Bladder Cancer Clinical Trial

Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676)

Summary

This study is designed to assess the antitumor efficacy and safety of pembrolizumab in combination with BCG, compared to BCG monotherapy, in participants with HR NMIBC that is either persistent or recurrent following adequate BCG induction (Cohort A), or that is naïve to BCG treatment (Cohort B). The primary hypothesis for Cohort A is that the combination of pembrolizumab plus BCG has a superior complete response rate (CRR) as assessed by central pathology review compared to BCG in participants with carcinoma in situ (CIS). The primary hypothesis for Cohort B is that the combination of pembrolizumab plus BCG (either reduced maintenance or full maintenance) has a superior Event Free Survival (EFS) compared to BCG.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Have locally and blinded independent central review (BICR)-confirmed histological diagnosis of high-risk non-muscle invasive (T1, high grade Ta and/or CIS) UC of the bladder
Has undergone cystoscopy/ transurethral resection of bladder tumor (TURBT) to remove all resectable disease
Has provided tissue for biomarker analysis
Has Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2
Has adequate organ function
During the treatment period and for ≥7 days after the last dose of BCG, male participants are EITHER abstinent from heterosexual intercourse as their preferred and usual lifestyle and agree to remain abstinent, OR, must agree to use contraception unless confirmed to be azoospermic
Female participants who are not pregnant, not breastfeeding, and either not a woman of child bearing potential (WOCBP); or are a WOCBP who agrees to use a contraception method that is highly effective or remains abstinent from heterosexual intercourse during the treatment period and for ≥7 days after the last dose of BCG or 120 days after the last dose of pembrolizumab, whichever comes last

BCG Post-induction Cohort (Cohort A) Only

Has been treated with one adequate course of BCG induction therapy for the treatment of HR NMIBC
Following adequate BCG induction therapy, must have persistent or recurrent HR NMIBC

Exclusion Criteria:

Has a history of or concurrent locally advanced (i.e., T2, T3, T4) or metastatic UC
Has concurrent extra-vesical (i.e, urethra, ureter, renal pelvis) non-muscle invasive urothelial carcinoma or a history of extra-vesical non-muscle invasive UC
Has received prior therapy with anti-PD-1, anti-PD-L1, or anti-PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor
Has received prior systemic anti-cancer therapy including investigational agents within 4 weeks of start of study treatment
Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks of start of study treatment
Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy or any other form of immunosuppressive therapy within 7 days of start of study treatment
Has a known additional malignancy that is progressing or requires active treatment within the past 3 years
Has an active autoimmune disease that has required systemic treatment in past 2 years
Has a history of (non-infectious) pneumonitis/interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease
Has one or more of the following contraindications to BCG: prior BCG sepsis or systemic infection, total bladder incontinence, or an adverse experience to a previous BCG instillation that resulted in treatment discontinuation and precludes retreating with BCG
Has an active infection or diagnosis requiring systemic antimicrobial therapy
Has a known history of human immunodeficiency virus (HIV) infection
Has a known history of Hepatitis B or known active Hepatitis C virus infection
Has current active tuberculosis
Has had an allogenic-tissue/solid organ transplant
Has any contraindication(s) to IV contrast or is otherwise unable to have screening imaging with IV contrast performed

BCG Post-induction Cohort (Cohort A) Only - Has persistent T1 disease following an induction course of BCG

BCG Naïve Cohort (Cohort B) Only

- Has received any prior treatment with BCG for their NMIBC within the past 2 years prior to study entry

Study is for people with:

Bladder Cancer

Phase:

Phase 3

Estimated Enrollment:

1405

Study ID:

NCT03711032

Recruitment Status:

Recruiting

Sponsor:

Merck Sharp & Dohme LLC

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There are 173 Locations for this study

