Breast Cancer Clinical Trial
Doxorubicin and Docetaxel in Treating Women With Stage III Breast Cancer
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of doxorubicin and docetaxel in treating women who have stage III breast cancer.
Full Description
OBJECTIVES:
Evaluate the clinical and pathological response rate of sequential doxorubicin and docetaxel chemotherapy in the neoadjuvant treatment of women with stage III breast cancer.
Measure signal transducer and activator of transcription (STAT) activation before and after this neoadjuvant chemotherapy regimen in this patient population.
Correlate response to chemotherapy with STAT activation before and after this neoadjuvant chemotherapy regimen in these patients.
Determine how other potential predictors of response correlate with STAT activation by measuring Bcl-2, Bcl-xL, Bax protein levels, tyrosine kinase levels, growth rate of the tumor, and apoptotic index before and after this neoadjuvant chemotherapy regimen in these patients.
Correlate response to chemotherapy with levels of STAT activation in association with the presence of Bcl-2 proteins and tyrosine kinases, growth rate of the tumor, and apoptotic index in these patients.
Evaluate the toxicity of this neoadjuvant chemotherapy regimen given in a dose-dense fashion in these patients.
OUTLINE: Patients receive doxorubicin IV on day 1 every 2 weeks for 3 courses. After 3 weeks of rest, patients receive docetaxel IV over 1 hour on day 1 every 2 weeks for 3 courses. Filgrastim (G-CSF) is administered subcutaneously on days 3-10 of each doxorubicin and docetaxel course. Within 6 weeks of completion of neoadjuvant chemotherapy, patients undergo surgery with mastectomy or lumpectomy and axillary lymph node dissection.
PROJECTED ACCRUAL: A total of 45 patients will be accrued for this study within 5 years.
Eligibility Criteria
DISEASE CHARACTERISTICS:
Histologically or pathologically confirmed stage III breast cancer
Clinical evidence of primary invasive breast tumor greater than 5 cm in dimension (T3) and no evidence of metastatic disease clinically or by staging studies including computed tomography (CT) scan of the chest, abdomen, and pelvis, and a bone scan
Inflammatory breast carcinoma defined as diffuse brawny induration of the skin of the breast with an erysipeloid edge due to embolization of the dermal lymphatics and pathologic evidence of dermal lymphatic invasion
No bilateral breast cancer unless synchronous
Hormone receptor status:
Not specified
PATIENT CHARACTERISTICS:
Age:
18 to 70
Sex:
Female
Menopausal status:
Not specified
Performance status:
Eastern Cooperative Oncology Group (ECOG) 0-1
Life expectancy:
Not specified
Hematopoietic:
WBC at least 3,000/mm^3
Absolute neutrophil count at least 1,000/mm^3
Platelet count at least 100,000/mm^3
Hepatic:
Bilirubin less than 2.0 mg/dL
SGOT/SGPT less than 1.5 times upper limit of normal (ULN)
Alkaline phosphatase no greater than 4 times ULN provided SGOT/SGPT no greater than ULN
Renal:
Creatinine no greater than 1.5 mg/dL
Cardiovascular:
If prior cardiac event or ischemia on electrocardiogram, must be cleared by cardiologist
LVEF at least 50% by resting MUGA
No severe cardiac dysfunction
No prior or concurrent angina pectoris, congestive heart failure, or major ventricular arrhythmias
No uncontrolled essential hypertension
Other:
Not pregnant or nursing
Fertile patients must use effective nonhormonal barrier contraception
No other prior malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or intraductal or lobular carcinoma in situ of the breast
No other serious medical or psychiatric illness that would preclude study consent or treatment
No prior severe and intolerable reactions to filgrastim (G-CSF)
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Not specified
Chemotherapy:
No prior chemotherapy
Endocrine therapy:
Not specified
Radiotherapy:
No prior radiotherapy to the breast
Surgery:
Not specified
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There is 1 Location for this study
Tampa Florida, 33612, United States
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