Breast Cancer Clinical Trial

Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas

Summary

This is a Phase 1/2a open-label, multicenter, dose escalation and dose expansion trial in which IMT-009 will be administered by the intravenous (IV) route to participants with solid tumors or lymphomas.

The main goals of this study are to:

Find the recommended dose of IMT-009 that can be safely given to participants
Learn more about the side effects of IMT-009
Learn more about pharmacokinetics of IMT-009
Learn more about the effectiveness of IMT-009
Learn more about different pharmacokinetic biomarkers and how they might change in the presence of IMT-009

View Full Description

Full Description

IMT-009 is an Fc-attenuated monoclonal antibody that binds with high affinity and selectivity to CD161, a receptor that is broadly expressed on NK and a subset of memory T cells, blocking interactions between the receptor and its cognate ligand, CLEC2D, which is expressed on the surface of both cancer cells and immune cells. Preclinical data confirm that CD161 blockade with IMT-009 results in enhanced anti-tumor activity. This is a Phase 1/2a, open label dose escalation study of IMT-009, a fully human monoclonal antibody targeting CD161, given as a single agent in Phase 1 and potentially in combination with other antineoplastic agents in Phase 2.

View Eligibility Criteria

Eligibility Criteria

Key Inclusion Criteria:

Phase 1:

Males and females ≥18 years of age at the time of consent

Patients who have histologically or cytologically-documented, unresectable locally advanced, or metastatic solid malignancy or designated lymphoma that is progressing or has failed the therapies listed below or who are intolerant of or are ineligible for or refuse standard of care therapy as detailed below.

Patients previously pre-treated with a checkpoint inhibitor must be anti-PD-L1 relapsed/refractory defined as having clear evidence of radiologic or clinical progression while on or within 4 months of their last anti-PD-L1 dose.
There is no limit to the number of prior treatment regimens a patient may have had prior to enrollment.

Has one of the following solid tumor or lymphoma indications:

Non-small cell lung cancer (NSCLC) - squamous or non-squamous:

Must have received prior chemotherapy and a checkpoint inhibitor (either sequentially or in combination) per PD-L1 status
Must not have a documented EGFR, ALK, ROS, RET, BRAFV600E, Met exon 14 skipping, KRAS mutation

Head and neck squamous cell carcinoma (HNSCC) HPV+ or -:

Must have received prior treatment with a platinum-based chemotherapy and a checkpoint inhibitor (either sequentially or in combination) per PD-L1 status

Triple negative breast cancer (TNBC):

Must have received prior treatment with chemotherapy (anthracycline, and/or taxanes, and/or platinum, and/or gemcitabine); sacituzumab govitecan; a checkpoint inhibitor if PD-L1+; a PARPi for patients with gBRCA mutations

Cutaneous squamous cell carcinoma:

Must have received prior treatment with a checkpoint inhibitor

Hormone receptor positive (HR+) breast cancer:

- Must have received endocrine therapy, a CDK 4/6 inhibitor (preferably in combination with endocrine therapy in the 1st line or 2nd line setting or as monotherapy), a PI3K inhibitor and endocrine therapy for tumors with PIK3CA activating mutation; and a PARPi for patients with gBRCA mutations

Small bowel carcinoma:

Must have received prior treatment with at least one 5FU or capecitabine based regimen (such as but not limited to FOLFOX, FOLFIRI or CAPOX) with or without bevacizumab, and a PD1/PD-L1 inhibitor alone or in combination with CTLA4 inhibitor (for MSI-H or dMMR tumors)

Esophageal cancer:

Must have received prior treatment with a platinum-based chemotherapy and a checkpoint inhibitor (either sequentially or in combination per PD-L1 status), and an anti-HER2 agent for patients with known HER2 overexpressing tumors

Colorectal cancer (MSS & MSI-H/dMMR):

Must have received at least one 5FU chemotherapy-based regimen, with bevacizumab or cetuximab/panitumumab, and / or a PD1/PD-L1 (single agent or combination with CTLA4) for dMMR/MSI-H tumors
For patients with known BRAF V600E mutation: must have received prior treatment with a combination of encorafenib and cetuximab or panitumumab

Histologically confirmed diffuse large B cell lymphoma (DLBCL)

Must have received at least 2 prior lines of therapy including prior treatment with chemotherapy and an anti-CD20 antibody (ie, CHOP)
Must be ineligible or refuse therapies with demonstrated clinical benefit such as for example CAR-T or autologous stem cell transplant

Hodgkin lymphoma:

- Must have received at least 3 prior systemic therapies, including combination chemotherapy (ie, ABVD).

Burkitt lymphoma:

Must have received at least 2 prior lines of therapy
Must be ineligible or refuse therapies with demonstrated clinical benefit

Follicular lymphoma:

Must have received 3 prior lines of therapy, and must have received rituximab and chemotherapy
Patients with solid tumors have measurable disease based on RECIST 1.1. In hematological malignancies LYRIC/Lugano will be used.
In defined cohorts must have confirmed positive expression of CD161. Patients must have an available archival biopsy sample or agree to have a fresh biopsy obtained to confirm positivity and must agree to a mandatory newly obtained on-treatment biopsy.

