Breast Cancer Clinical Trial

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

Summary

This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors.

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Full Description

This study is a Phase I/IIa modular, open-label, multi-center study of AZD5305 administered orally, either as monotherapy or in combination with other anti-cancer agents in patients with advanced solid malignancies.

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Eligibility Criteria

Key Inclusion Criteria:

Age ≥ 18 at the time of screening
Histological or cytological confirmation of advanced malignancy considered to be suitable for study treatment and meeting module specific eligibility criteria..
Eastern Cooperative Oncology Group Performance status (ECOG PS: 0-2)
Life expectancy ≥ 12 weeks
Progressive cancer at the time of study entry
Patients must have evaluable disease as defined in module-specific criteria for Part A and Part B
Adequate organ and marrow function as defined by the protocol.
For Part B expansion cohorts: Provision of formalin-fixed and paraffin embedded (FFPE) tumour specimen is mandatory, where available, except if stated that it is optional in a specific Module.

For Part A:

- Patients may have received up to one prior line of therapy with a PARPi-based regimen (either as a treatment or as maintenance)

For Part B:

- Patients must not have received prior therapy with a PARPi-based regimen (either as a treatment or as maintenance).

Key Exclusion Criteria:

Treatment with any of the following:

Nitrosourea or mitomycin C within 6 weeks of the first dose of study treatment
Any investigational agents or study drugs from a previous clinical study within 5 half-lives or 3 weeks (whichever is shorter) of the first dose of study treatment
Any other chemotherapy, immunotherapy or anticancer agents within 3 weeks of the first dose of study treatment
Any live virus or bacterial vaccine within 28 days of the first dose of study treatment
Concomitant use of medications or herbal supplements known to be cytochrome P450 3A4 (CYP3A4) strong and moderate inhibitors or inducers.
Concomitant use of drugs that are known to prolong or shorten QT and have a known risk of Torsades de Pointes.
Receiving continuous corticosteroids at a dose of >10 mg prednisone/day or equivalent for any reason.
Major surgery within 4 weeks of the first dose of study treatment.
Radiotherapy with a wide field of radiation within 4 weeks or radiotherapy with a limited field of radiation for palliation within 2 weeks of the first dose of study treatment.
Any history of persisting (> 2 weeks) severe pancytopenia due to any cause
Spinal cord compression or brain metastases unless asymptomatic, treated and stable and not requiring continuous corticosteroids at a dose of >10mg prednisone/day or equivalent for at least 4 weeks prior to start of study treatment. Patients with leptomeningeal carcinomatosis are excluded.
Cardiac conditions as defined by the clinical study protocol

Other cardiovascular diseases as defined by any of the following:

Symptomatic heart failure,
uncontrolled hypertension,
hypertensive heart disease with significant left ventricular hypertrophy
acute coronary syndrome (ACS)/acute myocardial infarction (AMI), unstable angina pectoris, coronary intervention procedure with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) within 6 months.
cardiomyopathy of any etiology
presence of clinically significant valvular heart disease
history of atrial or ventricular arrhythmia requiring treatment; subjects with atrial fibrillation and optimally controlled ventricular rate (< 100 beats per minute) are permitted.
subjects with atrial fibrillation and optimally controlled ventricular rate are permitted
transient ischaemic attack, or stroke within 6 months prior to screening
patients with symptomatic hypotension at screening
Patients with myelodysplastic syndrome/acute myeloid leukaemia or with features suggestive of myelodysplastic syndrome (MDS)/acute myeloid leukaemia (AML).
Refractory nausea and vomiting, chronic gastrointestinal diseases, inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption of AZD5305
Known allergy or hypersensitivity to investigational product(s) or any of the excipients of the investigational product(s).

other module-specific criteria may apply

Study is for people with:

Breast Cancer

Phase:

Phase 1

Estimated Enrollment:

715

Study ID:

NCT04644068

Recruitment Status:

Recruiting

Sponsor:

AstraZeneca

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There are 53 Locations for this study

See Locations Near You

Research Site
San Francisco California, 94143, United States
Research Site
New York New York, 10021, United States
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Oklahoma City Oklahoma, 73104, United States
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Houston Texas, 77030, United States
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Melbourne , 3000, Australia
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Kelowna British Columbia, V1Y 5, Canada
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Vancouver British Columbia, V5Z 1, Canada
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London Ontario, N6A 4, Canada
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Toronto Ontario, M4N 3, Canada
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Toronto Ontario, M5G 2, Canada
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Montreal Quebec, H2X 0, Canada
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Montreal Quebec, H3T 1, Canada
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Quebec , G1R 2, Canada
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Changsha , 41001, China
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Chengdu , 61004, China
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Chongqing , 40003, China
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Guangzhou , 51006, China
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Shanghai , 20003, China
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Brno , 656 5, Czechia
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Budapest , 1062, Hungary
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Budapest , 1083, Hungary
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Budapest , 1122, Hungary
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Milano , 20132, Italy
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Milan , 20141, Italy
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Modena , 41125, Italy
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Napoli , 80131, Italy
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Padova , 35128, Italy
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Roma , 00168, Italy
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Chuo-ku , 104-0, Japan
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Koto-ku , 135-8, Japan
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Seoul , 03080, Korea, Republic of
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Seoul , 03722, Korea, Republic of
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Seoul , 05505, Korea, Republic of
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Seoul , 06351, Korea, Republic of
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Bydgoszcz , 85-79, Poland
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Gdynia , 81-51, Poland
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Grzepnica , 72-00, Poland
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Lublin , 20-09, Poland
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Toruń , 87-10, Poland
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Warszawa , 02-78, Poland
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Moscow , 11112, Russian Federation
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Moscow , 11547, Russian Federation
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Moscow , 11799, Russian Federation
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Moscow , 14344, Russian Federation
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Barcelona , 08035, Spain
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Madrid , 28041, Spain
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Madrid , 28050, Spain
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Málaga , 29010, Spain
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Sevilla , 41013, Spain
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Cambridge , CB2 0, United Kingdom
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Manchester , M20 4, United Kingdom
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Oxford , OX3 7, United Kingdom
Research Site
Sutton , SM2 5, United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Phase:

Phase 1

Estimated Enrollment:

715

Study ID:

NCT04644068

Recruitment Status:

Recruiting

Sponsor:


AstraZeneca

How clear is this clinincal trial information?

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