Breast Cancer Clinical Trial

A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer

Summary

This study is being done to see if tucatinib with ado-trastuzumab emtansine (T-DM1) works better than T-DM1 alone to help patients who have a specific type of breast cancer called HER2 positive breast carcinoma. The breast cancer in this study is either metastatic (spread into other parts of the body) or cannot be removed completely with surgery.

Patients in this study will be randomly assigned to get either tucatinib or placebo (a pill with no medicine). This is a blinded study, so neither patients nor their doctors will know whether a patient gets tucatinib or placebo. All patients in the study will get T-DM1, a drug that is often used to treat this cancer.

Each treatment cycle lasts 21 days. Patients will swallow tucatinib pills or placebo pills two times every day. Patients will get T-DM1 injections from the study site staff on the first day of every cycle.

View Full Description

Full Description

This study is designed to evaluate the efficacy and safety of tucatinib in combination with T-DM1 in subjects with unresectable locally-advanced or metastatic HER2+ breast cancer who have had prior treatment with a taxane and trastuzumab in any setting. Prior pertuzumab treatment is permitted, but not required. Subjects will be randomized in a 1:1 manner to receive 21-day cycles of either tucatinib or placebo in combination with T-DM1.

While on study treatment, subjects will be assessed for progression every 6 weeks for the first 24 weeks, and every 9 weeks thereafter, irrespective of dose holds or interruptions. Study treatment will continue until unacceptable toxicity, disease progression, withdrawal of consent, or study closure. After completion of study treatment and after occurrence of disease progression, subjects in both arms of the study will continue to be followed for survival until study closure or withdrawal of consent.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Histologically confirmed HER2+ breast carcinoma as determined by a sponsor-designated central laboratory
History of prior treatment with a taxane and trastuzumab in any setting, separately or in combination
Have progression of unresectable locally advanced/metastatic breast cancer after last systemic therapy, or be intolerant of last systemic therapy
Measurable or non-measurable disease assessable by RECIST v1.1
ECOG performance status score of 0 or 1

CNS Inclusion - Based on screening contrast brain magnetic resonance imaging (MRI), subjects must have at least one of the following:

(a) No evidence of brain metastases

(b) Untreated brain metastases not needing immediate local therapy

(c) Previously treated brain metastases

Brain metastases previously treated with local therapy may either be stable since treatment or may have progressed since prior local CNS therapy, provided that there is no clinical indication for immediate re-treatment with local therapy

Subjects treated with CNS local therapy for newly identified lesions or previously treated and progressing lesions may be eligible to enroll if all of the following criteria are met:

(i) Time since SRS is at least 7 days prior to first dose of study treatment, time since WBRT is at least 21 days prior to first dose, or time since surgical resection is at least 28 days.

(ii) Other sites of evaluable disease are present

Relevant records of any CNS treatment must be available to allow for classification of target and non-target lesions

Exclusion Criteria:

Prior treatment with tucatinib, afatinib, trastuzumab deruxtecan (DS-8201a), or any other investigational anti-HER2, anti-EGFR, or HER2 TKI agent. Prior treatment with lapatinib or neratinib within 12 months of starting study treatment (except in cases where they were given for ≤21 days and was discontinued for reasons other than disease progression or severe toxicity). Prior treatment with pyrotinib for recurrent of mBC (except in cases where pyrotinib was given for ≤21 days and was discontinued for reasons other than disease progression or severe toxicity).

CNS Exclusion - Based on screening contrast brain magnetic resonance imaging (MRI), subjects must not have any of the following:

Any untreated brain lesions >2 cm in size
Ongoing use of corticosteroids for control of symptoms of brain metastases at a total daily dose of >2 mg of dexamethasone (or equivalent).
Any brain lesion thought to require immediate local therapy
Known or concurrent leptomeningeal disease as documented by the investigator
Poorly controlled generalized or complex partial seizures

Study is for people with:

Breast Cancer

Phase:

Phase 3

Estimated Enrollment:

565

Study ID:

NCT03975647

Recruitment Status:

Recruiting

Sponsor:

Seagen Inc.

