Virginia, 23507, United States
Caba Buenos Aires, C1062, Argentina
Caba Buenos Aires, C1114, Argentina
Caba Buenos Aires, C1181, Argentina
Caba Buenos Aires, C1425, Argentina
Caba Capital Federal, , Argentina
Buenos Aires , C1425, Argentina
Mendoza , M5502, Argentina
Kogarah New South Wales, 2217, Australia
Woolloongabba Queensland, 4102, Australia
Carlton Victoria, 3053, Australia
East Melbourne Victoria, 3002, Australia
Brussel , 1090, Belgium
Bruxelles , 1200, Belgium
Gent , 9000, Belgium
Liège , 4000, Belgium
Edmonton Alberta, T5K 1, Canada
Surrey British Columbia, V3V 0, Canada
Vancouver British Columbia, V5Z 4, Canada
Halifax Nova Scotia, B3H 1, Canada
Markham Ontario, L3P 1, Canada
Richmond Hil Ontario, L4B 1, Canada
Waterloo Ontario, N2J 1, Canada
Sainte-Foy Quebec, G1V 4, Canada
Barranquilla , , Colombia
Bogotá , , Colombia
Bucaramanga , , Colombia
Alexandria , 21131, Egypt
Helsinki , 00250, Finland
Turku , FIN-2, Finland
Marseille Cedex 9 , 13913, France
Martigues , 13500, France
Nice Cedex 3 , 06202, France
Paris , 75475, France
Pessac Cedex , 33604, France
Reims , 51092, France
Toulouse Cedex , 31059, France
Augsburg , 86179, Germany
Berlin , 10117, Germany
Berlin , 10827, Germany
Berlin , 13187, Germany
Bielefeld , 33647, Germany
Bochum , 44791, Germany
Bochum , 44803, Germany
Bonn , 53105, Germany
Darmstadt , 64283, Germany
Dresden , 01307, Germany
Erfurt , 99089, Germany
Erlangen , 91052, Germany
Essen , 45122, Germany
Frankfurt , 60590, Germany
Gera , 07548, Germany
Goettingen , 37075, Germany
Greifswald , 17475, Germany
Hamburg , 20354, Germany
Hamburg , 22143, Germany
Hamburg , 22391, Germany
Hanau , 63450, Germany
Heidelberg , 69115, Germany
Kiel , 24105, Germany
Krefeld , 47805, Germany
Köln , 50937, Germany
Muenster , 48149, Germany
München , 80802, Germany
Nuernberg , 90419, Germany
Osnabrück , 49074, Germany
Plauen , 08529, Germany
Recklinghausen , 45657, Germany
Regensburg , 93053, Germany
Schwerin , 19055, Germany
Tuebingen , 72076, Germany
Witten , 58452, Germany
Wuppertal , 42275, Germany
Guatemala City , 01010, Guatemala
Guatemala City , 01015, Guatemala
Budapest , 1036, Hungary
Budapest , 1134, Hungary
Debrecen , 4032, Hungary
Kaposvár , 7400, Hungary
Miskolc , 3529, Hungary
Szeged , H-672, Hungary
Szombathely , 9700, Hungary
Kopavogur , IS-20, Iceland
Hyderabad Andhra Pradesh, 50000, India
Hyderabad Andhra Pradesh, 50001, India
Vishakhapatnam Andhra Pradesh, 532 0, India
Bangalore Karnataka, 40003, India
Bangalore Karnataka, 56000, India
Bangalore Karnataka, 56000, India
Mangalore Karnataka, 57500, India
Dadar (east) Mumbai Maharashtra, 40001, India
Mumbai Maharashtra, 400 0, India
Nagpur Maharashtra, 44001, India
Dehli New Delhi, 110 0, India
Hyderabad , 50004, India
L'Aquila AQ, 67100, Italy
Catania CT, 95123, Italy
Genova GE, 16132, Italy
Terracina LT, 04019, Italy
Modena MO, 41100, Italy
Roma RM, 00167, Italy
Napoli , 80131, Italy
Anyang Gyeonggi-do, 431-0, Korea, Republic of
Seoul Korea, 135-7, Korea, Republic of
Busan , 602-7, Korea, Republic of
Daejeon , 301-7, Korea, Republic of
Gwangju , 501-5, Korea, Republic of
Seoul , 120-7, Korea, Republic of
Seoul , 137-7, Korea, Republic of
Seoul , 143-7, Korea, Republic of
Seoul , 156-7, Korea, Republic of
Seoul , 738-7, Korea, Republic of
Las Pinas , 1740, Philippines
Manila , 1000, Philippines
Lodz , 90-26, Poland
Lodz , 90-43, Poland
Poznan , 60-52, Poland
Wroclaw , 50-36, Poland
Bucuresti , 01146, Romania
Bucuresti , 02110, Romania
Bucuresti , 04133, Romania
Bucuresti , 06227, Romania
Singapore , 11907, Singapore
Sabadell Barcelona, 08208, Spain
Santa Coloma De Gramanet Cataluña, 08923, Spain
Valencia Comunidad Valenciana, 46014, Spain
Barcelona , 08025, Spain
Madrid , 28031, Spain
Madrid , 28041, Spain
Göteborg , 413 4, Sweden
Luleå , 972 3, Sweden
Malmo , SE-20, Sweden
Uppsala , 751 8, Sweden
Plymouth Devon, PL6 8, United Kingdom
Salford Manchester, M6 8H, United Kingdom
Yeovil Somerset, BA21 , United Kingdom
Dudley , DY1 2, United Kingdom
Harrogate , HG2 7, United Kingdom
London , E11 1, United Kingdom
Nuneaton , CV10 , United Kingdom
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