Chemotherapy-Induced Changes to Cognition and DNA in Breast Cancer Survivors

Inclusion Criteria:

Breast cancer survivors (Stage I-III) 2-6 years post all cancer treatments, but currently receiving hormone therapy.
History of treatment with chemotherapy and/or hormonal therapy, or hormone therapy only.
No evidence of active/recurrent disease.
Less than 70 years old at time of recruitment.
Post-menopausal prior to initial treatment.
In the judgment of the consenting professional, is able to provide informed consent.
Patient is able to understand English, through verbal and written communication.

Exclusion Criteria:

Recurrence of breast cancer or diagnosis of another cancer except basal cell carcinoma.
Exposure to chemotherapy or radiation therapy for any medical condition unrelated to breast cancer.
Neurobehavioral risk factors including history of neurological disorder, or moderate to severe head trauma (loss of consciousness > 60 min or evidence of structural brain changes on imaging).
Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, etc.
Self-reported sleep disorders that could influence cognitive functioning including sleep apnea and chronic fatigue syndrome.
Self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia.
Disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia.
Male.

Healthy Control Inclusion Criteria:

Have had no diagnosis of cancer except basal cell carcinoma.
Less than 70 years old at time of recruitment.
Post-menopausal.
In the judgment of the consenting professional, is able to provide informed consent.
Patient is able to understand English, through verbal and written communication

Healthy Control Exclusion Criteria:

Exposure to chemotherapy or radiation therapy for any medical condition.
Neurobehavioral risk factors including history of neurological disorder, or moderate to severe head trauma (loss of consciousness > 60 min or evidence of structural brain changes on imaging).
Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis etc.
Self-reported sleep disorders that could influence cognitive functioning including sleep apnea and chronic fatigue syndrome.
Self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder (untreated), bipolar disorder, schizophrenia.
Male.