Breast Cancer Clinical Trial

A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy

Summary

This is a Phase III, two-arm, randomized, double-blind placebo-controlled study in participants with HER2-positive primary breast cancer who have received preoperative chemotherapy and HER2-directed therapy, including trastuzumab followed by surgery, with a finding of residual invasive disease in the breast and/or axillary lymph nodes.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Histologically confirmed invasive breast carcinoma
Centrally-confirmed human epidermal growth factor receptor 2 (HER2)-positive invasive breast cancer
Centrally confirmed PD-L1 and hormone receptor status
Clinical stage at disease presentation: cT4/anyN/M0, any cT/N2-3/M0, or cT1-3/N0-1/M0 (participants with cT1mi/T1a/T1b/N0 are not eligible)
Completion of pre-operative systemic chemotherapy including at least 9 weeks of taxane and 9 weeks of trastuzumab (anthracycline and/or additional HER2-targeted agents are permitted)
<=12 weeks between primary surgery and randomization
Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1
Screening left ventricular ejection fraction (LVEF) >= 50% and no decrease in LVEF by >15% from the pre-chemotherapy LVEF. If no pre-chemotherapy LVEF, screening LVEF >= 55%
Life expectancy >= 6 months
Adequate hematologic and end organ function

Exclusion Criteria:

Stage IV breast cancer
An overall response of disease progression according to the investigator at the conclusion of preoperative systemic therapy
Prior treatment with T-DM1, or atezolizumab, or other immune checkpoint inhibitors
History of exposure to various cumulative doses of anthracyclines
History of other malignancy within 5 years prior to screening, except for appropriately treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, Stage I uterine cancer, or ductal carcinoma in situ (DCIS)
Current grade >=2 peripheral neuropathy
History of idiopathic pulmonary fibrosis, organizing pneumonia, or pneumonitis
History of or active autoimmune disease or immune deficiency
Treatment with immunostimulatory or immunosuppressive agents
Cardiopulmonary dysfunction
Any known active liver disease

Study is for people with:

Breast Cancer

Phase:

Phase 3

Estimated Enrollment:

1700

Study ID:

NCT04873362

Recruitment Status:

Recruiting

Sponsor:

Hoffmann-La Roche

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There are 295 Locations for this study