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There are 249 Locations for this study

See Locations Near You

University of South Alabama - Mitchell Cancer Institute
Mobile Alabama, 36604, United States
Ironwood Cancer & Research Centers - Chandler
Chandler Arizona, 85224, United States
Banner MD Anderson Cancer Center
Gilbert Arizona, 85234, United States
Cancer Treatment Centers of America / Western Regional Medical Center
Goodyear Arizona, 85338, United States
Arizona Oncology Associates, PC - HAL
Phoenix Arizona, 85016, United States
Arizona Oncology Associates, PC - HOPE
Tucson Arizona, 85710, United States
St. Bernards Medical Center
Jonesboro Arkansas, 72401, United States
St. Bernards Medical Center
Jonesboro Arkansas, 92835, United States
City of Hope National Medical Center
Duarte California, 91010, United States
California Cancer Associates for Research and Excellence Inc (cCARE)
Encinitas California, 92024, United States
St. Joseph Heritage Healthcare TRIO
Fullerton California, 92835, United States
Chao Family Comprehensive Cancer Center University of California Irvine
Orange California, 92868, United States
University of California Irvine - Newport
Orange California, 92868, United States
University of California Davis
Sacramento California, 95817, United States
San Francisco General Hospital
San Francisco California, 94110, United States
University of California at San Francisco
San Francisco California, 94134, United States
UCLA Medical Center / David Geffen School of Medicine
Santa Monica California, 90404, United States
Torrance Memorial Physician Network - TRIO
Torrance California, 90505, United States
Kaiser Permanente Medical Center Northern California
Vallejo California, 94589, United States
Rocky Mountain Cancer Centers - Aurora
Aurora Colorado, 80012, United States
University of Colorado Hospital / University of Colorado
Aurora Colorado, 80045, United States
SCL Health Good Samaritan Medical Center Cancer Centers of Colorado
Broomfield Colorado, 80021, United States
University of Colorado Health Memorial Hospital
Colorado Springs Colorado, 80909, United States
Cancer Centers of Colorado - Denver
Denver Colorado, 80218, United States
Poudre Valley Health System (PVHS)
Fort Collins Colorado, 80524, United States
Helen F. Graham Cancer Center / Christiana Care Health Systems
Newark Delaware, 19713, United States
Lombardi Cancer Center / Georgetown University Medical Center
Washington District of Columbia, 20007, United States
Florida Cancer Specialists - South Region
Fort Myers Florida, 33901, United States
Baptist MD Anderson Cancer Center
Jacksonville Florida, 32207, United States
University of Miami
Miami Florida, 33136, United States
Miami Cancer Institute at Baptist Health, Inc.
Miami Florida, 33176, United States
AdventHealth Cancer Institute
Orlando Florida, 32804, United States
Orlando Health, Inc. TRIO
Orlando Florida, 32806, United States
Florida Cancer Specialists - North Region
Saint Petersburg Florida, 33705, United States
H. Lee Moffitt Cancer Center and Research Institute
Tampa Florida, 33612, United States
Florida Cancer Specialists - East West Palm Beach, FL (SCRI)
West Palm Beach Florida, 33401, United States
Winship Cancer Institute / Emory University School of Medicine
Atlanta Georgia, 30322, United States
Northside Hospital
Atlanta Georgia, 30342, United States
Augusta University
Augusta Georgia, 30912, United States
Kaiser Permanente Moanalua Medical Center
Honolulu Hawaii, 96819, United States
Kapi'olani Medical Center for Women and Children
Honolulu Hawaii, 96826, United States
Illinois Cancer Specialists - Arlington Heights
Arlington Heights Illinois, 60005, United States
Rush University Medical Center
Chicago Illinois, 60612, United States
University of Chicago Medical Center
Chicago Illinois, 60637, United States
Illinois Cancer Care
Peoria Illinois, 61615, United States
Ft Wayne Medical Oncology and Hematology, Inc TRIO