See Locations Near You

Alaska Urological Institute dba Alaska Clinical Research Center ( Site 1083)
Anchorage Alaska, 99503, United States
Mayo Clinic in Arizona - Phoenix ( Site 1094)
Phoenix Arizona, 85054, United States More Info
Study Coordinator
Contact
480-342-6672
Arizona Urology Specialists (AUS)-Professional Park ( Site 1096)
Tucson Arizona, 85704, United States More Info
Study Coordinator
Contact
520-618-1010
UCLA Hematology/Oncology - Westwood (Building 200 Suite 140)-Department of Urology/Institute of Uro
Los Angeles California, 90095, United States
University of California Irvine Medical Center ( Site 1061)
Orange California, 92868, United States More Info
Study Coordinator
Contact
714-456-8148
Genesis Research LLC ( Site 1065)
Torrance California, 90505, United States More Info
Study Coordinator
Contact
310-602-5005
Colorado Clinical Research ( Site 1100)
Lakewood Colorado, 80228, United States More Info
Study Coordinator
Contact
303-996-9649
Urological Research Network ( Site 1106)
Hialeah Florida, 33016, United States More Info
Study Coordinator
Contact
786-431-2014
Sylvester Comprehensive Cancer Center ( Site 1056)
Miami Florida, 33136, United States More Info
Study Coordinator
Contact
305-243-2177
Woodlands Medical Specialists, PA ( Site 8002)
Pensacola Florida, 32503, United States
Emory School of Medicine ( Site 1076)
Atlanta Georgia, 30322, United States More Info
Study Coordinator
Contact
404-778-4823
Advanced Urology ( Site 1092)
Roswell Georgia, 30076, United States More Info
Study Coordinator
Contact
678-344-8900
Northwestern Memorial Hospital ( Site 1101)
Chicago Illinois, 60611, United States More Info
Study Coordinator
Contact
312-695-4484
Wichita Urology Group ( Site 1086)
Wichita Kansas, 67226, United States More Info
Study Coordinator
Contact
316-636-6141
Ochsner LSU Health Shreveport - Regional Urology ( Site 1099)
Shreveport Louisiana, 71106, United States More Info
Study Coordinator
Contact
318-683-0411
Henry Ford Health System ( Site 1062)
Detroit Michigan, 48202, United States More Info
Study Coordinator
Contact
313-916-8862
Michigan Institute of Urology ( Site 1077)
Troy Michigan, 48084, United States More Info
Study Coordinator
Contact
248-786-0467
Coastal Urology Associates ( Site 1055)
Brick New Jersey, 08724, United States
Morristown Medical Center ( Site 1090)
Morristown New Jersey, 07960, United States More Info
Study Coordinator
Contact
973-971-5373
Rutgers Cancer Institute of New Jersey ( Site 1059)
New Brunswick New Jersey, 08903, United States
St. Peter's Hospital Cancer Care Center ( Site 1087)
Albany New York, 12208, United States
Monter Cancer Center ( Site 1080)
Lake Success New York, 11042, United States More Info
Study Coordinator
Contact
516-734-8500
Veterans Affairs New York Harbor Healthcare System-PCF COE ( Site 1112)
New York New York, 10010, United States More Info
Study Coordinator
Contact
2126867500 ext.6383
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 1074)
New York New York, 10016, United States More Info
Study Coordinator
Contact
646-501-8206
Associated Medical Professionals of NY ( Site 1078)
Syracuse New York, 13210, United States
Tri-State Urologic Services PSC, Inc. ( Site 1091)
Cincinnati Ohio, 45212, United States More Info
Study Coordinator
Contact
513-841-7555
University Hospitals Cleveland Medical Center ( Site 1066)
Cleveland Ohio, 44106, United States
Ohio State University Arthur G James Cancer Hospital & Richard J Solove Research Institute ( Site 10
Columbus Ohio, 43210, United States More Info
Study Coordinator
Contact
614-366-7421
OHSU Knight Cancer Institute ( Site 1075)
Portland Oregon, 97210, United States
Oregon Urology Institute ( Site 1098)
