AGE Levels in ER+ Metastatic Breast Cancer Patients Receiving Endocrine Therapy

Inclusion Criteria:

Must have ER+ breast cancer
Metastatic disease; protocol does allow for bone-only disease
Must be receiving endocrine therapy
Must have completed at last 2 months of current endocrine therapy prior to registration
Must have adequate hematologic, renal and hepatic function
Prior/concurrent radiation therapy is allowed
Prior chemotherapy is allowed, but last dose must have been at least 2 months prior to enrollment
May have diabetes, but must not be taking metformin
Must be able to swallow and retain oral medication
Performance status of 0-2
Treated stable brain metastases are allowed, as long as patient does not require steroids or anti-seizure medications
Must be informed of the investigational nature of this study and must have the ability to sign informed consent.

Exclusion Criteria:

Known allergy to grapes or grape seed
More than two prior endocrine therapy regimens for the treatment of metastatic ER+ breast cancer.
Concurrent use of restricted agents outlined in section 4.5.
History of alcohol abuse within 2 years of registration.