Fort Wayne Indiana, 46804, United States
University of Kansas Medical Center
Kansas City Kansas, 66160, United States
CHI Saint Joseph Medical Group Cancer Care Center
Lexington Kentucky, 40509, United States
Ochsner Medical Center
New Orleans Louisiana, 70121, United States
University of Maryland
Baltimore Maryland, 21201, United States
Mercy Medical Center -Weinberg Center
Baltimore Maryland, 21202, United States
American Oncology Networks LLC
Bethesda Maryland, 20817, United States
Maryland Oncology Hematology, P.A.
Rockville Maryland, 20850, United States
Beth Israel Deaconess Medical Center
Boston Massachusetts, 02215, United States
Dana Farber Cancer Institute
Boston Massachusetts, 02215, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor Michigan, 48109, United States
Henry Ford Health System
Detroit Michigan, 48202, United States
Minnesota Oncology Hematology P.A.
Minneapolis Minnesota, 55404, United States
North Mississippi Medical Center Hematology Oncology - Tupelo
Tupelo Mississippi, 38801, United States
Saint Luke's Cancer Institute LLC
Kansas City Missouri, 64113, United States
HCA Midwest Health Kansas City
Kansas City Missouri, 64132, United States
Washington University in St Louis
Saint Louis Missouri, 63110, United States
St. Vincent Frontier Cancer Center
Billings Montana, 59102, United States
Nebraska Cancer Specialists
Omaha Nebraska, 68130, United States
Comprehensive Cancer Centers of Nevada
Las Vegas Nevada, 89169, United States
Summit Medical Group
Florham Park New Jersey, 07932, United States
Saint Barnabas Medical Center Cancer Center
Livingston New Jersey, 07039, United States
Rutgers Cancer Institute of New Jersey
New Brunswick New Jersey, 08903, United States
New York Oncology Hematology, P.C.
Albany New York, 12206, United States
Stony Brook University Cancer Center
Stony Brook New York, 11794, United States
UNC Lineberger Comprehensive Cancer Center / University of North Carolina
Chapel Hill North Carolina, 27599, United States
Levine Cancer Institute
Charlotte North Carolina, 28204, United States
Duke University Medical Center
Durham North Carolina, 27710, United States
Providence Portland Medical Center
Portland Oregon, 97213, United States
Oregon Health and Science University
Portland Oregon, 97239, United States
Northwest Cancer Specialists, P.C.
Tigard Oregon, 97223, United States
University of Pennsylvania / Perelman Center for Advanced Medicine
Philadelphia Pennsylvania, 19104, United States
Cancer Treatment Centers of America / Eastern Regional Medical Center
Philadelphia Pennsylvania, 19124, United States
Brig Center for Cancer Care and Survivorship
Knoxville Tennessee, 37909, United States
Tennessee Oncology - Nashville
Nashville Tennessee, 37203, United States
Texas Oncology - Amarillo
Amarillo Texas, 79106, United States
Texas Oncology - Austin Central
Austin Texas, 78731, United States
Texas Oncology - Bedford
Bedford Texas, 76022, United States
Texas Oncology - Methodist Dallas Cancer Center
Dallas Texas, 75203, United States
Texas Oncology - Medical City Dallas
Dallas Texas, 75230, United States
Texas Oncology - Baylor Sammons Cancer Center
Dallas Texas, 75246, United States
University of Texas Southwestern Medical Center
Dallas Texas, 75390, United States
The Center for Cancer and Blood Disorders: Fortworth
Fort Worth Texas, 76104, United States
Texas Oncology - Houston Memorial City
Houston Texas, 77024, United States
MD Anderson Cancer Center / University of Texas
Houston Texas, 77030, United States
Baylor Clinic
Houston Texas, 77030, United States
Oncology Consultants, PA
Houston Texas, 77030, United States
Texas Oncology - San Antonio Medical Center
San Antonio Texas, 78240, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City Utah, 84112, United States
Virginia Cancer Specialists, PC
Fairfax Virginia, 22031, United States
Saint Francis Hospital / Bon Secours - Virginia
Midlothian Virginia, 23114, United States
Peninsula Cancer Institute
