HER-2 Pulsed DC Vaccine to Prevent Recurrence of Invasive Breast Cancer Post Neoadjuvant Chemotherapy

Inclusion Criteria:

Women ≥ 18 years.
HER-2 expressing stage I - III breast cancer with residual disease in the breast or axillary nodes post-neoadjuvant chemotherapy.
Women of childbearing age with a negative pregnancy serum test documented prior to enrollment.
Eastern Cooperative Oncology Group (ECOG) Performance Status Score of 0 or 1.
Women of childbearing potential must agree to use a medically acceptable form of birth control during their participation in the study.
Have voluntarily signed a written Informed Consent in accordance with institutional policies after its contents have been fully explained to them.

Exclusion Criteria:

Pregnant or lactating.
Positive for HIV or hepatitis C at baseline by self report.
Potential participants with coagulopathies, including thrombocytopenia with platelet count <75,000, INR > 1.5 and partial thromboplastin time > 50 sec.
Potential participants with MUGA < 50% EF.
Pre-existing medical illnesses or medications which might interfere with the study as determined by Principal Investigator (PI).