Breast Cancer Clinical Trial
Prospective Randomized Study of Accelerated Radiation Therapy (PRART)
Patients with Stage 0 ductal carcinoma in situ (Tis (DCIS), Stage T1-T2, lymph node negative(N0) breast cancers will be randomized to receive whole breast radiotherapy with a concomitant boost to the tumor bed over 15 fractions (Arm 1, standard) versus 10 fractions (Arm 2, experimental).
Women status post segmental mastectomy
If unilateral, pT1-2 breast cancer excised with negative margins
If bilateral, pT1-2 breast cancer excised with negative margins AND/OR pTis excised with negative margins.
Clinically N0 or pN0 or sentinel node negative
Ductal carcinoma in situ DCIS with negative margins (no DCIS on inked margins).
Previous radiation therapy to the ipsilateral breast.
90 days from last surgery, unless s/p adjuvant chemotherapy
60 days from last chemotherapy
Male breast cancer
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