Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia

Key Inclusion Criteria:

Documented diagnosis of non-small cell lung, pancreatic, colorectal, prostate, breast or ovarian cancer which, in the treating oncologist's assessment, is considered advanced.
Anorexia as defined by a score of ≤5 in the Cancer-Related Cachexia Symptom Assessment Appetite 7-day recall scale

Meets any of the following criteria at Randomization:

Not currently receiving antineoplastic therapy
On standard of care systemic antineoplastic therapy or treatment without curative intent
Signed informed consent.

Key Exclusion Criteria:

Receiving tube feedings or parenteral nutrition at the time of Screening or Randomization.
Current active reversible causes of decreased food intake.
Current, severe gastrointestinal disease
Participants with known symptomatic brain metastases requiring steroids.
Active uncontrolled bacterial, fungal, or viral infection, including HBV, HCV, HIV or participants with known AIDS-related illness
inadequate renal or liver function.
Women who are pregnant or breast-feeding