Springfield Oregon, 97477, United States More Info
Study Coordinator
Contact
541-284-5508
MidLantic Urology ( Site 1071)
Bala-Cynwyd Pennsylvania, 19004, United States More Info
Study Coordinator
Contact
610-667-0458
Lancaster Urology ( Site 1079)
Lancaster Pennsylvania, 17604, United States More Info
Study Coordinator
Contact
717-431-2285
University of Pennsylvania ( Site 1088)
Philadelphia Pennsylvania, 19104, United States More Info
Study Coordinator
Contact
215-662-2891
Carolina Urologic Research Center ( Site 1085)
Myrtle Beach South Carolina, 29572, United States More Info
Study Coordinator
Contact
8434491010257
Urology Associates [Nashville, TN] ( Site 1072)
Nashville Tennessee, 37209, United States More Info
Study Coordinator
Contact
615-250-9268
Urology Clinics of North Texas, PLLC ( Site 1064)
Dallas Texas, 75231, United States More Info
Study Coordinator
Contact
214-580-1485
University Of Texas Southwestern Medical Center ( Site 1053)
Dallas Texas, 75390, United States More Info
Study Coordinator
Contact
214-645-8787
Texas Oncology-Fort Worth Cancer Center ( Site 8003)
Fort Worth Texas, 76104, United States
Houston Metro Urology ( Site 1111)
Houston Texas, 77027, United States More Info
Study Coordinator
Contact
832-549-4395
Texas Oncology-Plano West ( Site 8001)
Plano Texas, 75093, United States
Urology San Antonio Research ( Site 1108)
San Antonio Texas, 78229, United States More Info
Study Coordinator
Contact
832-472-5482
University of Vermont Medical Center ( Site 1057)
Burlington Vermont, 05401, United States More Info
Study Coordinator
Contact
802-656-9926
Urology of Virginia ( Site 1070)
Virginia Beach Virginia, 23462, United States More Info
Study Coordinator
Contact
757-452-3463
Nothern Cancer Institute ( Site 0003)
St Leonards New South Wales, 2065, Australia
Sydney Adventist Hospital ( Site 0001)
Wahroonga New South Wales, 2076, Australia
Ordensklinikum Linz GmbH Elisabethinen ( Site 0052)
Linz Oberosterreich, 4020, Austria More Info
Study Coordinator
Contact
+4373276777727
Univ. Klinik f. Urologie Innsbruck ( Site 0051)
Innsbruck Tirol, 6020, Austria
Medizinische Universität Wien ( Site 0054)
Vienna Wien, 1090, Austria More Info
Study Coordinator
Contact
+4367761942300
Universitaetsklinik Salzburg ( Site 0053)
Salzburg , 5020, Austria More Info
Study Coordinator
Contact
+435725527400
UZA University Hospital Antwerp ( Site 0105)
Edegem Antwerpen, 2650, Belgium More Info
Study Coordinator
Contact
+3238213718
CHU UCL Namur Site de Godinne ( Site 0103)
Yvoir Namur, 5530, Belgium More Info
Study Coordinator
Contact
+3281423858
O.L.V. Ziekenhuis Aalst ( Site 0106)
Aalst Oost-Vlaanderen, 9300, Belgium More Info
Study Coordinator
Contact
+3253724378
AZ Maria Middelares Gent ( Site 0102)
Gent Oost-Vlaanderen, 9000, Belgium More Info
Study Coordinator
Contact
+3292469522
UZ Gent ( Site 0101)
Gent Oost-Vlaanderen, 9000, Belgium More Info
Study Coordinator
Contact
+3293322811
Hospital São Carlos-Oncocentro Ce ( Site 1558)
Fortaleza Ceara, 60135, Brazil More Info
Study Coordinator
Contact
+5585981023963
Hospital Erasto Gaertner-CEPEP - Pesquisa Clínica ( Site 1551)
Curitiba Parana, 81520, Brazil More Info
Study Coordinator
Contact
+554133615195
Fundação Pio XII - Hospital de Câncer de Barretos-Unidade de Pesquisa Clínica ( Site 1553)
Barretos Sao Paulo, 14784, Brazil More Info
Study Coordinator
Contact
5517 3321.6637
Núcleo de Pesquisa Clínica da Rede São Camilo ( Site 1554)
São Paulo Sao Paulo, 04014, Brazil More Info
Study Coordinator
Contact
+551144500300
BP - A Beneficencia Portuguesa de São Paulo ( Site 1559)
Sao Paulo , 01321, Brazil More Info
Study Coordinator
Contact
5511981982259
Exdeo Clinical Research Inc. ( Site 0165)
