Psoriasis Clinical Trial

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Tofacitinib In Psoriatic Arthritis Subjects With Inadequate Response to TNF Inhibitors

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Summary

To examine the safety and efficacy of tofacitinib in subjects with active psoriatic arthritis who have previously had an inadequate response to at least one TNF inhibitor either due to lack of efficacy or an adverse event.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Active arthritis at screening/baseline as indicated by >/= 3 tender/painful and 3 swollen joints
Active plaque psoriasis at screening
Inadequate efficacy or lack of toleration to previously administered TNF inhibitor

Exclusion Criteria:

Non-plaque forms of psoriasis (with exception of nail psoriasis)
History of autoimmune rheumatic disease other than PsA; also prior history of or current, rheumatic inflammatory disease other than PsA

Study is for people with:

Psoriasis

Phase:

Phase 3

Estimated Enrollment:

395

Study ID:

NCT01882439

Recruitment Status:

Completed

Sponsor:

Pfizer

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There are 110 Locations for this study

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Rheumatology Associates P.C.
Birmingham Alabama, 35205, United States
Rheumatology Associates of North Alabama, PC
Huntsville Alabama, 35801, United States
Arizona Arthritis & Rheumatology Associates, P.C.
Glendale Arizona, 85306, United States
Medvin Clinical Research
Covina California, 91723, United States
St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare
Fullerton California, 92835, United States
Ronald Reagan UCLA Medical Center, Drug Information Center
Los Angeles California, 90095, United States
UCLA David Geffen School of Medicine
Los Angeles California, 90095, United States
San Diego Arthritis Medical Clinic
San Diego California, 92108, United States
Stanford Hospital and Clinics
Stanford California, 94305, United States
New England Research Associates, LLC
Trumbull Connecticut, 06611, United States
Rheumatology Associates of Central Florida, PA
Orlando Florida, 32806, United States
Millennium Research
Ormond Beach Florida, 32174, United States
Arthritis Center, Inc.
Palm Harbor Florida, 34684, United States
Integral Rheumatology & Immunology Specialists (IRIS)
Plantation Florida, 33324, United States
Florida Medical Clinic, P.A.
Zephyrhills Florida, 33542, United States
St. Luke's Clinic - Rheumatology
Boise Idaho, 83702, United States
St. Luke's Intermountain Research Center
Boise Idaho, 83702, United States
Bluegrass Community Research, Inc
Lexington Kentucky, 40504, United States
Klein & Associates, M.D., P.A.
Hagerstown Maryland, 21740, United States
The Center For Rheumatology And Bone Research
Wheaton Maryland, 20902, United States
Brigham & Women's Hospital
Boston Massachusetts, 02115, United States
Brigham and Women's Hospital
Boston Massachusetts, 02115, United States
Clinical Pharmacology Study Group
Worcester Massachusetts, 01605, United States
St. Paul Rheumatology, PA
Eagan Minnesota, 55121, United States
Clayton Medical Research
Saint Louis Missouri, 63117, United States
Physician Research Collaboration, LLC
Lincoln Nebraska, 68516, United States
Dartmouth-Hitchcock Medical Center (DHMC)
Lebanon New Hampshire, 03756, United States
Cincinnati Rheumatic Disease Study Group, Inc.
Cincinnati Ohio, 45219, United States
University Hospitals Case Medical Center
Cleveland Ohio, 44106, United States
Paramount Medical Research & Consulting, LLC
Middleburg Heights Ohio, 44130, United States
East Penn Rheumatology Associates, PC
Bethlehem Pennsylvania, 18015, United States
Altoona Center for Clinical Research
Duncansville Pennsylvania, 16635, United States