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Alabama Oncology
Alabaster Alabama, 35007, United States
Roy and Patricia Disney Family Cancer Center- Providence Saint Joseph Medical Center
Burbank California, 91505, United States
California Cancer Associate for Research & Excellence
Fresno California, 93720, United States
Glendale Adventist Medical Ctr
Glendale California, 91206, United States
UCLA Medical Center
Santa Monica California, 90404, United States
Innovation Clinical Research Institute
Whittier California, 90603, United States
Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy)
Jacksonville Florida, 32256, United States
Florida Cancer Specialists
West Palm Beach Florida, 33401, United States
University Cancer & Blood Center, LLC; Research
Athens Georgia, 30607, United States
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
Carrollton Georgia, 30117, United States
Elmhurst Memorial Healthcare
Elmhurst Illinois, 60126, United States
Edward Cancer Center Naperville
Naperville Illinois, 60540, United States
Edward Cancer Center Plainfield
Plainfield Illinois, 60585, United States
University of Iowa
Iowa City Iowa, 52242, United States
Pontchartrain Cancer Center
Covington Louisiana, 70433, United States
New England Cancer Specialists
Scarborough Maine, 04074, United States
University of Maryland Medical Center
Baltimore Maryland, 21201, United States
Mercy Medical Center
Baltimore Maryland, 21202, United States
Henry Ford Health System; Clinical Trials Office; Clinical Trials Office
Detroit Michigan, 48202, United States
Jackson Oncology Associates, PLLC
Jackson Mississippi, 39202, United States
Central Care Cancer Center; NC
Bolivar Missouri, 65613, United States
Cooper Cancer Institute
Camden New Jersey, 08103, United States
MD Anderson Cancer Center at Cooper
Camden New Jersey, 08103, United States
Jersey Shore University Medical Centre
Neptune New Jersey, 07753, United States
The Valley Hospital
Paramus New Jersey, 07652, United States
Mount Sinai Medical Center
New York New York, 10029, United States
Great Lakes Cancer Center
Williamsville New York, 14221, United States
Messino Cancer Centers
Asheville North Carolina, 28806, United States
Providence Health & Services - Oregon
Portland Oregon, 97213, United States
Abramson Cancer Center; Univ of Pennsylvania; Clinical Research Unit
Philadelphia Pennsylvania, 19106, United States
Lankenau Hospital
Wynnewood Pennsylvania, 19096, United States
Charleston Oncology, P .A
Charleston South Carolina, 29414, United States
Avera Cancer Institute
Sioux Falls South Dakota, 57105, United States
SCRI Tennessee Oncology Chattanooga
Chattanooga Tennessee, 37404, United States
The West Clinic; West Cancer Center
Germantown Tennessee, 38138, United States
Thompson Cancer Survival Center
Knoxville Tennessee, 37916, United States
Tennessee Oncology; Sarah Cannon Research Institute
Nashville Tennessee, 37203, United States
Joe Arrington Cancer Research & Treatment Center
Lubbock Texas, 79410, United States
Mays Cancer Center at UT Health San Antonio MD Anderson Cancer
San Antonio Texas, 78229, United States
Hematology Oncology Associates of Fredericksburg, Inc.
Fredericksburg Virginia, 22408, United States
Virginia Oncology Associates - New Port News
Newport News Virginia, 23606, United States
Virginia Oncology Associates
Norfolk Virginia, 23502, United States
Virginia Cancer Institute
Richmond Virginia, 23229, United States
Virginia Oncology Associates - Virginia Beach
Virginia Beach Virginia, 23456, United States
Providence Regional Cancer Partnership
Everett Washington, 98201, United States
Kadlec Regional Medical Center
Kennewick Washington, 99336, United States
Northwest Medical Specialties
Tacoma Washington, 98405, United States
Macarthur Cancer Therapy Centre
Campbelltown New South Wales, 2560, Australia
Kinghorn Cancer Centre; St Vincents Hospital
Darlinghurst New South Wales, 2010, Australia
Royal North Shore Hospital; Department of Medical Oncology
