Breast Cancer Clinical Trial

Expanded Access for the Treatment of Cancers With Rearranged During Transfection (RET) Activation

Summary

Expanded access for participants with cancer with RET activation who are ineligible for an ongoing selpercatinib (also known as LOXO-292) clinical trial or have other considerations that prevent access to selpercatinib through an existing clinical trial.

The treating physician/investigator contacts Lilly when, based on their medical opinion, a patient meets the criteria for inclusion in the expanded access program.

View Full Description

Full Description

N/A for expanded access

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Diagnosis of cancer with RET activation, who are not eligible for an ongoing selpercatinib clinical trial and are medically suitable for treatment with selpercatinib
Have progressed or are intolerant to standard therapy, or no standard therapy option exists, or in the opinion of the investigator, are unlikely to derive significant clinical benefit from standard therapy
Have adequate organ function

Exclusion Criteria:

Currently enrolled in an ongoing clinical study of selpercatinib or another RET inhibitor
Clinically significant active cardiovascular disease or history of myocardial infarction within 6 months prior to study treatment; ongoing cardiomyopathy; or current prolongation of the QT interval corrected for heart rate using Fridericia's formula (QTcF) interval greater than 470 milliseconds

Study is for people with:

Breast Cancer

Study ID:

NCT03906331

Recruitment Status:

Available

Sponsor:

Loxo Oncology, Inc.

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There are 64 Locations for this study