Abbotsford British Columbia, V2T 1, Canada More Info
Study Coordinator
Contact
6048515667
Silverado Resarch Inc. ( Site 0155)
Victoria British Columbia, V8T 2, Canada
Horizon Health Network ( Site 0160)
Moncton New Brunswick, E1C 6, Canada More Info
Study Coordinator
Contact
5068574780
Princess Margaret Cancer Centre ( Site 0153)
Toronto Ontario, M5G 2, Canada More Info
Study Coordinator
Contact
4169462246
CIUSSS du Saguenay-Lac-St-Jean ( Site 0164)
Chicoutimi Quebec, G7H 5, Canada More Info
Study Coordinator
Contact
4185411000
CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0157)
Montreal Quebec, H1T 2, Canada More Info
Study Coordinator
Contact
5142523400x5766
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0
Quebec City Quebec, G1J 1, Canada More Info
Study Coordinator
Contact
418525444420414
CHUS - Hopital Fleurimont ( Site 0152)
Sherbrooke Quebec, J1H 5, Canada More Info
Study Coordinator
Contact
8193461110x12827
Fundación Hospital San Vicente de Paúl - Rionegro - Centros Especializados o de Centros Especializad
Rionegro Antioquia, 05404, Colombia More Info
Study Coordinator
Contact
3176594902
Oncomedica S.A.-Oncomedica S.A ( Site 1604)
Montería Cordoba, 23000, Colombia More Info
Study Coordinator
Contact
57-3226138826
Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 1605)
Bogota Distrito Capital De Bogota, 11132, Colombia More Info
Study Coordinator
Contact
573108965914
Administradora Country S.A. - Clinica del Country ( Site 1607)
Bogotá Distrito Capital De Bogota, 11022, Colombia More Info
Study Coordinator
Contact
573174365020
Oncologos del Occidente ( Site 1608)
Pereira Risaralda, 66000, Colombia More Info
Study Coordinator
Contact
573123887343
Hemato Oncologos SA-Oncology ( Site 1601)
Cali Valle Del Cauca, 76001, Colombia More Info
Study Coordinator
Contact
573212195102
CIMCA ( Site 1550)
San José San Jose, 10103, Costa Rica More Info
Study Coordinator
Contact
+50683893636
Policlinico San Bosco ( Site 0600)
San Jose , 10103, Costa Rica More Info
Study Coordinator
Contact
+50683384787
Tampere University Hospital [Tampere Finland] ( Site 0201)
Tampere Pirkanmaa, 33520, Finland More Info
Study Coordinator
Contact
+358331164621
Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand-Urology ( Site 1355)
Dijon Bourgogne, 21079, France More Info
Study Coordinator
Contact
33380293761
Hôpital Foch-Urology department ( Site 1351)
Suresnes Hauts-de-Seine, 92150, France More Info
Study Coordinator
Contact
+33146251961
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou ( Site 1353)
Rennes Ille-et-Vilaine, 35000, France More Info
Study Coordinator
Contact
33299284270
HENRI MONDOR HOSPITAL ( Site 1357)
Créteil Seine-et-Marne, 94000, France More Info
Study Coordinator
Contact
+33145178243
Klinikum Rechts der Isar. Technischen Universitaet Muenchen ( Site 0266)
Munich Bayern, 81675, Germany More Info
Study Coordinator
Contact
+498941402522
Klinikum Weiden ( Site 0259)
Weiden In Der Oberpfalz Bayern, 92637, Germany More Info
Study Coordinator
Contact
+49963033302
Universitaetsklinikum Wuerzburg ( Site 0265)
Wuerzburg Bayern, 97080, Germany More Info
Study Coordinator
Contact
+4993120132037
Krankenhaus der Barmherzigen Brüder Trier-Abteilung für Urologie und Kinderurologie ( Site 0262)
Trier Rheinland-Pfalz, 54292, Germany More Info
Study Coordinator
Contact
+496512082680
Universitaetsklinikum Jena ( Site 0252)
Jena Thuringen, 07747, Germany More Info
Study Coordinator
Contact
+49-3641-9-329901
General University Hospital of Patras ( Site 0302)
Patra Achaia, 265 0, Greece More Info
Study Coordinator
Contact
+302610999791
ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 0304)
Chaidari Attiki, 124 6, Greece More Info
Study Coordinator
