Breast Cancer Clinical Trial

Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases

Summary

This phase II trial studies the effect of sacituzumab govitecan in treating patients with HER2-negative breast cancer that has spread to the brain (brain metastases). Sacituzumab govitecan is a monoclonal antibody, called sacituzumab, linked to a chemotherapy drug, called govitecan. Sacituzumab is a form of targeted therapy because it attaches to specific molecules on the surface of cancer cells, known as Trop-2 receptors, and delivers govitecan to kill them. Giving sacituzumab govitecan may shrink the cancer in the brain and/or extend the time until the cancer gets worse.

View Full Description

Full Description

PRIMARY OBJECTIVE:

I. To evaluate the intracranial objective response rate (ORR) (complete response [CR] or partial response [PR] by Response Assessment in Neuro-Oncology Brain Metastases [RANO-BM]) with sacituzumab govitecan (IMMU-132) in patients with HER2-negative metastatic breast cancer with brain involvement.

SECONDARY OBJECTIVES:

I. To evaluate bi-compartmental progression-free survival in this population. II. To evaluate overall survival in this population. III. To assess safety and tolerability of sacituzumab govitecan (IMMU-132) treatment in this population.

IV. To evaluate ORR by hormone-receptor (HR) subgroup (HR+, HR-).

BANKING OBJECTIVE:

I. To bank specimens for future correlative studies.

OUTLINE:

Patients receive sacituzumab govitecan intravenously (IV) over 1-3 hours on days 1 and 8. Cycles repeat every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity.

After completion of study registration, patients are followed up every 3 months for 1 year and then every 6 months for 1 year.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Participants must have histologically confirmed HER2-negative (per 2018 American Society of Clinical Oncology [ASCO]/College of American Pathologists [CAP] joint guideline) invasive breast cancer that has metastasized to the brain. NOTE: Pathology report must confirm HER2-negative invasive breast cancer. Brain metastases must be confirmed by radiology report
Participants must have an magnetic resonance imaging (MRI) of the brain within 28 days prior to registration and must have central nervous system metastases with at least one measurable brain metastasis >= 1.0 cm in size (per RANO-BM) that has not been irradiated, or has progressed despite prior radiation therapy (in the opinion of the treating physician). In the rare case that a previously irradiated brain metastasis is the sole target lesion and if there is concern about possible radiation necrosis, patient is eligible only if there is clear progression in the previously radiated lesion. Computed tomography (CT) of the head cannot substitute for brain MRI. All central nervous system (CNS) disease must be assessed and documented on the S2007 Brain Metastases Baseline Tumor Assessment Form
Participants may have measurable or non-measurable extracranial disease. All measurable disease must be assessed within 28 days prior to registration; all non-measurable disease must be assessed within 42 days prior to registration. Participants are NOT required to have extracranial disease, but must have scans done to document disease status at baseline. All extracranial disease must be assessed and documented on the Baseline Tumor Assessment Form (Response Evaluation Criteria in Solid Tumors [RECIST] 1.1). NOTE: Brain lesions should not be included on the Baseline Tumor Assessment Form (RECIST 1.1) for this study
Participants must have had CNS progression after previous CNS-directed therapy (radiation therapy, surgery, or any combination of therapy)
Participants must have resolution of adverse event(s) of the most recent prior systemic anti-cancer therapy to < grade 2, with the exception of alopecia and =< grade 2 neuropathy, which are allowed
Participants with a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
Participants must have Zubrod performance status 0 or 1
Participants must have history and physical exam obtained within 21 days prior to registration
Absolute neutrophil count (ANC) >= 1,500/mcL (obtained within 21 days prior to registration)
Platelet count >= 100,000/mcL (obtained within 21 days prior to registration)
Hemoglobin >= 9.0 g/dL (obtained within 21 days prior to registration)
Total bilirubin =< 1.5 times institutional upper limit of normal (ULN) (obtained within 21 days prior to registration)
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x institutional ULN (obtained within 21 days prior to registration)
Participants must have a serum creatinine =< 1.5 times the institutional upper limit of normal (IULN) OR measured OR calculated creatinine clearance >= 30 mL/min using the following Cockcroft-Gault Formula. This specimen must have been drawn and processed within 21 days prior to registration
Participants must have adequate cardiac function. Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification, and must be class 2B or better
Participants must be offered the opportunity to participate in specimen banking. With participant consent, specimens must be collected and submitted via the Southwest Oncology Group (SWOG) Specimen Tracking System
Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines

