Enzastaurin For Breast Cancer Patients Who Previously Received an Anthracycline and a Taxane Chemotherapy

Inclusion Criteria:

Clinical diagnosis of metastatic breast cancer or recurrent breast cancer where surgery can not be done for curative intent
Have received prior therapy with an anthracycline (class of drugs) and a taxane (class of drugs).
Tumors must not be positive for HER2, but if positive, the treatment plan should not include further treatment with the drug Herceptin.
Disease that can be definitely measured on Cat Scans or other radiological tests.
May have received high dose chemotherapy for autologous stem cell support greater than or equal to 6 months of starting this study.

Exclusion Criteria:

More than 2 chemotherapy regimens for metastatic or locally recurrent disease.
Have brain cancer from breast cancer
Pregnant or breastfeeding
Have an inability to swallow tablets
Within 6 months have had a serious heart condition