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A Study of Changes in Ki67 Expression in People With Breast Cancer Receiving Endocrine Therapy Before Surgery Summary The researchers are doing this study to look at changes in Ki67 expression after at least 2 weeks of endocrine therapy in people with ER+/HER2- breast cancer undergoing cancer removal surgery. Participants will receive the endocrine therapy before their surgery. The researchers will look at how changes in Ki67 expression compare between participants who are carriers of the BRCA2 mutation and participants who are noncarriers of the BRCA2 mutation.
View Eligibility Criteria Eligibility Criteria Inclusion Criteria: Women aged ≥18 years with biopsy -proven stage I-III invasive breast cancer that is ER+/HER2- Scheduled to undergo upfront surgery Eligible for genetic testing in accordance with National Comprehensive Cancer Network guidelines Exclusion Criteria: History of breast cancer Receipt of ET for risk reduction in the previous 3 months Stage IV disease at presentation Scheduled to undergo neoadjuvant systemic chemotherapy Pregnant
Check Your Eligibility
Let’s see if you might be eligible for this study.
What is your age and gender ?
There is 1 Location for this study
Memorial Sloan Kettering Cancer Center (All Protocol Activities) New York New York, 10065, United States
More Info How clear is this clinincal trial information?
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