St Leonards New South Wales, 2065, Australia
Princess Alexandra Hospital; Cancer Trials Unit
Woolloongabba Queensland, 4102, Australia
Peter MacCallum Cancer Centre; Medical Oncology
Melbourne Victoria, 3000, Australia
Tiroler Landeskrankenanstalten Ges.M.B.H.; Abt. Für Gynäkologie
Innsbruck , 6020, Austria
Ordensklinikum Linz Barmherzige Schwestern; Interne 1 - Hämato-Onkologie
Linz , 4010, Austria
Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt.
Salzburg , 5020, Austria
AKH - Medizinische Universität Wien; Department of Oncology
Vienna , 1090, Austria
Cliniques Universitaires St-Luc
Bruxelles , 1200, Belgium
Jessa Zkh (Campus Virga Jesse)
Hasselt , 3500, Belgium
Clinique St. Elizabeth
Namur , 5000, Belgium
Hospital Sao Rafael - HSR
Salvador BA, 41253, Brazil
Crio - Centro Regional Integrado de Oncologia
Fortaleza CE, 60336, Brazil
Hospital Araujo Jorge; Departamento de Ginecologia E Mama
Goiania GO, 74605, Brazil
Hospital Nossa Senhora da Conceicao
Porto Alegre RS, 91350, Brazil
Hospital de Base de Sao Jose do Rio Preto
Sao Jose do Rio Preto SP, 15090, Brazil
Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda
Sao Paulo SP, 01317, Brazil
Núcleo de Pesquisa São Camilo; ONCOLOGIA CLINICA / QUIMIOTERAPIA
Sao Paulo SP, 04014, Brazil
COC Plovdiv; First Medical Oncology Department
Plovdiv , 4004, Bulgaria
Medical Center "Nadezhda Clinical" EOOD; Medical Oncology Department
Sofia , 1330, Bulgaria
University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD
Sofia , 1527, Bulgaria
Sichuan Cancer Hospital
Chengdu City , 61004, China
West China Hospital - Sichuan University
Chengdu City , 61004, China
Chongqing Cancer Hospital
Chongqing , 40003, China
The First Affilicated Hospital, Sun Yat-sen University
Guangzhou City , 51008, China
Guangdong Provincial People's Hospital; Breast
Guangzhou City , 51018, China
Sun Yat-sen Memorial Hospital
Guangzhou , 51000, China
Harbin Medical University Cancer Hospital
Harbin , 15008, China
Zhongshan Hospital Fudan University
Shanghai , 20003, China
Tianjin Medical University Cancer Institute & Hospital
Tianjing , 30006, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan City , 43002, China
First Affiliated Hospital of Medical College of Xi'an Jiaotong University
Xi'an , 71006, China
Zhejiang Cancer Hospital
Zhejiang , 31002, China
Henan Cancer Hospital
Zhengzhou , 45000, China
Masarykův onkologický ústav; Klinika komplexní onkologické péče
Brno , 656 5, Czechia
Fakultni Nemocnice Hradec Kralove; Dept of Radiotherapy & Oncology
Hradec Kralove , 500 0, Czechia
Nemocnice AGEL Novy Jicin a.s.; Oddeleni radioterapie a onkologie
Novy Jicin , 741 0, Czechia
Fakultni nemocnice Olomouc; Onkologicka klinika
Olomouc , 779 0, Czechia
Fakultni Poliklinika Vseobecne Fakultni Niemocnice; Onkologicka Klinika
Praha 2 , 128 0, Czechia
Thomayerova nemocnice; Onkologicka klinika 1. LF UK A TN
Praha 4 - Krc , 140 5, Czechia
Fakultni nemocnice v Motole; Onkologicka klinika 2. LF UK a FN Motol
Praha 5 , 150 0, Czechia
Herlev Hospital; Afdeling for Kræftbehandling
Herlev , 2730, Denmark
Vejle Sygehus; Onkologisk Afdeling
Vejle , 7100, Denmark
Institut Sainte Catherine
Avignon , 84082, France
CHRU Besançon
Besançon , 25030, France
Polyclinique Bordeaux Nord Aquitaine
Bordeaux , 33300, France
Hopital Morvan
Brest , 29200, France
Centre Francois Baclesse; Comite Sein
Caen , 14076, France
Groupe Hospitalier Public Du Sud De L'Oise GHPSO; Oncologie
Creil Cedex 1 , 60109, France
CLCC Leon Berard Lyon
Lyon , 69008, France
Centre Hospitalier Uni Ire Caremeau; Radiotherapie & Oncologie
Nimes , 30029, France
Groupe Hospitalier Diaconesses
Paris , 75020, France
Institut Curie; Oncologie Medicale
Paris , 75231, France
Pole Regional De Cancerologie
Poitiers , 86021, France
HOPITAL RENE HUGUENIN, Institut Curie; Service d'Oncologie Médicale.
Saint-Cloud , 92210, France
Klinikum Augsburg; Frauenklinik
Augsburg , 86156, Germany
Gemeinschaftspraxis für Hämatologie und Onkologie Dr. Reichert/Dr.Janssen