Contact
+302105831255
Antikarkiniko Nosokomeio Thessalonikis THEAGENIO ( Site 0303)
Thessaloniki Kentriki Makedonia, 54007, Greece More Info
Study Coordinator
Contact
+302310898721
University Hospital of Larissa ( Site 0301)
Larissa Thessalia, 411 1, Greece More Info
Study Coordinator
Contact
+302413502811
Intervasc ( Site 1454)
Guatemala City , 01010, Guatemala More Info
Study Coordinator
Contact
+50259042511
INTEGRA Cancer Institute ( Site 1451)
Guatemala , 01010, Guatemala More Info
Study Coordinator
Contact
+50222790939
Grupo Medico Angeles-Grupo Medico Angeles ( Site 1453)
Guatemala , 01015, Guatemala More Info
Study Coordinator
Contact
+50240492110
Pécsi Tudományegyetem Klinikai Központ-Urológiai Klinika ( Site 1304)
Pécs Baranya, 7621, Hungary More Info
Study Coordinator
Contact
3672507323
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Urológiai Klinika ( Site 1303)
Szeged Csongrad, 6725, Hungary More Info
Study Coordinator
Contact
+36709411312
Semmelweis University-Urológiai Klinika ( Site 1301)
Budapest , 1082, Hungary More Info
Study Coordinator
Contact
+36208258762
Debreceni Egyetem Klinikai Kozpont ( Site 1302)
Debrecen , 4032, Hungary More Info
Study Coordinator
Contact
+36308544051
Ospedale Clinicizzato Santissima Annunziata ( Site 0361)
Chieti Abruzzo, 66100, Italy More Info
Study Coordinator
Contact
+390871357783
Ospedale San Raffaele ( Site 0362)
Milano Lombardia, 20132, Italy More Info
Study Coordinator
Contact
+39022643789
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0353)
Milan Milano, 20133, Italy More Info
Study Coordinator
Contact
+390223902402
Ospedale Mauriziano-SCDU ONCOLOGIA MEDICA ( Site 0366)
Torino Piemonte, 10128, Italy More Info
Study Coordinator
Contact
+39 0115082032
Azienda Ospedaliero Universitaria Careggi ( Site 0360)
Firenze Toscana, 50134, Italy More Info
Study Coordinator
Contact
+390557949920
Osp Generale Reg di Bolzano ( Site 0355)
Bolzano Trentino-Sudtirol, 39100, Italy More Info
Study Coordinator
Contact
+390471908953
Azienda USL 8 di Arezzo-Medical Oncology ( Site 0363)
Arezzo , 52100, Italy More Info
Study Coordinator
Contact
+390575255436
Istituto Tumori Giovanni Paolo II ( Site 0357)
Bari , 70124, Italy
Ospedale San Martino ( Site 0351)
Genova , 16132, Italy
Ospedale Buccheri La Ferla Fatebenefratelli ( Site 0352)
Palermo , 90123, Italy More Info
Study Coordinator
Contact
+39091479432
Policlinico Universitario A. Gemelli ( Site 0358)
Roma , 00168, Italy More Info
Study Coordinator
Contact
+390630154953
A.O.U. di Verona - Ospedale Civile Maggiore Borgo Trento ( Site 0356)
Verona , 37126, Italy More Info
Study Coordinator
Contact
+390458123876
Hirosaki University Hospital ( Site 0407)
Hirosaki Aomori, 036-8, Japan More Info
Study Coordinator
Contact
+81172335111
Ehime University Hospital ( Site 0414)
Toon Ehime, 791-0, Japan More Info
Study Coordinator
Contact
+81899645111
University of Tsukuba Hospital ( Site 0412)
Tsukuba Ibaraki, 305-8, Japan More Info
Study Coordinator
Contact
+81298533900
Kitasato University Hospital ( Site 0403)
Sagamihara Kanagawa, 252-0, Japan More Info
Study Coordinator
Contact
+81427788111
Yokosuka Kyosai Hospital ( Site 0406)
Yokosuka Kanagawa, 238-8, Japan More Info
Study Coordinator
Contact
+81468222710
Nara Medical University Hospital ( Site 0411)
Kashihara Nara, 634-8, Japan More Info
Study Coordinator
Contact
+81744223051
Chiba Cancer Center ( Site 0401)
Chiba , 260-8, Japan More Info
Study Coordinator
Contact
+81432645431
Harasanshin Hospital ( Site 0410)
Fukuoka , 812-0, Japan More Info
Study Coordinator
Contact
+81922913434
Osaka International Cancer Institute ( Site 0413)
Osaka , 541-8, Japan More Info
Study Coordinator
Contact
+81669451181
