Breast Cancer Clinical Trial

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Exercise Treatment With Standard Therapy for Metastatic Breast Cancer

Summary

This study will test any good and bad effects of aerobic exercise performed while you are receiving the usual first-line treatment for metastatic breast cancer. The researchers think that exercise helps delay the development of resistance to hormone therapy while slowing the growth of tumors.

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Eligibility Criteria

Inclusion Criteria:

Patients with histologically-confirmed, HR-positive (ER and/or PR), HER2-negative metastatic breast cancer (MBC)
Postmenopausal status defined by lack of menses for 2 years, oophorectomy, or medical ovarian suppression
Receiving first line endocrine-based therapy (tamoxifen, aromatase inhibitor, or fulvestrant; concurrent molecular therapy also allowed)
Sedentary (i.e., <60 minutes / week of exercise)
Age >18 years
BMI â‰¥ 18.5
Cleared for exercise participation as per screening clearance via PAR-Q+
Cleared for study participation as per screening consultation with an MSK Exercise Physiologist
Willingness to comply with all study-related procedures
Patients with "treated and stable" brain lesions of a duration of â‰¥ 2 months may be enrolled

Exclusion Criteria:

Life expectancy <6 months
Enrollment onto any other therapeutic investigational study
Mental impairment leading to inability to cooperate
Concurrent participation in weight loss or other exercise programs

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There are 8 Locations for this study

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Memoral Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge New Jersey, 07920, United States More Info