Bladder Cancer Clinical Trial

Prophylactic Antibiotics in Cystectomy With Diversion

Summary

Using a randomized 2 arm design, this study is being conducted to test for non-inferiority of no prophylactic antibiotic therapy versus the prophylactic oral antibiotic, nitrofurantoin, through comparison of rates of postoperative urinary tract infections within the 90-day postoperative period in patients with muscle invasive bladder cancer who undergo radical cystectomy with urinary diversion.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Presence of muscle invasive bladder cancer and planning to undergo radical cystectomy with either ileal conduit or neobladder diversion.
18 years of age or older

Exclusion Criteria:

Currently receiving antimicrobials for active infection
Poor renal function with GFR < 30 ml/min
Allergy to nitrofurantoin and unable to take an alternative antibiotic (cephalexin, trimethoprim-sulfamethoxazole, or ciprofloxacin)
Pregnancy
Unable to provide Informed consent

Study is for people with:

Bladder Cancer

Phase:

Early Phase 1

Estimated Enrollment:

120

Study ID:

NCT06190197

Recruitment Status:

Not yet recruiting

Sponsor:

University of Minnesota

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There is 1 Location for this study

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University of Minnesota
Minneapolis Minnesota, 55414, United States More Info
Maressa Twedt
Contact
612-626-6661
[email protected]

How clear is this clinincal trial information?

Study is for people with:

Bladder Cancer

Phase:

Early Phase 1

Estimated Enrollment:

120

Study ID:

NCT06190197

Recruitment Status:

Not yet recruiting

Sponsor:


University of Minnesota

How clear is this clinincal trial information?

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