Osaka Metropolitan University Hospital ( Site 0404)
Osaka , 545-8, Japan More Info
Study Coordinator
Contact
+81666452121
Keio University Hospital ( Site 0405)
Tokyo , 160-8, Japan More Info
Study Coordinator
Contact
+81333531211
Tokyo Medical and Dental University Hospital ( Site 0409)
Tokyo , , Japan More Info
Study Coordinator
Contact
+81338136111
Asan Medical Center ( Site 0804)
Songpagu Seoul, 05505, Korea, Republic of
Korea University Anam Hospital ( Site 0801)
Seoul , 02841, Korea, Republic of More Info
Study Coordinator
Contact
+821099288097
Seoul National University Hospital ( Site 0802)
Seoul , 03080, Korea, Republic of More Info
Study Coordinator
Contact
+82220720361
Samsung Medical Center ( Site 0803)
Seoul , 06351, Korea, Republic of
University Malaya Medical Centre ( Site 1180)
Kuala Lumpur , 59100, Malaysia
Maastricht University Medical Centre ( Site 0453)
Maastricht Limburg, 6229 , Netherlands More Info
Study Coordinator
Contact
+31433876543
Erasmus MC ( Site 0451)
Rotterdam Zuid-Holland, 3015G, Netherlands More Info
Study Coordinator
Contact
+31107040704
Universitair Medisch Centrum Utrecht-Medical Oncology ( Site 0455)
Utrecht , 3584 , Netherlands More Info
Study Coordinator
Contact
31887556308
Akershus University Hospital ( Site 0553)
Lorenskog Akershus, 1478, Norway More Info
Study Coordinator
Contact
+4767960000
Stavanger universitetssykehus ( Site 0555)
Stavanger Rogaland, 4011, Norway More Info
Study Coordinator
Contact
+4751518000
Hospital Nacional Guillermo Almenara Irigoyen ( Site 0601)
La Victoria Lima, 15033, Peru
Oncosalud ( Site 0603)
Lima Muni Metro De Lima, 15036, Peru More Info
Study Coordinator
Contact
+51992756559
Hospital Militar Central [Lima, Peru] ( Site 0604)
Lima , 15076, Peru More Info
Study Coordinator
Contact
+51997468543
Uniwesytecki Szpital Kliniczny we Wroclawiu ( Site 0669)
Wroclaw Dolnoslaskie, 50-55, Poland More Info
Study Coordinator
Contact
+48601143281
Nasz Lekarz Przychodnie Medyczne ( Site 0679)
Torun Kujawsko-pomorskie, 87-10, Poland More Info
Study Coordinator
Contact
+48563004380
Pratia MCM Krakow ( Site 0668)
Krakow Malopolskie, 30-51, Poland
Szpital Wojewódzki im. Świętego Lukasza SP ZOZ w Tarnowie ( Site 0681)
Tarnow Malopolskie, 33-10, Poland More Info
Study Coordinator
Contact
+48728355694
Urologica Praktyka Lekarska Adam Marcheluk ( Site 0654)
Siedlce Mazowieckie, 08-11, Poland More Info
Study Coordinator
Contact
+48504283093
Medical Concierge Centrum Medyczne ( Site 0676)
Warsaw Mazowieckie, 02-79, Poland More Info
Study Coordinator
Contact
+48224166500
Luxmed Onkologia sp. z o. o. ( Site 0653)
Warszawa Mazowieckie, 01-74, Poland
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 0678)
Przemysl Podkarpackie, 37-70, Poland More Info
Study Coordinator
Contact
+48661957237
Szpital Specjalistyczny w Koscierzynie Sp. z o.o. ( Site 0671)
Koscierzyna Pomorskie, 83-40, Poland
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Slupsku ( Site 0655)
Slupsk Pomorskie, 76-20, Poland More Info
Study Coordinator
Contact
+48598460340
LIFTMED ( Site 0652)
Rybnik Slaskie, 44-20, Poland
Clinical Research Center Sp. z o.o. ( Site 0674)
Poznan Wielkopolskie, 61-73, Poland More Info
Study Coordinator
Contact
+48616632513
2CA Braga. Centro Clinico Academico ( Site 0705)
Braga , 4710-, Portugal More Info
Study Coordinator
Contact
+351253027249
Inst. Portugues de Oncologia de Coimbra Francisco Gentil EPE ( Site 0704)
Coimbra , 3000-, Portugal
Inst. Portugues de Oncologia de Lisboa Francisco Gentil EPE ( Site 0708)
Lisboa , 1099-, Portugal More Info
Study Coordinator
Contact
+351217229892
CHLN Hospital Santa Maria ( Site 0702)
Lisboa , 1649-, Portugal More Info
Study Coordinator
Contact
+351217805056
