Breast Cancer Clinical Trial

RPFNA Assessment of Exercise Effect in Breast Cancer

Summary

This study is being done to see if the investigators can measure changes that occur in breast tissue when women at risk of developing breast cancer start an exercise program. The investigators are interested in studying this because research shows that women who exercise regularly are less likely to develop breast cancer, but there is not very much information explaining how exercise could affect breast cells in a way to prevent cancer from occurring. In this research study the investigators will use a research technique called breast random fine needle aspiration (RPFNA) to test breast cells for their shape and how they look. The investigators will look at breast cells before and after a participant takes part in an exercise program to see if the investigators are able to see any changes in breast cells that could have happened due to the exercise program. This research will help us to develop larger projects to see if exercise programs could be helpful in preventing breast cancer.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

History of lobular carcinoma in situ, atypical ductal/lobular hyperplasia on prior breast biopsy or lifetime risk of breast cancer of at least 20% based on any risk model, or personal history of BRCA1 or 2 mutation
Physically able to exercise and physician consent to start an exercise program
Sedentary activity pattern
Premenopausal
English speaking and able to read English

Exclusion Criteria:

History of invasive breast cancer or ductal carcinoma in situ
Absolute contraindications to maximal exercise testing as recommended by the American Thoracic Society
Any condition which in the investigator's opinion makes the subject unsuitable for study participation
Participating in another clinical study with competing study outcomes
Pregnant or breastfeeding
Unable to comply with protocol and/or not available for follow-ups
Type II Diabetes
Allergic to local anesthetics
History of bilateral or unilateral mastectomy

Study is for people with:

Breast Cancer

Estimated Enrollment:

2

Study ID:

NCT01961128

Recruitment Status:

Completed

Sponsor:

Dana-Farber Cancer Institute

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There is 1 Location for this study

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Dana-Farber Cancer Institute
Boston Massachusetts, 02215, United States

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Estimated Enrollment:

2

Study ID:

NCT01961128

Recruitment Status:

Completed

Sponsor:


Dana-Farber Cancer Institute

How clear is this clinincal trial information?

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