Aurich , 26603, Germany
Hochtaunus-Kliniken gGmbH; Krankenhaus Bad Homburg; Frauenklinik
Bad Homburg vdH , 61352, Germany
Hochwaldkrankenhaus; Abt.Gynäkologie Geburtshilfe u.Senologie
Bad Nauheim , 61231, Germany
Onkologische Schwerpunktpraxis Kurfürstendamm
Berlin , 10707, Germany
Vivantes Klinikum Am Urban; Zentrum für Brusterkrankungen
Berlin , 10967, Germany
Gynäkologisches Zentrum Bonn
Bonn , 53111, Germany
Marienhospital Bottrop
Bottrop , 46236, Germany
Städtisches Klinikum Dessau
Dessau-Roßlau , 06847, Germany
Gynonco Düsseldorf, MVZ Medical Center GmbH
Düsseldorf , 40235, Germany
Frauenarztpraxis Dr. Apel, Dr. Kolpin
Erfurt , 99084, Germany
Universitätsklinikum Erlangen; Frauenklinik
Erlangen , 91054, Germany
Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH; Klinik für Senologie / Brustzentrum
Essen , 45136, Germany
AGAPLESION Markus-Krankenhaus
Frankfurt , 60431, Germany
Klinik Johann Wolfgang von Goethe Uni; Klinik für Frauenheilkunde und Geburtshilfe
Frankfurt , 60596, Germany
Praxis für Interdisziplinäre Onkologie und Hämatologie GbR
Freiburg , 79110, Germany
St. Barbara-Klinik Hamm-Heessen GmbH; Frauenklinik
Hamm , 59073, Germany
Diakovere Henriettenstift, Frauenklinik
Hannover , 30559, Germany
Städtisches Klinikum Karlsruhe gGmbH; Frauenklinik
Karlsruhe , 76133, Germany
UNI-Klinikum Campus Kiel Klinik für Gynäkologie und Geburtshilfe
Kiel , 24105, Germany
Universitätsklinikum Leipzig; Klinik und Poliklinik für Frauenheilkunde
Leipzig , 04103, Germany
Städtische Klinik Lüneburg; Frauenklinik
Lüneburg , 21339, Germany
Klinik & Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt
München , 80336, Germany
Sana Klinikum Offenbach GmbH; Klinik für Gynäkologie & Geburtshilfe
Offenbach , 63069, Germany
Klinikum Ernst von Bergmann; Frauenklinik
Potsdam , 14467, Germany
Klinikum am Steinenberg Frauenklinik
Reutlingen , 72764, Germany
Leopoldina Krankenhaus der Stadt Schweinfurt GmbH
Schweinfurt , 97422, Germany
Johanniter-Krankenhaus Genthin-Stendal; Klinik Für Frauenheilkunde & Geburtshilfe
Stendal , 39576, Germany
Metropolitan General Hospital
Cholargos , 155 6, Greece
University General Hospital of Heraklion
Crete , 711 1, Greece
University Hospital of Larissa;Department of Medical Oncology
Larissa , 411 1, Greece
Metropolitan Hospital; 2Nd Oncology Clinic
Piraeus , 185 4, Greece
Euromedical General Clinic of Thessaloniki; Oncology Department
Thessaloniki , 546 4, Greece
Queen Mary Hospital; Surgery
Hong Kong , 852, Hong Kong
Pamela Youde Nethersole Eastern Hospital; Clinical Oncology
Hong Kong , , Hong Kong
Tuen Mun Hospital; Clinical Oncology
Hong Kong , , Hong Kong
Szent Margit Hospital
Budapest , 1032, Hungary
Honvédelmi Minisztérium Állami Egészségügyi Központ; Onkológiai Osztály; Oncology department
Budapest , 1062, Hungary
Orszagos Onkologiai Intezet; B Belgyogyaszati Osztaly
Budapest , 1122, Hungary
Debreceni Egyetem Klinikai Kozpont ; Department of Oncology
Debrecen , 4032, Hungary
Borsod-Abauj-Zemplen Megyei Korhaz Es Egyetemi Oktato Korhaz; Onkologiai Osztaly
Miskolc , 3501, Hungary
Rajiv Gandhi Cancer Institute & Research Center
New Delhi Delhi, 11008, India
Max Super Speciality Hospital; Medical Oncology
North WEST Delhi Delhi, 11008, India
Hemato Oncology Clinic Ahmedabad Pvt Ltd
Ahmadabad Gujarat, 38005, India
Manipal Hospital; Department of Oncology
Bangalore Karnataka, 56001, India
Tata Memorial Hospital; Dept of Medical Oncology
Mumbai Maharashtra, 40001, India
HCG Manavata Cancer Centre
Nashik Maharashtra, 42200, India
Sahyadri Super Specialty Hospital Hadapsar
Pune Maharashtra, 41102, India
Christian Med Clg & Hspt
Wallajah Tamil NADU, 63251, India
TATA Medical Centre; Medical Oncology
Kolkata WEST Bengal, 70015, India
AORN'S.G.Moscati; Oncologia
Avellino Campania, 83100, Italy
U.O.C. Oncologia Medica Senologica
Napoli Campania, 80131, Italy
Università degli Studi Federico II; Clinica di Oncologia Medica
Napoli Campania, 80131, Italy