Hospital CUF Descobertas ( Site 0706)
Lisboa , 1998-, Portugal
Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 0701)
Porto , 4200-, Portugal More Info
Study Coordinator
Contact
+351225084000
Advance Urology and Laparoscopic Center ( Site 0757)
Ponce , 00716, Puerto Rico More Info
Study Coordinator
Contact
7874329059
Ad-Vance Medical Research ( Site 0756)
Ponce , 00717, Puerto Rico More Info
Study Coordinator
Contact
7878406448
Hospital Universitario Lucus Augusti ( Site 0852)
Lugo La Coruna, 27003, Spain More Info
Study Coordinator
Contact
+34982296459
Hospital Universitario Quiron Madrid ( Site 0862)
Pozuelo de Alarcon Madrid, Comunidad De, 28223, Spain More Info
Study Coordinator
Contact
+34914521987
Clinica Universitaria de Navarra ( Site 0863)
Pamplona Navarra, 31008, Spain
Fundacio Puigvert ( Site 0864)
Barcelona , 08025, Spain More Info
Study Coordinator
Contact
+34934169700
Hospital Universitario Gregorio Maranon ( Site 0854)
Madrid , 28007, Spain More Info
Study Coordinator
Contact
+34914269070
Clinica Universitaria Navarra - Madrid ( Site 0860)
Madrid , 28027, Spain
MD Anderson Cancer Center Madrid ( Site 0859)
Madrid , 28033, Spain More Info
Study Coordinator
Contact
+34917878600
Hospital Universitario Ramon y Cajal ( Site 0857)
Madrid , 28034, Spain More Info
Study Coordinator
Contact
+34913368263
Hospital Universitario La Paz ( Site 0866)
Madrid , 28046, Spain More Info
Study Coordinator
Contact
+34 912 071 876
Hospital La Fe de Valencia ( Site 0855)
Valencia , 46026, Spain More Info
Study Coordinator
Contact
+34961244188
Universitaetsspital Basel ( Site 1201)
Basel Basel-Stadt, 4031, Switzerland More Info
Study Coordinator
Contact
+41615565477
Hopitaux Universitaires de Geneve HUG ( Site 1204)
Geneve , 1205, Switzerland More Info
Study Coordinator
Contact
+41223727876
Universitaetsspital Zurich ( Site 1203)
Zurich , 8091, Switzerland More Info
Study Coordinator
Contact
+41442555440
China Medical University Hospital-Department of Urology ( Site 1654)
Taichung , 40447, Taiwan More Info
Study Coordinator
Contact
+886422052121 ext.4440
Taichung Veterans General Hospital ( Site 1653)
Taichung , 407, Taiwan More Info
Study Coordinator
Contact
886-4-2359-2525 ext.5124
Taipei Veterans General Hospital ( Site 1652)
Taipei , 11217, Taiwan More Info
Study Coordinator
Contact
886-2-28757519#306
Memorial Sisli Hastanesi-Medical Oncology ( Site 0965)
Stanbul Istanbul, 34385, Turkey More Info
Study Coordinator
Contact
+905325755400
Eskisehir Osmangazi Universitesi Hastanesi ( Site 0953)
Eskisehir , 26480, Turkey More Info
Study Coordinator
Contact
+905327149696
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 0963)
Istanbul , 34722, Turkey More Info
Study Coordinator
Contact
+905323430723
Dokuz Eylul Universitesi ( Site 0959)
Izmir , 35340, Turkey
Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi ( Site 0961)
Konya , 42000, Turkey More Info
Study Coordinator
Contact
+905322679838
Raigmore Hospital ( Site 1006)
Inverness Highland, IV2 3, United Kingdom More Info
Study Coordinator
Contact
+4401463706356
St Bartholomew s Hospital ( Site 1008)
London London, City Of, EC1A , United Kingdom More Info
Study Coordinator
Contact
+442078828505
St Georges University Hospitals NHS Foundation Trust. ( Site 1005)
London London, City Of, SW17 , United Kingdom More Info
Study Coordinator
Contact
+442087253362

How clear is this clinincal trial information?

Study is for people with:

Bladder Cancer

Phase:

Phase 3

Estimated Enrollment:

1405

Study ID:

NCT03711032

Recruitment Status:

Recruiting

Sponsor:


Merck Sharp & Dohme LLC

How clear is this clinincal trial information?

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