Exercise Effect on Chemotherapy-Induced Neuropathic Pain

Inclusion Criteria:

Diagnosis with cancer, stage I-IV
History of treatment with oxaliplatin, docetaxel, or paclitaxel, either alone or in combination with other agents
Completion of chemotherapy > 6 months < 1 year
Ability to walk on a treadmill
Medical clearance from oncologist or primary care provider
Presence of CIPN per National Cancer Institute Common Toxicity Criteria grade 1-3 (0-no signs/symptoms, 1-minor loss of function, 2-increased symptoms not interfering with activities of daily living (ADLs), 3-severe symptoms interfering with ADL, 4-disabling, and 5 is death)
Score on Neuropathic Pain Scale >1
Age 21-70

Exclusion Criteria:

Denial of CIPN
Other motor/sensory neuropathy caused by other than chemotherapy (i.e.alcohol-related, autoimmune diseases, diabetes)
Coronary artery disease
History of >1 chemotherapy regimen
Musculoskeletal conditions which preclude participation in an exercise training program
Pregnancy
Regular exerciser, defined as >90 minutes per week of aerobic exercise and any resistive training