Newport News Virginia, 23601, United States
Oncology and Hematology Assoc of SW VA DBA Blue Ridge Cancer Care
Salem Virginia, 24153, United States
Swedish Cancer Institute - Edmonds
Edmonds Washington, 98026, United States
Swedish Cancer Institute - Issaquah
Issaquah Washington, 98029, United States
Swedish Cancer Institute
Seattle Washington, 98104, United States
Peter MacCallum Cancer Centre
Melbourne Other, 3000, Australia
Austin Health
Melbourne Other, 3084, Australia
Breast Cancer Research Centre
Nedlands Other, 6009, Australia
Mater Hospital
Sydney Other, 2060, Australia
Westmead Hospital
Westmead Other, 2145, Australia
LKH- Universitat Klinikum Graz
Graz Other, 8036, Austria
Medizinische Universitat Innsbruck
Innsbruck Other, 6020, Austria
LKH Salzburg, Universitatsklinikum der PMU
Salzburg Other, 5020, Austria
Medizinische Universitat Wien
Vienna Other, 1090, Austria
Klinik Ottakring
Vienna Other, 1160, Austria
Institut Jules Bordet
Anderlecht Other, B-107, Belgium
Cliniques Universitaires Saint Luc
Brussels Other, 1200, Belgium
Grand Hôpital de Charleroi - Saint-Joseph
Charleroi Other, 6000, Belgium
Universitair Ziekenhuis Antwerpen
Edegem Other, 2650, Belgium
Academisch Ziekenhuis Groeninge
Kortrijk Other, 8500, Belgium
CHU de Liege
Liege Other, 4000, Belgium
Universitair Ziekenhuis Leuven
Lueven Other, 3000, Belgium
CHU UCL Namur-Site de Saint Elisabeth
Namur Other, 5000, Belgium
University of Alberta / Cross Cancer Institute
Edmonton Alberta, T6G 1, Canada
Queen Elizabeth II Health Sciences Centre
Halifax Nova Scotia, B3H 2, Canada
Cancer Centre of Southeastern Ontario At Kingston General Hospital
Kingston Ontario, K7L 5, Canada
London Health Sciences Centre - Victoria Hospital
London Ontario, N6A 5, Canada
University of Ottawa / Ottawa General Hospital
Ottawa Ontario, K1H 8, Canada
University Health Network, Princess Margaret Hospital
Toronto Ontario, M5G 2, Canada
Centre de Recherche du Centre Hospitalier de l'Universite de Montreal
Montreal Quebec, H2X 0, Canada
Jewish General Hospital
Montreal Quebec, H3T 1, Canada
Saskatoon Cancer Centre
Saskatoon Saskatchewan, S7N 4, Canada
Hopital du Saint-Sacrement, CHU de Quebec-Universite Laval
Quebec , G1S 4, Canada
Cancer Hospital Chinese Academy of Medical Sciences
Beijing City Other, 10002, China More Info
Binghe Xu
Principal Investigator
Zhejiang Cancer Hospital
Hangzhou City Other, 31002, China More Info
Xiaojia Wang
Principal Investigator
First Affiliated Hospital of Zhejiang University
Hangzhou City Other, , China More Info
Peng Shen
Principal Investigator
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou Other, 0571, China More Info
Yiding Chen
Principal Investigator
Nanchang Third Hospital
Nanchang City Other, 33000, China More Info
Hong Wang
Principal Investigator
Gulou Hospital Affiliated to Nanjing University Medical College
Nanjing Other, 21000, China More Info
Li Xie
Principal Investigator
Tianjin Medical University - Cancer Institute & Hospital
Tianjin Other, 45300, China More Info
Zhongsheng Tong
Principal Investigator
Hubei Cancer Hospital
Wuhan Other, 43000, China More Info
Xinhong Wu
Principal Investigator
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an Other, 71006, China More Info
Jin Yang
Principal Investigator
Xi'An International Medical Center Hospital
Xi'An Other, 71010, China More Info
Xue Yan
Principal Investigator
The Affiliated Hospital of Guangdong Medical University
Zhan Jiang City Other, 52400, China More Info
Ying Zhang
Principal Investigator
Aalborg Universitetshospital
Aalborg Other, 9100, Denmark
Aarhus University Hospital
Aarhus N Other, 8200, Denmark
Rigs Hospiltalet
Copenhagen Other, 2100, Denmark
Herlev Hospital
Herlev Other, 2730, Denmark
Odense University Hospital
Odense C Other, 5000, Denmark
Sygehus Lillebaelt - Vejle Sygehus
Vejle Other, 7100, Denmark
University Hospital of Besancon
Besancon cedex Other, 25030, France
Hospital Center Regional University Morvan De Brest