Phase 1B:

Must meet all of eligibility criteria in Phase 1, AND the following:

Must have histologically or cytologically-documented, unresectable, locally-advanced or metastatic MSS CRC with documented IHC for MMR and/or DNA for MSI consistent with MSS CRC.
Eligible for treatment with fruquintinib according to the FDA-approved USPI
Must have received no more than 3 prior lines of therapy, consisting of prior treatment with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if RAS wild-type and medically appropriate, an anti-EGFR therapy
Body weight ≥40kg

Phase 2A:

Inclusion criteria for these patients will remain similar to those used during Phase 1.

Key Exclusion Criteria:

Phase 1:

Any prior Grade 4 immune-mediated adverse event (imAE) or Grade 3 imAE requiring steroid treatment (>10 mg/day prednisone or equivalent dose for more than 12 weeks) while receiving immunotherapy that has been documented within the 12 months prior to enrollment.
Unresolved toxicity higher than Grade 1 CTCAE v 5 (or higher) attributed to any prior therapy/procedure at screening, except for alopecia.
Prior history of serious hypersensitivity reaction to treatment with a monoclonal antibody
Patients who are currently pregnant or breastfeeding
Use of other investigational drugs (drugs not marketed for any indication) within 14 days or at least 5 half-lives (whichever is shorter) before investigational enrollment (Day 1, Cycle 1 dosing)
Patient with history of malignancy (other than the one for which he/she participates in the study or than basal cell carcinoma definitively resected, or other in situ cancers) - unless the patient has undergone curative therapy with no evidence of that disease for 3 years
Patients currently receiving cancer therapy (ie, chemotherapy, radiation therapy, immunotherapy, biologic therapy, hormonal therapy, surgery, and/or tumor embolization) or expected to require any other form of antineoplastic therapy while on study.
Patients with active, known or suspected autoimmune disease requiring systemic treatment (corticosteroids or other active immunosuppressive medications) within the past 6 months - with the exclusion of vitiligo, resolved asthma/atopia or alopecia areata; hypothyroidism stable on hormone replacement.
Known CNS metastases (unless clinically stable for at least 4weeks prior to enrollment and off steroids for at least 7 days- exceptions above for physiologic replacement doses of hydrocortisone)
Myocardial infarction, symptomatic congestive heart failure (NYHA> Class II), unstable angina, or serious uncontrolled cardiac arrhythmia within the last 6 months of screening
Patient has history of or current HIV, Hepatitis B or C infection, even if not active and/or controlled

Phase 1B:

Must not have met any exclusion criteria for Phase 1, and must not have any of the following:

Serum electrolytes, potassium, calcium, or magnesium levels outside of the normal laboratory reference range and clinically significant in the investigator's judgment
Serum creatinine >1.5 × ULN or creatinine clearance <60 L/min.
Urine dipstick protein ≥2+ or 24-hour urine protein ≥1.0 g/24-h
Uncontrolled hypertension, defined as: systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg despite optimal medical management
History of thromboembolic events
Clinically significant cardiovascular disease, including but not limited to acute myocardial infarction or coronary artery bypass surgery, symptomatic congestive heart failure (New York Heart Association [NYHA] Classification > Class II), severe or unstable angina, or serious uncontrolled cardiac arrhythmia within the last 6 months of screening
Patient has history of or current human immunodeficiency virus (HIV), or hepatitis B infection, even if not active and/or controlled. Prior hepatitis C virus (HCV) infection treated with a full course of curative intent antivirals with an undetectable viral load (below the lower limit of detection) are eligible
Use of strong inducers or inhibitors of CYP3A4 within 2 weeks prior to the first dose of study drug and while on study
Planned major surgery within 2 weeks prior to study start or during the study

Phase 2A:

Exclusion criteria are expected to remain the same as Phase 1 unless there is a need to further refine expansion cohort populations for Phase 2a. Patients must have a CD161 positive tumor demonstrated by the IHC CLIA assay for each analyte.

Study is for people with:

Breast Cancer

Phase:

Phase 1

Estimated Enrollment:

151

Study ID:

NCT05565417

Recruitment Status:

Recruiting

Sponsor:

Immunitas Therapeutics

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There are 10 Locations for this study

See Locations Near You

Site 9618
Tucson Arizona, 85711, United States
Site 5000
Denver Colorado, 80218, United States
Site 4100
Orlando Florida, 32827, United States
Site 4060
Sarasota Florida, 34232, United States
Site 9012
Minneapolis Minnesota, 55404, United States
Site 4500
Oklahoma City Oklahoma, 73104, United States
Site 9280
Portland Oregon, 97239, United States
Site 3000
Nashville Tennessee, 37203, United States
Site 9384
Austin Texas, 78705, United States
Site 9112
Fairfax Virginia, 22031, United States

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Phase:

Phase 1

Estimated Enrollment:

151

Study ID:

NCT05565417

Recruitment Status:

Recruiting

Sponsor:


Immunitas Therapeutics

How clear is this clinincal trial information?

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