Acute Myeloid Leukemia Clinical Trial
Study of ProTmune for Allogeneic HCT in Adult Patients With Hematologic Malignancies
This study is a Phase 1, Non-randomized, Open-label/Phase 2 Randomized, Blinded Study of ProTmune (ex vivo programmed mobilized peripheral blood cells) Versus Non-programmed mobilized peripheral blood cells for Allogeneic Hematopoietic Cell Transplantation (HCT) in Adult Subjects Aged 18 years and older with Hematologic Malignancies. A maximum of 80 total eligible subjects will be enrolled and treated in the trial at approximately 15-20 centers in the US.
Key Inclusion Criteria:
Male and female patients aged 18 years and older, inclusive;
Patients must have a hematologic malignancy for which allogeneic hematopoietic peripheral blood cell transplantation is deemed clinically appropriate.
Eligible diseases and stages include the following:
Acute myeloid leukemia
Acute lymphoblastic leukemia, including T lymphoblastic lymphoma with a history of marrow involvement
Chronic myelogenous leukemia
Availability of a suitable 8/8 HLA-A, -B, -C, and -DRB1-matched unrelated mPB donor;
mBP donor collection that meets protocol specifications;
Adequate performance status, defined as Karnofsky score greater than or equal to 70%;
For female patients of childbearing potential, all of the following criteria must be met:
They are not pregnant (i.e., female patients must have a negative serum pregnancy test at screening);
They are not breastfeeding;
They do not plan to become pregnant during the study; and
They are using an effective method of contraception from screening to the end of the study, unless their sexual partner is surgically sterile.
For male patients, agreement to use condoms with spermicide during sexual intercourse from screening to the end of study; and
Willingness and ability to sign an IRB/IEC-approved ICF before performance of any study-specific procedures or tests and to comply with protocol visits, and study procedures.
Key Exclusion Criteria:
Phase 1 only: Known bone marrow fibrosis; Phase 2 only: Bone marrow fibrosis grade 3 (severe) or greater;
Positive serology for human immunodeficiency virus (HIV) or human T-cell lymphotropic virus (HTLV) at any time prior to enrollment;
Currently uncontrolled bacterial, viral, or fungal infection (progression of clinical symptoms despite therapy);
Prior autologous or allogeneic HCT;
Active malignancy, other than the one for which the allogeneic mPB transplant is being performed, within 12 months of enrollment, excluding superficial basal cell and carcinoma in situ cervical cancer;
Pulmonary disease, renal dysfunction, hepatic disease, cardiac disease, neurologic disease;
Participation in another clinical trial involving an investigational product within 30 days prior to screening; or
Any condition or therapy, which, in the opinion of the Investigator, might pose a risk to the patient or make participation in the study not in the best interest of the patient.
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There are 8 Locations for this study
Birmingham Alabama, , United States
Duarte California, 91010, United States
San Diego California, , United States
Chicago Illinois, , United States
Indianapolis Indiana, 46237, United States
Boston Massachusetts, 02215, United States
Detroit Michigan, 48201, United States
New York New York, , United States
Cincinnati Ohio, , United States
Columbus Ohio, 43210, United States
Portland Oregon, , United States
Nashville Tennessee, 37203, United States
San Antonio Texas, , United States
Salt Lake City Utah, 84103, United States
Richmond Virginia, 23298, United States
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