Low Country Rheumatology, PA
Charleston South Carolina, 29406, United States
Arthritis Clinic
Jackson Tennessee, 38305, United States
West Tennessee Research Institute
Jackson Tennessee, 38305, United States
Adriana M. Pop-Moody, M.D., Clinic, P.A.
Corpus Christi Texas, 78404, United States
Pioneer Research Solutions, Inc.
Cypress Texas, 77429, United States
Metroplex Clinical Research Center
Dallas Texas, 75231, United States
Drug Shipment/Storage: Investigational Drug Services
Salt Lake City Utah, 84112, United States
University of Utah Hospital & Clinics
Salt Lake City Utah, 84132, United States
Dynacare Laboratories
Seattle Washington, 98122, United States
Seattle Rheumatology Associates
Seattle Washington, 98122, United States
Swedish Medical Center
Seattle Washington, 98122, United States
Royal Prince Alfred Hospital, Rheumatology Department
Camperdown New South Wales, 2050, Australia
Rheumatology Research Unit
Maroochydore Queensland, 4558, Australia
Emeritus Research Pty Ltd
Malvern East Victoria, 3145, Australia
Hospital Erasme - Clinique Universitaire de Bruxelles
Brussels , 1070, Belgium
ReumaClinic
Genk , 3600, Belgium
Universitair Ziekenhuis Gent
Gent , 9000, Belgium
University Hospital Leuven, Department of Rheumatology
Leuven , 3000, Belgium
ZNA Jan Palfijn
Merksem , 2170, Belgium
CMIP: Centro Mineiro de Pesquisa Ltda /
Juiz de Fora MG, 36010, Brazil
CETAC - DIAGNOSTICO POR IMAGEM (image only)
Curitiba PR, 80240, Brazil
EDUMED - Educacao em Saude SS LTDA.
Curitiba PR, 80440, Brazil
Hospital de Clinicas de Porto Alegre (HCPA) / UFRGS
Porto Alegre RS, 90035, Brazil
Clinica Medica Bonfiglioli Ltda. / Clinica Bonfiglioli
Campinas SP, 13015, Brazil
Radiologia Clínica de Campinas - RCC (Images only)
Campinas São Paulo, 13015, Brazil
Medical Plus s.r.o.
Uherske Hradiste , 68601, Czechia
Centre Hospitalier Sud-Francilien - Secretariat de Rhumatologie
Corbeil-Essonnes Cedex, 91106, France
Hopital Avicenne
Bobigny , 93000, France
Rheumazentrum Prof. Dr. med Gunther Neeck
Bad Doberan , 18209, Germany
Charite Universitatsmedizin Berlin - Campus Charite Mitte
Berlin , 10117, Germany
Rheumapraxis Steglitz
Berlin , 12161, Germany
Schlosspark-Klinik
Berlin , 14059, Germany
Universitaetsklinikum Erlangen, Medizinische Klinik 3
Erlangen , 91054, Germany
CIRI - Centrum für innovative Diagnostik und Therapie Rheumatologie/Immunologie (GmbH)
Frankfurt am Main , 60528, Germany
Medizinische Universitatsklinik Freiburg
Freiburg , 79106, Germany
Universitaetsklinikum Des Saarlandes Und Medizinische Fakultaet Der Universitaet Des Saarlandes
Homburg , 66421, Germany
University Hospital of Cologne
Koeln , 50937, Germany
Elisabeth Klinik Bigge
Olsberg , 59939, Germany
Hospital Angeles Clinica Londres
Mexico City D.F, 06700, Mexico
Grupo Medico Camino S.C.
Mexico City Distrito Federal, 03310, Mexico
CLIDITER, S.A. de C.V.
Mexico Distrito Federal, 06700, Mexico
Universidad La Salle AC
Mexico Distrito Federal, 14000, Mexico
Medica Sur, S.A.B. de C.V. (For Emergencies Only)
Mexico Distrito Federal, 14050, Mexico
Centro Integral en Reumatologia SA de CV
Guadalajara Jalisco, 44160, Mexico
Grupo Santa Bernardette S.A. de C.V.
Guadalajara Jalisco, 44200, Mexico
Centro de Investigacion de Tratamientos Innovadores de Sinaloa, S.C
Culiacan Sinaloa, 80000, Mexico
Sanatorio CEMSI Chapultepec (For Emergencies Only)
Culiacan Sinaloa, 80040, Mexico
Hospital General de Culiacan "Dr. Bernardo J. Gastelum"
Culiacan Sinaloa, 80230, Mexico
Star Medica S.A. de C.V. (For Emergencies Only)
Merdia Yucatan, 97133, Mexico
Institute Medico Panamericano, S.A. de C.V. (For Emergencies Only)
Merida Yucatan, 97000, Mexico
Unidad Reumatologica Las Americas SCP
Merida Yucatan, 97000, Mexico
Centro de Investigacion Clinica Pensiones