Policlinico S.Orsola-Malpighi; Istituto Oncologia R. Addarii
Bologna Emilia-Romagna, 40138, Italy
A.O. Universitaria Policlinico Di Modena; Oncologia
Modena Emilia-Romagna, 41100, Italy
Irccs Centro Di Riferimento Oncologico (CRO)
Aviano Friuli-Venezia Giulia, 33081, Italy
ASU FC S. M. DELLA MISERICORDIA; Oncologia
Udine Friuli-Venezia Giulia, 33100, Italy
Policlinico Universitario Agostino Gemelli
Roma Lazio, 00168, Italy
ASST DEGLI SPEDALI CIVILI DI BRESCIA; Oncologia Medica
Brescia Lombardia, 25123, Italy
Ospedale San Raffaele; Medical Oncology
Milano Lombardia, 20132, Italy
Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 1
Milano Lombardia, 20133, Italy
Ospedale Civile - Livorno
Livorno Toscana, 57124, Italy
Azlenda Ospendaliero-Universitaria Pisana; C.O. Oncologia 2
Pisa Toscana, 56100, Italy
University of Eastern Piedmont - Maggiore della Carità University Hospital
Novara Umbria, 28100, Italy
IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Seconda
Padova Veneto, 35128, Italy
International Cancer Institute (ICI)
Eldoret , 30100, Kenya
Aga Khan University Hospital
Nairobi , 30270, Kenya
Kyungpook National University Medical Center
Daegu , 41404, Korea, Republic of
National Cancer Center
Goyang-si , 10408, Korea, Republic of
Seoul National University Bundang Hospital
Seongnam-si , 13605, Korea, Republic of
Korea University Anam Hospital
Seoul , 02841, Korea, Republic of
Seoul National University Hospital
Seoul , 03080, Korea, Republic of
Severance Hospital, Yonsei University Health System
Seoul , 03722, Korea, Republic of
Asan Medical Center
Seoul , 05505, Korea, Republic of
Gangnam Severance Hospital
Seoul , 06273, Korea, Republic of
Samsung Medical Center
Seoul , 06351, Korea, Republic of
Seoul St Mary's Hospital
Seoul , 06591, Korea, Republic of
Korea University Guro Hospital
Seoul , 08308, Korea, Republic of
Investigacion Oncofarmaceutica
La Paz BAJA California SUR, 23040, Mexico
Health Pharma Professional Research
Cdmx Mexico CITY (federal District), 03100, Mexico
Centro Medico Dalinde
Cdmx Mexico CITY (federal District), 06760, Mexico
Christus Muguerza Clinica Vidriera
Monterrey Nuevo LEON, 64570, Mexico
Centro de Investigacion Clinica de Oaxaca
Oaxaca de Juárez Oaxaca, 68020, Mexico
Instituto Nacional De Cancerologia; Oncology; Tumores Mamarios
Distrito Federal , 14000, Mexico
Auckland City Hospital, Cancer and Blood Research
Auckland , 1023, New Zealand
Tauranga Hospital, Clinical Trials Unit; BOP Clinical School
Tauranga , 3112, New Zealand
Bialostockie Centrum Onkologii; Oddzial Onkologii Klinicznej
Bialystok , 15-02, Poland
Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i Radioterapii
Gdańsk , 80-21, Poland
Narodowy Instytut Onkologii Odział w Gliwicach; Centrum Diagnostyki i Leczenia Chorób Piersi
Gliwice , 44-10, Poland
Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kliniki Onkologii
Kraków , 30-68, Poland
Wielkopolskie Centrum Onkologii; Oddzial Chemioterapii
Poznan , 61-86, Poland
Centrum Onkologii Instytut im.M. Sklodowskiej-Curie; Klin. Nowot. Piersii i Chirurgii Rekonstruk
Warszawa , 02-78, Poland
Hospital CUF Tejo; Oncologia Médica e Hematologia
Lisboa , 1350-, Portugal
Hospital de Santa Maria; Servico de Oncologia Medica
Lisboa , 1649-, Portugal
Hospital Beatriz Angelo; Departamento de Oncologia
Loures , 2674-, Portugal
Centro Hospitalar do Porto - Hospital de Santo António; Oncologia
Porto , 4099-, Portugal
IPO do Porto; Servico de Oncologia Medica
Porto , 4200-, Portugal
Filantropia Clinical Hospital; Medical oncology
Bucuresti , 02116, Romania
Prof.dr. Alexandru Trestioreanu, The Oncology Institute; Medical oncology I
Bucuresti , 02232, Romania
Amethyst Cluj; Medical Oncology
Cluj County , 40728, Romania
Cluj-Napoca Emergency Clinical County Hospital; Medical Oncology
Cluj-Napoca , 40000, Romania
Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca; Radioterapie I - Oncologie
Cluj-Napoca , 40001, Romania
Sf. Nectarie Oncology Center; Medical oncology
