Acute Myeloid Leukemia Clinical Trial

Metabolic Changes in Blood Samples From Patients With Acute Myeloid Leukemia

Summary

This research trial studies metabolic changes in blood samples from patients with acute myeloid leukemia. Studying samples of blood from patients with acute myeloid leukemia in the laboratory may help doctors learn more about cancer and the development of drug resistance.

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Full Description

PRIMARY OBJECTIVES:

I. To determine the metabolic adaptations that occur following exposure to standard chemotherapeutic agents using peripheral blood mononuclear cells from acute myeloid leukemia (AML) patients.

OUTLINE:

Patients undergo collection of peripheral blood mononuclear cell (PBMC) samples for analysis via cell isolation, glycolytic flux and oxygen consumption assays, viability assays, and western blot at baseline, 24, 48, and 72 hours after starting chemotherapy.

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Eligibility Criteria

Inclusion Criteria:

Patients scheduled to initiate chemotherapy for either an initial diagnosis of AML or relapsed AML
Starting the initial induction phase of therapy
Exposure to hydroxyurea is acceptable but must be noted at the time of sample collection
Ability to understand and the willingness to sign an institutional review board (IRB)-approved informed consent

Exclusion Criteria:

Received at least one dose of chemotherapy during the current cycle (excluding hydroxyurea).

Study is for people with:

Acute Myeloid Leukemia

Estimated Enrollment:

14

Study ID:

NCT02581917

Recruitment Status:

Completed

Sponsor:

Wake Forest University Health Sciences

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There is 1 Location for this study

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Comprehensive Cancer Center of Wake Forest University
Winston-Salem North Carolina, 27157, United States

How clear is this clinincal trial information?

Study is for people with:

Acute Myeloid Leukemia

Estimated Enrollment:

14

Study ID:

NCT02581917

Recruitment Status:

Completed

Sponsor:


Wake Forest University Health Sciences

How clear is this clinincal trial information?

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