Brest Other, 29200, France
Centre de Lutte contre le Cancer - François Baclesse
Caen Cedex 5 Other, 14076, France
Hopital Europeen Georges Pompidou
Cedex 15 Other, 75908, France
Center Georges Francois Leclerc
Dijon Other, 21000, France
Clinique Victor Hugo Le Mans
Le Mans Other, 72000, France
Centre Leon Berard - Centre regional de lutte contre le cancer Rhone-Alpes
Lyon Other, 69008, France
Institut Paoli Calmettes
Marseille Other, 13273, France
Hopital Saint-Louis / Service d'Hematologie
Paris Cedex 10 Other, 75475, France
Institute Curie - Centre de Lutte Contre Le Cancer CLCC de Paris
Paris Other, 75298, France
Centre Henri Becquerel / Centre Regional de Lutte Contre le Cancer
Rouen Other, 76038, France
Hopitaux Universitaires de Strasbourg
Strasbourg Other, 67200, France
Institut Claudius Regaud IUCT-O
Toulouse Cedex 9 Other, 31059, France
CHU Tours - Hopital Bretonneau
TOURS Cedex 09 Other, 37044, France
Helios Klinikum Berlin-Buch
Berlin Other, 13125, Germany
Stadtisches Klinikum Dessau
Dessau-Rosslau Other, 06847, Germany
Kliniken Essen-Mitte - Evang. Huyssens-Stiftung
Essen Other, 45136, Germany
CHOP GmbH
Frankfurt Other, 60389, Germany
Universitaetsklinikum Hamburg-Eppendorf (UKE)
Hamburg Other, 20246, Germany
Universitatsklinikum Heidelberg
Heidelberg Other, 69120, Germany
Universitatsklinikum Schleswig-Holstein
Kiel Other, 24105, Germany
InVO- Institut fUr Versorgungsforschung in der onkologie GbR
Koblenz Other, 56068, Germany
Universitatsmedizin der Johannes Gutenberg-Universitat Mainz
Mainz Other, 55101, Germany
Klinikum der Universitat Munchen
Munchen Other, 80337, Germany
Klinikum Rechts der Isar der Technischen Universitat Munchen
Munchen Other, 81675, Germany
Sana Klinikum Offenbach GmbH
Offenbach am Main Other, 63069, Germany
University of Rostock
Rostock Other, 18059, Germany
Shaare Zedek Medical Center
Jerusalem Other, 91031, Israel
Meir Medical Center
Kfar Saba Other, 44281, Israel
Rabin Medical Center
Petach Tikva Other, 49414, Israel
Kaplan Medical Center
Rehovot Other, 76100, Israel
Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi
Bologna Other, 40138, Italy
Fondazione del Piemonte per l'Oncologia - Istituto di Candiolo FPO - IRCCS
Candiolo Other, 10060, Italy
Irccs Irst
Meldola Other, 47014, Italy
Istituto Europeo di Oncologia
Milano Other, 20141, Italy
Seconda Università degli Studi di Napoli, AOU
Napoli Other, 80131, Italy
Nuovo Ospedale di Prato - Santo Stefano
Prato Other, 59100, Italy
Ospedale degli Infermi
Rimini Other, 47923, Italy
Policlinico Universitario Agostino Gemelli
Roma Other, 00168, Italy
Azienda Ospedaliera S. Maria di Terni
Terni Other, 05100, Italy
A.O.U. - Ospedali Riuniti di Ancona
Torrette Other, 60126, Italy
Chiba Cancer Center
Chiba Other, 260-8, Japan
National Cancer Center Hospital East
Chiba Other, 277-8, Japan
National Cancer Center Hospital
Chuo-ku Other, 104-0, Japan
National Hospital Organization Kyushu Cancer Center
Fukuoka Other, 811-1, Japan
Hiroshima City Hiroshima Citizens Hospital
Hiroshima Other, 730-8, Japan
University of Tsukuba Hospital
Ibaraki Other, 305-8, Japan
Hakuaikai Sagara Hospital/Breast Surgery
Kagosima Other, 892-0, Japan
Kameda General Hospital
Kamogawa Other, 296-8, Japan
Saitama Cancer Center
Kitaadachi-gun Other, 362-0, Japan
Kumamoto Shinto General Hospital
Kumamoto Other, 862-8, Japan
Shikoku Cancer Center
Matsuyama Other, 791-0, Japan
Aichi Cancer Center
Nagoya-shi Other, 464-8, Japan
Hyogo College of Medicine Hospital
Nishinomiya Other, 730-8, Japan
National Hospital Organization Osaka
Osaka Other, 540-0, Japan
Osaka International Cancer Institute
Osaka Other, 541-8, Japan
Hokkaido Cancer Center
Sapporo Other, 003-0, Japan
Shizuoka Cancer Center
Sunto-Gun Other, 411-8, Japan
The Cancer Institute Hospital of JFCR
Tokyo Other, 135-8, Japan
Kanagawa Cancer Center
Yokohama Other, 241-8, Japan
National Cancer Center
Goyang-si Other, 10408, Korea, Republic of
Seoul National University Bundang Hospital