Craiova , 20034, Romania
Oncomed SRL
Timisoara , 30023, Romania
Republican Clinical Oncological Dispensary of the Ministry of Healthcare; Chemotherapy department
Kazan Karelija, 42002, Russian Federation
FSBI"National Medical Research Center of Oncology named after N.N.Petrov" MHRF
St Petersburg Leningrad, 19775, Russian Federation
MEDSI Clinical Hospital on Pyatnitsky Highway; Department of antitumor drug therapy
Moscow Moskovskaja Oblast, 14342, Russian Federation
SBIH "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of DHM"
Moskva Moskovskaja Oblast, 11112, Russian Federation
Nizhny Novgorod Regional Clinical Oncology Center
Nizhny Novgorod Niznij Novgorod, 60312, Russian Federation
Medical Clinic "AB Medical group"
Sankt-peterburg Sankt Petersburg, 19600, Russian Federation
SBIH Kaluga Region Clinical Oncology Dispensary
Kaluga , 24800, Russian Federation
Krasnoyarsk Regional Oncology Dispensary n.a. Krizhanovsky; Chemotherapy
Krasnoyarsk , 66013, Russian Federation
Oncology Dispensary#1; Out-Patient Oncology Dept
Moscow , 10500, Russian Federation
FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF
Moscow , 11547, Russian Federation
LLC Medical and Sanitary Unit "Clinician"
Novosibirsk , 63009, Russian Federation
S-Pb clinical scientific practical center of specialized kinds of medical care (oncological)
Saint-Petersburg , 19775, Russian Federation
SBI of Healthcare Samara Regional Clinical Oncology Dispensary
Samara , 44303, Russian Federation
SBI of Healthcare Leningrad Regional Oncology Dispensary
St Petersburg , 19110, Russian Federation
Regional Oncology Dispensary
Tomsk , 63406, Russian Federation
Regional Clinical Oncology Hospital
Yaroslavl , 15004, Russian Federation
National Cancer Centre; Medical Oncology
Singapore , 16961, Singapore
Hospital General Universitario de Elche; Servicio de Oncologia
Elche Alicante, 03203, Spain
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia
Badalona Barcelona, 08916, Spain
Corporacio Sanitaria Parc Tauli; Servicio de Oncologia
Sabadell Barcelona, 8208, Spain
Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Oncologia
A Coruña LA Coruña, 15006, Spain
Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia
Santiago de Compostela LA Coruña, 15706, Spain
Hospital Quiron de Madrid; Servicio de Oncologia
Pozuelo de Alarcon Madrid, 28223, Spain
Hospital Alvaro Cunqueiro; Servicio de Oncologia
Vigo Pontevedra, 36213, Spain
Hospital Universitario de Canarias;servicio de Oncologia
La Laguna Tenerife, 38320, Spain
Hospital de Basurto; Servicio de Oncologia
Bilbao Vizcaya, 48013, Spain
Hospital del Mar; Servicio de Oncologia
Barcelona , 08003, Spain
Vall d´Hebron Institute of Oncology (VHIO), Barcelona
Barcelona , 08035, Spain
Hospital Clinic Barcelona; Servicio de oncologia
Barcelona , 08036, Spain
Hospital Universitario Clínico San Cecilio; Servicio de oncologia
Granada , 18016, Spain
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia
Jaen , 23007, Spain
Hospital General Universitario Gregorio Marañon; Servicio de Oncologia
Madrid , 28007, Spain
Hospital Ramon y Cajal; Servicio de Oncologia
Madrid , 28034, Spain
Hospital Clinico San Carlos; Servicio de Oncologia
Madrid , 28040, Spain
Hospital Universitario La Paz; Servicio de Oncologia
Madrid , 28046, Spain
Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia
Malaga , 29010, Spain
Hospital Clinico Universitario de Salamanca; Servicio de Oncologia
Salamanca , 37007, Spain
Hospital Universitario Virgen Macarena; Servicio de Oncologia
Sevilla , 41009, Spain
Hospital Universitario Virgen del Rocio; Servicio de Oncologia
Sevilla , 41013, Spain
Hospital Clínico Universitario de Valencia; Servicio de Oncología
Valencia , 46010, Spain
Hospital Universitario Dr. Peset; Servicio de Oncologia
Valencia , 46017, Spain
Hospital Universitario Miguel Servet; Servicio Oncologia
Zaragoza , 50009, Spain
China Medical University Hospital; Surgery
Taichung , 404, Taiwan
