Breast Cancer Clinical Trial
A Multi-Modality Surveillance Program for Women at High Risk for Breast Cancer
This study is aimed to establish a registry of women undergoing intensive surveillance for the early detection of breast cancer in high-risk women.
- Known BRCA1 or BRCA2, TP53, PALB2, PTEN and CDH1 carrier. Women with pathogenic mutations in any other cancer susceptibility genes are eligible only if they also have a high Polygenic Risk Score.
OR With life time risk of 30% or higher, based on Polygenic Risk Score that integrates genetic and non-genetic factors.
Without prior breast cancer.
Must be older than 25 years.
Willing to travel to University of Chicago Medical Center for imaging studies as well as any necessary follow-up procedures.
Be able to give informed consent.
Active cancer at the time of enrollment.
Current pregnancy or plans for pregnancy within two years of enrollment.
Presence of a pacemaker or any other metallic foreign objects in their body that interferes with an MRI.
Breast surgery within two weeks of study entry.
History of kidney disease or abnormal kidney function.
Women can be taking hormone replacement therapy, tamoxifen, raloxifene, aromatase inhibitors or participating in a chemoprevention trial.
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