Breast Cancer Clinical Trial

Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Breast Cancer

Summary

This is an observational study for patients with breast cancer that will be treated with doxorubicin (Adriamycin) and/or trastuzumab (Herceptin). The study will help the investigators learn more about how these medications affect the heart and how those effects relate to patients' medical history and social determinants of health (such as race, gender identity, education, occupation, access to health services and economic resources). Patients on this study will have echocardiograms, blood draws, and answer questions about their symptoms and activity level. Patients will be followed on this study for up to 15 years.

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Full Description

The investigators propose a prospective longitudinal cohort of breast cancer patients treated with anthracyclines and/or trastuzumab to determine the associations between social determinants of health (SDOH) and cardiotoxicity risk and to determine whether associations between SDOH and cardiotoxicity risk differ according to race. Patients will be followed with serial echo, blood draw, and surveys every 3 months for the first year, then annually for two years. After 3 years following start of cancer therapy, patients will have study visits every other year for up to 15 years.

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Eligibility Criteria

Inclusion Criteria:

Women older than 18 years of age
Breast cancer with treatment plan that includes doxorubicin and/or trastuzumab
Ability to provide written informed consent

Exclusion Criteria:

Pregnancy at enrollment
Inability or unwillingness to provide consent

Study is for people with:

Breast Cancer

Estimated Enrollment:

200

Study ID:

NCT05078190

Recruitment Status:

Recruiting

Sponsor:

Abramson Cancer Center of the University of Pennsylvania

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There is 1 Location for this study

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University of Pennsylvania
Philadelphia Pennsylvania, 19104, United States

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Estimated Enrollment:

200

Study ID:

NCT05078190

Recruitment Status:

Recruiting

Sponsor:


Abramson Cancer Center of the University of Pennsylvania

How clear is this clinincal trial information?

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