Breast Cancer Clinical Trial

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A Study of Changes in Ki67 Expression in People With Breast Cancer Receiving Endocrine Therapy Before Surgery

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Summary

The researchers are doing this study to look at changes in Ki67 expression after at least 2 weeks of endocrine therapy in people with ER+/HER2- breast cancer undergoing cancer removal surgery. Participants will receive the endocrine therapy before their surgery. The researchers will look at how changes in Ki67 expression compare between participants who are carriers of the BRCA2 mutation and participants who are noncarriers of the BRCA2 mutation.

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Eligibility Criteria

Inclusion Criteria:

Women aged ≥18 years with biopsy-proven stage I-III invasive breast cancer that is ER+/HER2-
Scheduled to undergo upfront surgery
Eligible for genetic testing in accordance with National Comprehensive Cancer Network guidelines

Exclusion Criteria:

History of breast cancer
Receipt of ET for risk reduction in the previous 3 months
Stage IV disease at presentation
Scheduled to undergo neoadjuvant systemic chemotherapy
Pregnant

Study is for people with:

Breast Cancer

Estimated Enrollment:

42

Study ID:

NCT06127979

Recruitment Status:

Recruiting

Sponsor:

Memorial Sloan Kettering Cancer Center

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There is 1 Location for this study

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Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York New York, 10065, United States More Info
Minna Lee, MD
Contact
646-888-6898

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Estimated Enrollment:

42

Study ID:

NCT06127979

Recruitment Status:

Recruiting

Sponsor:


Memorial Sloan Kettering Cancer Center

How clear is this clinincal trial information?

Clinical Trial Resources

SurvivorNet’s Guide To Clinical Trials: What Are They And Are They Right for You?
Clinical Trials for Breast Cancer
Have You Been Diagnosed With Late-Stage Breast Cancer? Know That You Have Treatment Options.
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