See Locations Near You

Cancer Treatment Centers of America
Goodyear Arizona, 85338, United States More Info
Contact
623-207-3000
Ashish Sangal
Principal Investigator
Mayo Clinic of Scottsdale
Scottsdale Arizona, 85259, United States More Info
Contact
480-301-8000
Nina J Karlin
Principal Investigator
City of Hope National Medical Center
Duarte California, 91010, United States More Info
Contact
626-256-4673
Erminia Massarelli
Principal Investigator
UCLA Medical Center
Los Angeles California, 90095, United States More Info
Contact
310-794-1816
Mykola Onyshchenko
Principal Investigator
Kaiser Permanente
Oakland California, 94612, United States More Info
Jennifer Marie Suga
Principal Investigator
Irvine Medical Center
Orange California, 92868, United States More Info
Contact
714-456-8000
Viola W Zhu
Principal Investigator
Kaiser Permanente Medical Center
Sacramento California, 95814, United States More Info
Jennifer Marie Suga
Principal Investigator
University of California - San Diego
San Diego California, 92103, United States More Info
Contact
858-534-2230
Lyudmila Bazhenova
Principal Investigator
Kaiser Permanente Medical Center
San Francisco California, 94115, United States More Info
Jennifer Marie Suga
Principal Investigator
Univ of California San Francisco
San Francisco California, 94115, United States More Info
Contact
415-353-7552
Alain Algazi
Principal Investigator
Kaiser Permanente
Santa Clara California, 95051, United States More Info
Jennifer Marie Suga
Principal Investigator
Kaiser Permanente Medical Center
Vallejo California, 94589, United States More Info
Contact
510-891-3414
Jennifer Marie Suga
Principal Investigator
Memorial Cancer Institute
Hollywood Florida, 33021, United States More Info
Contact
305-243-1000
Luis Raez
Principal Investigator
Mayo Clinic in Florida
Jacksonville Florida, 32224, United States More Info
Contact
904-953-2000
Victor Bernet
Principal Investigator
Florida Hospital
Orlando Florida, 32803, United States More Info
Contact
407-303-0409
Mark A Socinski
Principal Investigator
Tallahassee Memorial Cancer Center
Tallahassee Florida, 32308, United States More Info
Contact
850-431-5360
Karen B. Russell
Principal Investigator
University Cancer and Blood Center
Athens Georgia, 30607, United States More Info
Contact
706-353-2990
Petros G Nikolinakos
Principal Investigator
Emory University
Atlanta Georgia, 30329, United States More Info
Contact
404-727-6123
Taofeek Owonikoko
Principal Investigator
University of Chicago Medicine-Comprehensive Cancer Center
Chicago Illinois, 60637, United States More Info
Contact
630-862-5757
Christine M Bestvina
Principal Investigator
Cancer Treatment Centers of America
Zion Illinois, 60099, United States More Info
Contact
847-872-6324
Eugene R Ahn
Principal Investigator
Massachusetts General Hospital
Boston Massachusetts, 02114, United States More Info
Contact
617-726-2515
Lori Wirth
Principal Investigator
Dana-Farber Cancer Institute
Boston Massachusetts, 02215, United States More Info
Contact
617-632-5869
Geoffrey Oxnard
Principal Investigator
University of Michigan
Ann Arbor Michigan, 48109, United States More Info
Contact
734-647-8902
Francis Worden
Principal Investigator
START Midwest
Grand Rapids Michigan, 49546, United States More Info
Contact
616-954-5554
Nehal Lakhani
Principal Investigator
Mayo Clinic
Rochester Minnesota, 55905, United States More Info
Contact
5072844080
John Columbus Morris
Principal Investigator
Comprehensive Cancer Centers of Nevada
Las Vegas Nevada, 89169, United States More Info
Contact
702-952-3400
Fadi S Braiteh
Principal Investigator
Memorial Sloan Kettering Cancer Center
New York New York, 10065, United States More Info
Contact
646-888-4206
Alexander Drilon
Principal Investigator
Cleveland Clinic Foundation
Cleveland Ohio, 44195, United States More Info
Contact
216-444-1128
Nathan Pennell
Principal Investigator
Ohio State University Medical Center
Columbus Ohio, 43210, United States More Info
Contact
614-293-3873
Manisha H Shah
Principal Investigator
Cancer Treatment Centers of America
Tulsa Oklahoma, 74133, United States More Info
Contact
918-286-5689
Issam Alawin
Principal Investigator
University of Pennsylvania Hospital
Philadelphia Pennsylvania, 19104, United States More Info
Contact
215-898-8796
Marcia Brose
Principal Investigator
Eastern Regional Medical Center
Philadelphia Pennsylvania, 19124, United States More Info
Contact
215-537-4555
Arturo Loaiza-Bonilla
Principal Investigator
Oncology Consultants
Houston Texas, 77030, United States More Info
Contact
713-797-6323
Julio A. Peguero
Principal Investigator
University of Texas MD Anderson Cancer Center
