A Study of SGN-PDL1V in Advanced Solid Tumors

Inclusion Criteria:

Parts A and B:

Participants must have one of the following histologically- or cytologically-confirmed metastatic or unresectable solid tumor types

Non-small cell lung cancer (NSCLC)
Head and neck squamous cell carcinoma (HNSCC)
Esophageal squamous cell carcinoma (SCC)
Triple negative breast cancer (TNBC)
Participants must have disease that is relapsed or refractory, that has progressed on approved therapies, be intolerant to or refused such therapies, or such and therapies are contraindicated and in the judgement of the investigator, should have no appropriate SoC therapeutic option
Participants must have PD-L1 expression based on historical testing

Part C:

Participants must have disease that is relapsed or refractory or be intolerant to SoC therapies and must have one of the following tumor types

HNSCC

Participants with HNSCC must have histologically or cytologically-confirmed HNSCC

NSCLC

Participants must have histologically or cytologically-confirmed NSCLC
Esophageal SCC
Ovarian cancer
Melanoma
TNBC
Gastric cancer
Participants must have been previously tested for PD-L1 expression and should have PD-L1 expression ≥1 or <1 by CPS or TPS based on historical testing

Part D:

Participants must have histologically or cytologically-confirmed disease of the HNSCC
Participants must have PD-L1 expression based on historical testing
Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1
Measurable disease per RECIST v1.1 at baseline

Exclusion Criteria:

History of another malignancy within 3 years of first dose of study treatment or any evidence of residual disease from a previously diagnosed malignancy.

Known active central nervous system metastases. Participants with previously-treated brain metastases may participate provided they:

Are clinically stable for at least 4 weeks prior to study entry after brain metastasis treatment
Have no new or enlarging brain metastases
And are off of corticosteroids prescribed for symptoms associate with brain metastases for at least 7 days prior to first dose of study treatment
Lepto-meningeal disease
Prior treatment with an anti-PD-L1 agent within less than 5 half-lives. This duration of time will vary according to the half-life of the specific agent.
Previous receipt of an monomethylauristatin E (MMAE)-containing agent.
Pre-existing neuropathy ≥Grade 2 per National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) v5.0.

There are additional inclusion criteria. The study center will determine if criteria for participations are met.