National Cheng Kung Uni Hospital; Dept of Hematology and Oncology
Tainan , 704, Taiwan
National Taiwan University Hospital ; Dept of Surgery & Hepatitis Research Center
Taipei 100 , 100, Taiwan
Taipei Veterans General Hospital; Department of Clinical Trial Pharmacy
Taipei , 00112, Taiwan
Mackay Memorial Hospital; Dept of Surgery
Taipei , 104, Taiwan
Chulalongkorn Hospital; Medical Oncology
Bangkok , 10330, Thailand
Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc
Bangkok , 10400, Thailand
Srinagarind Hospital; Department of Surgery
Khon Kaen , 40002, Thailand
Songklanagarind Hospital; Department of Surgery
Songkla , 90110, Thailand
Adana Baskent University Hospital; Medical Oncology
Adana , 01120, Turkey
Hacettepe University Medical Faculty
Ankara , 06100, Turkey
Ankara City Hospital
Ankara , 06490, Turkey
Memorial Ankara Hastanesi
Ankara , 06520, Turkey
Antalya Training and Research Hospital ; Oncology Department
Antalya , 07100, Turkey
Ege University Medical Faculty; Medical Oncology Department
Bornova, İ̇zmi̇r , 35100, Turkey
Dicle University Faculty of Medicine
Diyarbakir , 21280, Turkey
Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi
Edirne , 22030, Turkey
Istanbul Faculty of Medicine
Istanbul , 34093, Turkey
Istanbul University Cerrahpasa Faculty of Medicine
Istanbul , 34098, Turkey
Katip Celebi University Ataturk Training and Research Hospital; Oncology
Izmir , 35360, Turkey
Medeniyet University Goztepe Training and Research Hospital.
Kadiköy , 34722, Turkey
Inonu University Medical Faculty of Medicine; Medical Oncology Department
Malatya , 44280, Turkey
Acıbadem Altunizade Hastanesi; Oncology
Üsküdar , 34662, Turkey
Uzhgorod Central City Clinical Hospital
Uzhhorod Katerynoslav Governorate, 88000, Ukraine
Municipal Noncommercial Institution Regional Center of Oncology
Kharkiv Kharkiv Governorate, 61070, Ukraine
Municipal non profit enterprise of Sumy Regional Council Sumy Regional Clinical Oncology Disp
Sumy Kholm Governorate, 40005, Ukraine
MI "Clinical Oncological Dispensary" of Dnipro Reg Council; chemotherapy department
Dnipro KIEV Governorate, 49100, Ukraine
Innovacia Cancer Center
Liutizh KIEV Governorate, 07352, Ukraine
CI Dnipropetrovsk CMCH #4 of Dnipropetrovsk RC SI Dnipropetrovsk MA of MOHU Ch of Oncology and MR
Dnipropetrovsk , 49102, Ukraine
Municipal Institution Kirovograd Regional Oncology Dispensary
Kirovograd , 25011, Ukraine
Kyiv City Clinical Oncological Center
Kyiv , 03115, Ukraine
Belfast City Hospital
Belfast , BT9 7, United Kingdom
Blackpool Victoria Hospital
Blackpool , FY3 8, United Kingdom
Bradford Royal Infirmary; Oncology Department
Bradford , BD9 6, United Kingdom
Royal Sussex County Hospital
Brighton , BN2 5, United Kingdom
Addenbrookes Hospital
Cambridge , CB2 0, United Kingdom
Velindre Cancer Centre; Clinical Trials Unit
Cardiff , CF14 , United Kingdom
Cheltenham General Hospital
Cheltenham , GL53 , United Kingdom
Royal Cornwall Hospital; Dept of Clinical Oncology
Cornwall , TR1 3, United Kingdom
Hairmyres Hospital
East Kilbride , G75 8, United Kingdom
Raigmore Hospital
Inverness , IV2 3, United Kingdom
Barts & London School of Med; Medical Oncology
London , EC1A , United Kingdom
University College London Hospital
London , NW1 -, United Kingdom
Royal Free Hospital
London , NW3 2, United Kingdom
Royal Marsden Hospital - London
London , SW3 6, United Kingdom
Christie Hospital NHS Trust
Manchester , M20 4, United Kingdom
Nottingham City Hospital
Nottingham , NG5 1, United Kingdom
Royal Preston Hospital
Preston , PR2 9, United Kingdom
Glan Clywd Hospital
Rhyl , LL18 , United Kingdom
Royal Marsden Hospital - Surrey
Surrey , SM2 5, United Kingdom
Walsall Manor Hospital
Walsall , WS2 9, United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Phase:

Phase 3

Estimated Enrollment:

1700

Study ID:

NCT04873362

Recruitment Status:

Recruiting

Sponsor:


Hoffmann-La Roche

How clear is this clinincal trial information?

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