Merida Yucatan, 97070, Mexico
Centro Multidisciplinario para el Desarrollo
Merida Yucatan, 97130, Mexico
Hospital Star Medica Merida (For Emergencies Only)
Merida Yucatan, 97133, Mexico
Christus Muguerza del parque, S.A de C.V
Chihuahua , 31000, Mexico
Investigacion y Biomedicina de Chihuahua
Chihuahua , 31000, Mexico
Centrum Kliniczno-Badawcze J.Brzezicki, B.Gornikiewicz-Brzez
Elblag , 82-30, Poland
Centrum Radiologii for X-Ray only
Elblag , 82-30, Poland
NZOZ Centrum Reumatologiczne Indywidualna Specjalistyczna Praktyka Lekarska Lek. Med. Barbara Bazela
Elblag , 82-30, Poland
Wojewodzki Szpital Zespolony Zaklad Radiologii
Elblag , 82-30, Poland
Przychodnia Specjalistyczna Lekarskiej Spozielni Pracy "Medica" for X-Ray Only
Grodzisk Mazowiecki , 05-82, Poland
Specjalistyczne Gabinety Lekarskie "DERMED" Anna Kaszuba
Lodz , 90-26, Poland
NZOZ Lecznica MAK-MED S.C.
Nadarzyn , 05-83, Poland
Prywatna Praktyka Lekarska Prof. UM dr hab. Pawel Hrycaj
Poznan , 61-39, Poland
Reumatika Centrum Reumatologii nzoz
Warszawa , 02-69, Poland
Regional State Budgetary Healthcare Institution of Karelia Republic "Republic Hospital n.a.
Petrozavodsk Karelia Republic, 18501, Russian Federation
State Autonomic Healthcare Institution City Clinical Hospital # 7
Kazan Republic of Tatarstan, Russia, 42010, Russian Federation
SBIH of Moscow "City Clinical Hospital#1 n. a. N.I. Pirogov" of the Healthcare Department of Moscow
Moscow , 11904, Russian Federation
City Neurological Centre "SibNeyroMed", LLC
Novosibirsk , 63009, Russian Federation
Limited Liability Company Consultative Diagnostic Rheumatology Center "Healthy Joints"
Novosibirsk , 63009, Russian Federation
State Budget Educational Institution of Highest Professional Education
Tomsk , 63405, Russian Federation
State Institution of Healthcare of Yaroslavl Region
Yaroslavl , 15000, Russian Federation
MEDMAN s.r.o. - reumatologicka ambulancia
Martin , 036 0, Slovakia
Hospital Clinico de Santiago
Santiago De Compostela A Coruna, 15706, Spain
Corporacio Sanitaria Parc Tauli
Sabadell Barcelona, 08208, Spain
Hospital Universitario Marques de Valdecilla
Santander Cantabria, 39008, Spain
Hospital Sierrallana
Torrelavega Cantabria, 39300, Spain
Complejo Hospitalario Universitario A Coruna
A Coruna , 15006, Spain
Hospital Universitari Vall d'Hebron
Barcelona , 08035, Spain
Hospital Universitario Virgen Macarena
Sevilla , 41009, Spain
Hospital Universitaro Y Politecnico La Fe
Valencia , 46026, Spain
Taipei Veterans General Hospital
Taipei Taiwan Roc, 11217, Taiwan
Buddhist Dalin Tzu Chi General Hospital
Chia-Yi , 62247, Taiwan
Chang Gung Medical Foundation-Kaohsiung Branch
Kaohsiung City , 83301, Taiwan
Chung Shan Medical University Hospital
Taichung , 40201, Taiwan
China Medical University Hospital
Taichung , 40447, Taiwan
Barking Havering and Redbridge University Hospitals NHS Trust
Goodmayes Essex, IG3 8, United Kingdom
Barking, Havering and Redbridge University Hospitals NHS Trust
Romford Essex, RM7 0, United Kingdom
The Dudley Group NHS Foundation Trust
Dudley West Midlands, DY1 2, United Kingdom
Bradford Royal Infirmary, BTHFT
Bradford West Yorkeshire, BD9 6, United Kingdom
Royal United Hospitals NHS Foundation Trust
Bath , BA1 1, United Kingdom
Bradford Teaching Hospitals NHS Foundation Trust
Bradford , BD5 0, United Kingdom
York Hospital, York Teaching Hospital NHS Foundation Trust
York , YO31 , United Kingdom
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How clear is this clinincal trial information?

Study is for people with:

Psoriasis

Phase:

Phase 3

Estimated Enrollment:

395

Study ID:

NCT01882439

Recruitment Status:

Completed

Sponsor:


Pfizer

How clear is this clinincal trial information?

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