Exclusion Criteria:

Participants must not have had more than 2 seizures within 28 days prior to registration
Participants must not have received systemic therapy (including small-molecule kinase inhibitors) or non-cytotoxic hormonal therapy (e.g., tamoxifen) within 7 days prior to registration
Participants must not have received anti-cancer biologic agents (antibodies, immune modulators, vaccines, cytokines) within 21 days prior to registration
Participants must not have received nitrosoureas or mitomycin C within 42 days, metronomic/protracted low-dose chemotherapy within 14 days, or other cytotoxic chemotherapy within 28 days prior to registration
Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral agents that are strong CYP3A4 inhibitors or inducers and who are unwilling or unable to change to antiretroviral therapies without such interactions are ineligible because of the potential for pharmacokinetic interactions with sacituzumab govitecan (IMMU-132)
Due to potential drug interactions of anti-retroviral drugs with sacituzumab govitecan (IMMU-132), participants must not have known active or chronic hepatitis B virus (HBV) infection, requiring suppressive therapy or known active hepatitis C virus (HCV) infection. Participants with a known history of HCV infection must have been treated and cured
Participants must not have received enzyme-inducing anti-epileptic agents (e.g., carbamazepine, phenytoin, phenobarbital, primidone) within 7 days prior to registration or within 14 days of planned start of cycle 1, day 1 treatment, and participants must not be planning to receive enzyme-inducing anti-epileptic agents (e.g., carbamazepine, phenytoin, phenobarbital, primidone) for the duration of protocol treatment
Participants must not be receiving warfarin (or other coumarin derivatives) at time of registration or be planning to receive warfarin (or other coumarin derivatives) for the duration of protocol treatment. Participants who are able to switch to low molecular weight heparin (LMWH) or direct oral anticoagulants (DOACs) prior to date of registration (and plan to remain off of warfarin or other coumarin derivatives) for the duration of protocol treatment) are eligible
Patients must not be receiving or be planning to receive concomitantly any other anti-cancer therapy, including endocrine therapy. Note: Concomitant hormone replacement therapy is allowed
Participants must not have a condition requiring ongoing systemic treatment with corticosteroids (> 4 mg daily dexamethasone [or bioequivalent]) or other immunosuppressive medications within 7 days prior to the baseline MRI. Corticosteroids administration must be stable and planned to remain =< 4 mg daily for the duration of protocol treatment. However, use of corticosteroids for clinical symptoms is allowed based upon treating physician discretion
Participants must not have uncontrolled diabetes in the opinion of the treating investigator 21 days prior to registration
Participants must not be pregnant or nursing. Women of reproductive potential must have a negative serum or urine pregnancy test within 7 days prior to registration. Women and men of reproductive potential must have agreed to use an effective contraceptive method for the duration of protocol treatment and for at least 6 months after the last dose of sacituzumab govitecan (IMMU-132). A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate participant chooses to become heterosexually active during the time period for use of contraceptive measures outlined, he/she is responsible for beginning contraceptive measures

Study is for people with:

Breast Cancer

Phase:

Phase 2

Estimated Enrollment:

44

Study ID:

NCT04647916

Recruitment Status:

Recruiting

Sponsor:

Southwest Oncology Group

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There are 248 Locations for this study

