Trial of an Injectable Biologic and U0279 as Combination Therapy for Severe Plaque-Type Psoriasis

Inclusion Criteria:

Male or female subjects 18 years of age or older.
Surgically sterile females. Females who have had a hysterectomy or completed menopause are allowed.
Affected Body Surface Area with psoriasis of ≥10%.
Psoriasis Global Assessment rating of "moderate to severe" or "severe".
Achieved mild to moderate improvement after receiving an injectable biologic therapy for at least 12 weeks.
A PASI score of ≥ 50 and ≤75
Capable of understanding and willing to provide signed and dated written voluntary informed consent (and any local or national authorization requirements) before any protocol specific procedures are performed

Exclusion Criteria:

Understand that the sponsor can not pay for the an injectable biologic therapy during the course of the study; be willing to pay out of pocket or secure payment through their private health insurance for an injectable biologic.
History of systemic infection, or other conditions that may interfere with study evaluations or may increase risk for participation. such as, tuberculosis, human immunodeficiency virus (HIV), hepatitis; congestive heart failure or demyelinating disorder.
Used of prohibited medications or therapies