Koning Breast Computed Tomography Guided Neoadjuvant Treatment Monitoring

Inclusion Criteria:

Female gender
Age 18 years or older
Any ethnicity
Are undergoing neoadjuvant therapy for locally advanced breast cancer with either chemotherapy or hormonal therapy
Is able to provide informed consent.

Exclusion Criteria:

Pregnancy
Lactation
Women who are unable or unwilling to understand or to provide informed consent
Women with physical limitations that may prohibit resting prone on the exam table, such as, but not limited to: frozen shoulder, recent heart surgery, pace maker.
Women who are unable to tolerate study constraints.
Women who have received radiation treatments to the thorax for malignant and nonmalignant conditions, such as (but not limited to):
Treatment for enlarged thymus gland as an infant
Irradiation for benign breast conditions, including breast inflammation after giving birth
Treatment for Hodgkin's disease
Women who have participated in a prior breast clinical trial that gave additional radiation dose, such as an additional mammogram.
Women who have received large numbers of diagnostic x-ray examinations for monitoring of disease such as (but not limited to):
Tuberculosis
Severe scoliosis