See Locations Near You

Anchorage Associates in Radiation Medicine
Anchorage Alaska, 98508, United States
Anchorage Radiation Therapy Center
Anchorage Alaska, 99504, United States
Alaska Breast Care and Surgery LLC
Anchorage Alaska, 99508, United States
Alaska Oncology and Hematology LLC
Anchorage Alaska, 99508, United States
Alaska Women's Cancer Care
Anchorage Alaska, 99508, United States
Anchorage Oncology Centre
Anchorage Alaska, 99508, United States
Katmai Oncology Group
Anchorage Alaska, 99508, United States
Providence Alaska Medical Center
Anchorage Alaska, 99508, United States
Fairbanks Memorial Hospital
Fairbanks Alaska, 99701, United States More Info
Site Public Contact
Contact
907-458-3043
[email protected]
Nicholas DiBella
Principal Investigator
Cancer Center at Saint Joseph's
Phoenix Arizona, 85004, United States
University of Arizona Cancer Center-Orange Grove Campus
Tucson Arizona, 85704, United States More Info
Site Public Contact
Contact
520-694-8900
Pavani Chalasani
Principal Investigator
Banner University Medical Center - Tucson
Tucson Arizona, 85719, United States More Info
Site Public Contact
Contact
[email protected]
Pavani Chalasani
Principal Investigator
University of Arizona Cancer Center-North Campus
Tucson Arizona, 85719, United States More Info
Site Public Contact
Contact
800-327-2873
Pavani Chalasani
Principal Investigator
Mercy Hospital Fort Smith
Fort Smith Arkansas, 72903, United States
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs Arkansas, 71913, United States
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande California, 93420, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank California, 91505, United States
UC Irvine Health Cancer Center-Newport
Costa Mesa California, 92627, United States
Epic Care-Dublin
Dublin California, 94568, United States More Info
Site Public Contact
Contact
925-875-1677
Lisa Bailey
Principal Investigator
Bay Area Breast Surgeons Inc
Emeryville California, 94608, United States More Info
Site Public Contact
Contact
510-835-9900
Lisa Bailey
Principal Investigator
Epic Care Partners in Cancer Care
Emeryville California, 94608, United States More Info
Site Public Contact
Contact
510-629-6682
Lisa Bailey
Principal Investigator
Contra Costa Regional Medical Center
Martinez California, 94553, United States More Info
Site Public Contact
Contact
925-957-5400
Lisa Bailey
Principal Investigator
Alta Bates Summit Medical Center - Summit Campus
Oakland California, 94609, United States
Bay Area Tumor Institute
Oakland California, 94609, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange California, 92868, United States More Info
Site Public Contact
Contact
877-827-8839
[email protected]
Ritesh Parajuli
Principal Investigator
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo California, 93401, United States
Mission Hope Medical Oncology - Santa Maria
Santa Maria California, 93444, United States
Saint John's Cancer Institute
Santa Monica California, 90404, United States More Info
Site Public Contact
Contact
310-582-7448
Parvin F. Peddi
Principal Investigator
Epic Care Cyberknife Center
Walnut Creek California, 94597, United States More Info
Site Public Contact
Contact
510-465-8016
[email protected]
Lisa Bailey
Principal Investigator
Rocky Mountain Cancer Centers-Aurora
Aurora Colorado, 80012, United States More Info
Site Public Contact
Contact
303-777-2663
[email protected]
Nicholas DiBella
Principal Investigator
The Medical Center of Aurora
Aurora Colorado, 80012, United States
Boulder Community Foothills Hospital
Boulder Colorado, 80303, United States
Rocky Mountain Cancer Centers-Boulder
Boulder Colorado, 80304, United States More Info
Site Public Contact
Contact
303-777-2663
[email protected]
Nicholas DiBella
Principal Investigator
Rocky Mountain Cancer Centers - Centennial
Centennial Colorado, 80112, United States More Info
Site Public Contact
Contact
303-777-2663
[email protected]
Nicholas DiBella
Principal Investigator
Penrose-Saint Francis Healthcare
Colorado Springs Colorado, 80907, United States
