Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options

Inclusion Criteria:

Disease status:

Phase 1 portion (closed): Participants must have measurable or evaluable disease, as defined by RECIST v1.1

Phase 2 portion:

Part B: Participants must have measurable or evaluable disease, as defined by RANO
Part C (closed): Participants must have measurable or evaluable disease, as defined by RECIST v1.1 ± Curie Scale
Part D: Participants must have measurable or evaluable disease, as defined by RECIST v1.1
Part E (closed): Participants must have measurable or evaluable disease, as defined by RECIST v1.1 ± Curie Scale or RANO

Tumor type:

Phase 1 portion:

* Part A: Relapsed or refractory extracranial solid tumors

Phase 2 portion

Part B: Primary brain tumors with NTRK1/2/3 or ROS1 gene fusions; gene fusions are defined as those predicted to translate into a fusion protein with a functional TRKA/B/C or ROS1 kinase domain, without a concomitant second oncodriver as determined by a nucleic acid-based diagnostic testing method
Part D: Extracranial solid tumors (including NB) with NTRK1/2/3 or ROS1 gene fusions; gene fusions are defined as those predicted to translate into a fusion protein with a functional TRKA/B/C or ROS1 kinase domain, without a concomitant second oncodriver as determined by a nucleic acid-based diagnostic testing method
Histologic/molecular diagnosis of malignancy at diagnosis or the time of relapse
Archival tumor tissue from diagnosis or, preferably, at relapse
Performance status: Lansky or Karnofsky score ≥ 60% and minimum life expectancy of at least 4 weeks
Prior therapy: Participants must have a disease that is locally advanced, metastatic, or where surgical resection is likely to result in severe morbidity, and who have no satisfactory treatment options for solid tumors and primary CNS tumors that are neurotrophic tyrosine receptor kinase (NTRK) or ROS1 fusion-positive
Participants must have recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to enrollment
Adequate organ and neurologic function
Females of childbearing potential must have a negative serum pregnancy test during screening and be neither breastfeeding nor intending to become pregnant during study participation. Agreement to remain abstinent or use use combined contraceptive methods prior to study entry, for the duration of study participation and in the following 90 days after discontinuation of study treatment.
For male participants with a female partner of childbearing potential or a pregnant female partner: Agreement to remain abstinent or use a condom during the treatment period and for at least 3 months after the last dose of study drug

Exclusion Criteria:

Receiving other experimental therapy
Known congenital long QT syndrome
History of recent (3 months) symptomatic congestive heart failure or ejection fraction ≤50% at screening
Known active infections
Familial or personal history of congenital bone disorders, bone metabolism alterations or osteopenia
Receiving Enzyme Inducing Antiepileptic Drugs (EIAEDs) within 14 days of first dose.
Prior treatment with approved or investigational TRK or ROS1 inhibitors
Known hypersensitivity to entrectinib or any of the other excipients of the investigational medicinal product
Patients with NB with bone marrow space-only disease
Incomplete recovery from acute effects of any surgery prior to treatment.
Active gastrointestinal disease or other malabsorption syndromes that would impact drug absorption.
Other severe acute or chronic medical or psychiatric condition or lab abnormality that may increase the risk associated with study participation, drug administration or may interfere with the interpretation of study results.