Sitravatinib in Metastatic Breast Cancer

Inclusion Criteria:

Women or men age 18 and older
Metastatic or locally advanced inoperable disease breast cancer
Tumor is estrogen receptor (ER) negative and progesterone receptor (PR) negative per the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) Guidelines of 2010.
Tumor is HER2neu negative per ASCO/CAP Guidelines of 2018
Patient has tumor tissue blocks from metastatic or locally advanced breast cancer (beyond curative management) for the analysis of PTPN12 status
Metastatic disease or locally advanced breast cancer (beyond curative management) that is measurable according to RECIST 1.1 criteria. Patients with bone only disease are eligible for enrollment if there is at least one lytic lesion that can be followed for response.
At least one prior line of chemotherapy with or without a PDL1 or PD1 antibody in metastatic setting
Patient has Eastern Cooperative Oncology Group (ECOG) performance status <2 (Karnofsky > 60%)

Patients must have normal organ and marrow function as defined below:

Absolute neutrophil count > 1000/mcL
Hemoglobin > 11 g/dL
Platelets >100,000/mcL
Total bilirubin < 1.5 X normal institutional limits
Aspartate aminotransferase (AST) / alanine aminotransferase (ALT) < 2.5 X institutional upper limit of normal (ULN) or ≤ 5.0 × ULN for patients with documented liver metastases.
Creatinine within normal institutional limits
Creatinine clearance > 30 mL/min/1.73 m2
Normal left ventricular ejection (LVEF) function defined as normal left ventricular wall motion and ejection fraction of ≥ 50%.
If patient has brain metastasis, documented treatment and stability for at least 30 days by scans and off steroids at the time of enrollment
Women of child bearing age and actively menstruating must have a negative pregnancy test prior to study enrollment.
Ability to understand and the willingness to give informed consent

Exclusion Criteria:

Untreated hypertension defined as systolic blood pressure > 140 and/or diastolic blood pressure > 90 on two or more occasions within the past 30 days previous to enrollment
Imaging suggestive of Lymphangitic carcinomatosis in the lung, or use of home oxygen
Untreated brain metastases.
Pregnancy or lactation at time of trial enrollment
Concomitant metastatic disease of another tumor type
Patient has impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of the study drugs
History of stroke, pulmonary embolus (PE), or myocardial infarction (MI) at any time
Known Proteinuria of ≥ 2 g/24 h
HIV-positive participants.
History of Hepatitis C and Hepatitis B infection
Documented history of congestive heart failure, and/or LVEF less than 50%
Concurrent use of medications on the prohibited medications list, unless these medications can be replaced by alternatives. These medications need to be discontinued at least 2 weeks prior to enrollment.
Presence of other medical condition that, in the sole judgment of the principal investigator, makes the patient not a good candidate.