Rocky Mountain Cancer Centers-Penrose
Colorado Springs Colorado, 80907, United States
The Women's Imaging Center
Denver Colorado, 80209, United States
Porter Adventist Hospital
Denver Colorado, 80210, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Colorado Blood Cancer Institute
Denver Colorado, 80218, United States
Presbyterian - Saint Lukes Medical Center - Health One
Denver Colorado, 80218, United States
Rocky Mountain Cancer Centers-Midtown
Denver Colorado, 80218, United States More Info
Site Public Contact
Contact
303-777-2663
[email protected]
Nicholas DiBella
Principal Investigator
Rocky Mountain Cancer Centers-Rose
Denver Colorado, 80220, United States More Info
Site Public Contact
Contact
303-777-2663
[email protected]
Nicholas DiBella
Principal Investigator
Rose Medical Center
Denver Colorado, 80220, United States
Western Surgical Care
Denver Colorado, 80220, United States
Mercy Medical Center
Durango Colorado, 81301, United States
Southwest Oncology PC
Durango Colorado, 81301, United States
Mountain Blue Cancer Care Center - Swedish
Englewood Colorado, 80113, United States More Info
Site Public Contact
Contact
303-777-2663
[email protected]
Nicholas DiBella
Principal Investigator
Rocky Mountain Cancer Centers - Swedish
Englewood Colorado, 80113, United States
Swedish Medical Center
Englewood Colorado, 80113, United States More Info
Site Public Contact
Contact
303-777-2663
[email protected]
Nicholas DiBella
Principal Investigator
The Melanoma and Skin Cancer Institute
Englewood Colorado, 80113, United States
North Colorado Medical Center
Greeley Colorado, 80631, United States More Info
Site Public Contact
Contact
303-777-2663
[email protected]
Nicholas DiBella
Principal Investigator
Rocky Mountain Cancer Centers-Lakewood
Lakewood Colorado, 80228, United States
Saint Anthony Hospital
Lakewood Colorado, 80228, United States
Rocky Mountain Cancer Centers-Littleton
Littleton Colorado, 80120, United States More Info
Site Public Contact
Contact
303-777-2663
[email protected]
Nicholas DiBella
Principal Investigator
Littleton Adventist Hospital
Littleton Colorado, 80122, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree Colorado, 80124, United States More Info
Site Public Contact
Contact
303-777-2663
[email protected]
Nicholas DiBella
Principal Investigator
Sky Ridge Medical Center
Lone Tree Colorado, 80124, United States
Longmont United Hospital
Longmont Colorado, 80501, United States
Rocky Mountain Cancer Centers-Longmont
Longmont Colorado, 80501, United States
McKee Medical Center
Loveland Colorado, 80539, United States More Info
Site Public Contact
Contact
303-777-2663
[email protected]
Nicholas DiBella
Principal Investigator
Parker Adventist Hospital
Parker Colorado, 80138, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Saint Mary Corwin Medical Center
Pueblo Colorado, 81004, United States
Rocky Mountain Cancer Centers-Thornton
Thornton Colorado, 80260, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah Georgia, 31405, United States More Info
Site Public Contact
Contact
912-819-5704
[email protected]
Alison E. Spellman
Principal Investigator
Saint Alphonsus Cancer Care Center-Boise
Boise Idaho, 83706, United States More Info
Site Public Contact
Contact
734-712-3671
[email protected]
John M. Schallenkamp
Principal Investigator
Saint Luke's Cancer Institute - Boise
Boise Idaho, 83712, United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell Idaho, 83605, United States More Info
Site Public Contact
Contact
734-712-3671
[email protected]
John M. Schallenkamp
Principal Investigator
Kootenai Health - Coeur d'Alene
Coeur d'Alene Idaho, 83814, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Walter Knox Memorial Hospital
Emmett Idaho, 83617, United States
Saint Luke's Cancer Institute - Fruitland
Fruitland Idaho, 83619, United States
Idaho Urologic Institute-Meridian
Meridian Idaho, 83642, United States
Saint Luke's Cancer Institute - Meridian
Meridian Idaho, 83642, United States
Saint Alphonsus Medical Center-Nampa
Nampa Idaho, 83686, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Saint Luke's Cancer Institute - Nampa
