PET/MR in Surgical Planning for Breast CA Treated With Neoadj Chemo

Inclusion Criteria:

Age ≥ 18 years of age (no upper age limit)
Signed, IRB-approved written informed consent
Must have clinical T1-3, N0-3, M0 disease. All phenotypes are acceptable..
Must have surgically curable disease as evaluated by the UNC Multidisciplinary Tumor Board.
Must have pre- and post-treatment MRI imaging as part of the treatment plan.
Must be able to meet size restrictions for the PET-MR scanner: chest depth and abdominal depth less than 27 cm (approximately the smallest 55% of women will meet this), as measured on imaging or with physical template.
Must be in acceptable health to undergo chemotherapy and curative intent surgery as assessed by Multidisciplinary Tumor Board.
Must be able to understand and comply with study procedures for the entire length of the study.
Must receive their chemotherapy and curative intent surgery at UNC Hospitals. -If patient has a history of prior malignancy, including melanoma, patient must be cancer- free for three or more years. Non-melanoma skin cancers will be included even if not cancer-free for three years.
Women of childbearing potential must have a negative serum or urine pregnancy test performed within 7 days prior to each PET/MRI

Exclusion Criteria:

Inability to tolerate MRI (e.g., inability to lie flat for >1 hour)
Presence of pacemaker, intracranial aneurysm clip, bladder stimulator, cochlear implant or metal near eyes or near pelvis that would create excessive imaging artifact
Poorly controlled diabetes mellitus
Patient receiving neoadjuvant endocrine therapy (due to low likelihood of complete response)
Pregnancy or lactating female
Substance abuse, medical, psychological, or social conditions that may interfere with the patient's participation in the study
Evidence of distant disease on physical exam or initial imaging
Medical conditions precluding chemotherapy or curative intent surgery
Incarcerated or otherwise institutionalized at time of enrollment