Houston Texas, 77030, United States More Info
Contact
713-745-6754
Vivek Subbiah
Principal Investigator
Virginia Cancer Specialists
Fairfax Virginia, 22031, United States More Info
Contact
703-280-5390
Alexander I Spira
Principal Investigator
University of Wisconsin-Madison Hospital and Health Clinic
Madison Wisconsin, 53792, United States More Info
Mark Burkard
Principal Investigator
NSW Health - Sydney Local Health District
Camperdown New South Wales, 2050, Australia More Info
Contact
610295156111
Michael Boyer
Principal Investigator
Royal North Shore Hospital
St. Leonards New South Wales, 2065, Australia More Info
Bruce Robinson
Principal Investigator
Queensland Health - Metro North Hospital and Health Service
Chermside Queensland, 4032, Australia More Info
Contact
0731394000
Brett Hughes
Principal Investigator
Peter MacCallum Cancer Centre
Melbourne Victoria, 3000, Australia More Info
Benjamin Solomon
Principal Investigator
Linear Clinical Research
Nedlands Western Australia, 6009, Australia More Info
Contact
611300546327
Samantha Bowyer
Principal Investigator
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
Bordeaux Aquitaine, 33076, France More Info
Contact
33556333244
Antoine Italiano
Principal Investigator
AP-HM
Marseille , 13005, France More Info
Contact
33 0491385416
Pascale Tomasini
Principal Investigator
Gustave Roussy
Villejuif Cedex , 94805, France More Info
Benjamin Besse
Principal Investigator
Universitätsklinikum Würzburg A. ö. R.
Würzburg Bayern, 97080, Germany More Info
Matthias Kroiss
Principal Investigator
Universitätsklinikum Köln
Köln Nordrhein-Westfalen, 50937, Germany More Info
Contact
492214783993
Jürgen Wolf
Principal Investigator
Charité Campus Virchow-Klinikum
Berlin , 13353, Germany More Info
Contact
493045050
Damian Tobias Rieke
Principal Investigator
Prince of Wales Hospital
Hong Kong Shatin, New Territories, , Hong Kong More Info
Contact
85226322648
Herbert Ho Fung Loong
Principal Investigator
Sheba Medical Center
Ramat Gan HaMerkaz, 52621, Israel More Info
Contact
97235302754
Talia Golan
Principal Investigator
Shaare Zedek Medical Center
Jerusalem Yerushalayim, 91031, Israel More Info
Nir Peled
Principal Investigator
Soroka Medical Center - Pediatric Outpatient Clinic
Beer-Sheva , 84101, Israel More Info
Julia Dudnik
Principal Investigator
Istituto Nazionale dei Tumori
Milano Lombardie, 20133, Italy More Info
Filippo De Braud
Principal Investigator
Azienda Ospedaliero Universitaria Pisana
Pisa PI, 56124, Italy More Info
Contact
390502212111
Rossella Elisei
Principal Investigator
ASST Grande Ospedale Metropolitano Niguarda Comitato Etico Milano Area C
Milano , 20162, Italy More Info
Contact
390264442464
Salvatore Siena
Principal Investigator
National Cancer Center Hospital East
Kashiwa Chiba, 277-8, Japan More Info
Contact
81471331111
Koichi Goto
Principal Investigator
Hokkaido University Hospital
Sapporo Hokkaido, 060-8, Japan More Info
Jun Sakakibara
Principal Investigator
Kanazawa University Hospital
Kanazawa Ishikawa, 920-8, Japan More Info
Contact
81762652000
Shinji Takeuchi
Principal Investigator
National Cancer Center Hospital
Chuo-ku Tokyo, 104-0, Japan More Info
Contact
81335422511
YUICHIRO OHE
Principal Investigator
Tottori University Hospital
Yonago Tottori, 683-8, Japan More Info
Contact
81859331111
Tomohiro Sakamoto
Principal Investigator
Osaka City General Hospital
Osaka , 534-0, Japan More Info
Contact
81669291221
Haruko Daga
Principal Investigator
University of Auckland
Auckland , 91346, New Zealand More Info
Contact
6493737999
Mark McKeage
Principal Investigator
Uniwersyteckie Centrum Kliniczne
Gdansk , 80-95, Poland More Info
Contact
0583492270
RAFAL DZIADZIUSZKO
Principal Investigator
Centrum Onkologii Instytut im Marii Curie w Warszawie
Warszawa , 02-03, Poland More Info
Contact
0048225463380
Iwona Lugowska
Principal Investigator
National Cancer Centre Singapore
Singapore Central Singapore, 16961, Singapore More Info
Contact
654368000
Shao Weng Daniel Tan
Principal Investigator
Hospital Universitari Vall d'Hebron
Barcelona Barcelona [Barcelona], 8035, Spain More Info
Contact
934893000
Elena Garralda Cabanas
Principal Investigator
Hospital Madrid Norte Sanchinarro
Madrid , 28050, Spain More Info
Maria Jose Miguel Luken
Principal Investigator
Kantonsspital Luzern
Luzern 16 Luzern, 6000, Switzerland More Info
Contact
412051111
Oliver Gautschi
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Study ID:

NCT03906331

Recruitment Status:

Available

Sponsor:


Loxo Oncology, Inc.

How clear is this clinincal trial information?

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