Acute Myeloid Leukemia Clinical Trial

Characterization of T-cell Repertoire in Patients With Acute Myeloid Leukemia Undergoing Donor Stem Cell Transplant

Summary

This research trial studies characterization of T-cell repertoire through next-generation sequencing in patients with acute myeloid leukemia undergoing stem cell transplant. Characterizing T-cell repertoire may help to understand if immune system plays a significant role in high risk patients with acute myeloid leukemia.

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Full Description

PRIMARY OBJECTIVES:

I. Characterize the T cell receptor (TCR) repertoire in acute myeloid leukemia (AML) patients before and after receiving hematologic stem cell transplantation (HSCT).

II. Identify molecular changes (germline variants and somatic mutations) that contribute to shaping the TCR repertoire.

OUTLINE:

Patents undergo collection of blood samples before, on day 100, and 1 year after HSCT. Donors undergo collection of blood at the time of HSCT for ribonucleic acid (RNA)-based next generation sequencing of TCRA and TCRB genes.

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Eligibility Criteria

Inclusion Criteria:

Diagnosis of AML scheduled to undergo HSCT at University of Southern California (USC)

Exclusion Criteria:

Inability to provide consent because of severe mental disorders
Donor unwilling to provide consent

Study is for people with:

Acute Myeloid Leukemia

Estimated Enrollment:

200

Study ID:

NCT03921047

Recruitment Status:

Recruiting

Sponsor:

University of Southern California

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There is 1 Location for this study

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USC / Norris Comprehensive Cancer Center
Los Angeles California, 90033, United States More Info
Houda Alachkar
Contact
323-442-2696
[email protected]
Houda Alachkar
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Acute Myeloid Leukemia

Estimated Enrollment:

200

Study ID:

NCT03921047

Recruitment Status:

Recruiting

Sponsor:


University of Southern California

How clear is this clinincal trial information?

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