Seongnam-si Other, 13605, Korea, Republic of
Severance Hospital, Yonsei University Health System
Seoul Other, 03722, Korea, Republic of
Asan Medical Center - Oncology
Seoul Other, 05505, Korea, Republic of
Samsung Medical Center
Seoul Other, 06351, Korea, Republic of
Seoul National University Hospital
Seoul Other, 110-7, Korea, Republic of
Korea University Anam Hospital
Seoul Other, 2841, Korea, Republic of
Isala Ziekenhuis Zwolle
AB Zwolle Other, 8025, Netherlands
Netherlands Cancer Institute
Amsterdam Other, 1066 , Netherlands
Amphia Ziekenhuis
Breda Other, 4818 , Netherlands
Reinier de Graaf Hospital
Delft Other, 2625, Netherlands
University Medical Center Groningen
Groningen Other, 9713 , Netherlands
Martini Ziekenhuis
Groningen Other, 9728, Netherlands
Maastricht University Medical Center
Maastricht Other, 6229 , Netherlands
Erasmus Medisch Centrum Daniel Den Hoed
Rotterdam Other, 3015G, Netherlands
National University Cancer Institute, Singapore
Singapore Other, 11922, Singapore
National Cancer Centre
Singapore Other, 16961, Singapore
Hospital del Mar
Barcelona Other, 08003, Spain
Hospital Universitario Vall d'Hebron
Barcelona Other, 08035, Spain
Hospital Universitario Reina Sofia
Cordoba Other, 14004, Spain
Hospital General Universitario Gregorio Marañon
Madrid Other, 28007, Spain
Hospital Ruber Internacional
Madrid Other, 28034, Spain
Hospital Clínico San Carlos
Madrid Other, 28040, Spain
Hospital Universitario HM Sanchinarro
Madrid Other, 28050, Spain
Hospital Universitario Virgen de la Victoria
Malaga Other, 29010, Spain
Hospital Son Espases
Palma de Mallorca Other, 07120, Spain
Institut Catala D'Oncologia Hospitalet
Saint Joan Despi Other, 08970, Spain
Hospital Universitario de Canarias
San Cristóbal de la Laguna Other, 38320, Spain
Hospital Universitario Virgen del Rocio
Sevilla Other, 41013, Spain
Hospital Clinico Universitario de Valencia
Valencia Other, 46010, Spain
Hospital Universitario Miguel Servet
Zaragoza Other, 50009, Spain
Goteborgs Universitet - Sahlgrenska Akademin - Institutionen For Kliniska Vetenskaper (Institute Of Clinical Sciences)
Gothenburg Other, SE-40, Sweden
Ryhov Hospital
Jonkoping Other, 55185, Sweden
Skanes University Hospital - Universitetssjukhus
Lund Other, 22185, Sweden
Orebro University Hospital
Orebro Other, 70185, Sweden
Onkologklinike Sodersjukhuset
Stockholm Other, S-118, Sweden
University Hospital Basel - Brustzentrum
Basel Other, 4031, Switzerland
Institute of Oncology of Southern Switzerland
Bellinzona Other, 6500, Switzerland
University Hospital Lausanne CHUV
Lausanne Other, 1011, Switzerland
Kantonsspital Winterthur (KSW)
Winterthur Other, 8401, Switzerland
National Cheng-Kung University Hospital
Tainan Other, 704, Taiwan
National Taiwan University Hospital
Tainan Other, 704, Taiwan
University Hospitals Birmingham NHS Foundation Trust
Birmingham Other, B15 2, United Kingdom
Addenbrooke's Hospital
Cambridge Other, CB2 0, United Kingdom
The University of Edinburgh
Edinburgh Other, EH4 2, United Kingdom
Oxford University Hospitals
Headington Other, OX3 7, United Kingdom
The Royal Marsden NHS Foundation Trust (RM)
London Other, SW3 6, United Kingdom
Sarah Cannon Research Institute UK
London Other, W1G 6, United Kingdom
Maidstone and Tunbridge Wells NHS Trust
Maidstone Other, ME16 , United Kingdom
The Christie NHS Foundation Trust
Manchester Other, M20 4, United Kingdom
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle Upon Tyne Other, NE7 7, United Kingdom
Mount Vernon Hospital, UK
Northwood Other, HA6 2, United Kingdom
The Royal Marsden Hospital (Surrey)
Sutton Other, SM2 5, United Kingdom
Royal Cornwall Hospitals NHS Trust
Truro Other, TR1 3, United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Phase:

Phase 3

Estimated Enrollment:

565

Study ID:

NCT03975647

Recruitment Status:

Recruiting

Sponsor:


Seagen Inc.

How clear is this clinincal trial information?

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