Breast Cancer Clinical Trial
CESM ABMR Breast Cancer Screening Trial
Summary
This is a single institution, prospective screening trial of women at high risk for developing breast cancer, enriched with women with suspicious lesions on breast MRI which have been recommended for biopsy.
Primary Aim: Measure and compare the diagnostic performance of CESM, ABMR, and standard breast MRI, using the following performance measures: cancer detection rate (CDR), biopsy rate, and cancer yield of biopsy (also known as positive predictive value 3 or PPV3).
Secondary Aims:
Compare screening performance outcome measures of sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) for CESM, ABMR, and standard breast MRI. This will determine the feasibility of each modality as an alternative to standard breast MRI and provide valuable pilot data for designing a larger clinical trial to evaluate non-inferiority of either or both modalities.
Breast cancer characteristics (size, histologic subtype, node-positivity, AJCC stage) will be assessed in the overall cohort, and stratified by mode of detection for each modality(screen-detected versus interval).
Eligibility Criteria
Inclusion Criteria:
Able and willing to provide signed declaration of informed consent or have a legally authorized representative provide signed declaration of informed consent for participation in all study procedures;
Women aged ≥18 years at the time of enrollment
Referred clinically for breast MRI for any indication
Exclusion Criteria:
Known allergy or contraindication to iodinated contrast
Are currently pregnant based on urine pregnancy test
Have breast implants
Are lactating
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There is 1 Location for this study
Seattle Washington, 98102, United States
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