Nampa Idaho, 83686, United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls Idaho, 83854, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Kootenai Cancer Clinic
Sandpoint Idaho, 83864, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Saint Luke's Cancer Institute - Twin Falls
Twin Falls Idaho, 83301, United States
Saint Anthony's Health
Alton Illinois, 62002, United States
Rush - Copley Medical Center
Aurora Illinois, 60504, United States
Illinois CancerCare-Bloomington
Bloomington Illinois, 61704, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Canton
Canton Illinois, 61520, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Memorial Hospital of Carbondale
Carbondale Illinois, 62902, United States
SIH Cancer Institute
Carterville Illinois, 62918, United States
Illinois CancerCare-Carthage
Carthage Illinois, 62321, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Centralia Oncology Clinic
Centralia Illinois, 62801, United States
Northwestern University
Chicago Illinois, 60611, United States More Info
Site Public Contact
Contact
312-695-1301
[email protected]
Ami N. Shah
Principal Investigator
Carle on Vermilion
Danville Illinois, 61832, United States More Info
Site Public Contact
Contact
800-446-5532
[email protected]
Pratima Chalasani
Principal Investigator
Cancer Care Specialists of Illinois - Decatur
Decatur Illinois, 62526, United States More Info
Site Public Contact
Contact
217-876-4762
[email protected]
Bryan A. Faller
Principal Investigator
Decatur Memorial Hospital
Decatur Illinois, 62526, United States
Illinois CancerCare-Dixon
Dixon Illinois, 61021, United States More Info
Site Public Contact
Contact
815-285-7800
Bryan A. Faller
Principal Investigator
Carle Physician Group-Effingham
Effingham Illinois, 62401, United States More Info
Site Public Contact
Contact
800-446-5532
[email protected]
Pratima Chalasani
Principal Investigator
Crossroads Cancer Center
Effingham Illinois, 62401, United States More Info
Site Public Contact
Contact
217-876-4762
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Eureka
Eureka Illinois, 61530, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Galesburg
Galesburg Illinois, 61401, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Western Illinois Cancer Treatment Center
Galesburg Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic
Kewanee Illinois, 61443, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Macomb
Macomb Illinois, 61455, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Carle Physician Group-Mattoon/Charleston
Mattoon Illinois, 61938, United States More Info
Site Public Contact
Contact
800-446-5532
[email protected]
Pratima Chalasani
Principal Investigator
Good Samaritan Regional Health Center
Mount Vernon Illinois, 62864, United States
Cancer Care Center of O'Fallon
O'Fallon Illinois, 62269, United States More Info
Site Public Contact
Contact
217-876-4762
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Ottawa Clinic
Ottawa Illinois, 61350, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Pekin
Pekin Illinois, 61554, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Peoria
Peoria Illinois, 61615, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Methodist Medical Center of Illinois
Peoria Illinois, 61636, United States
Illinois CancerCare-Peru
Peru Illinois, 61354, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Valley Radiation Oncology
Peru Illinois, 61354, United States
Illinois CancerCare-Princeton
Princeton Illinois, 61356, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Southern Illinois University School of Medicine
Springfield Illinois, 62702, United States More Info
Site Public Contact
Contact
217-545-7929
Bryan A. Faller
Principal Investigator
Springfield Clinic
Springfield Illinois, 62702, United States More Info
Site Public Contact
Contact
800-444-7541
Bryan A. Faller
Principal Investigator
Memorial Medical Center
Springfield Illinois, 62781, United States More Info
Site Public Contact
Contact
217-528-7541
[email protected]
Bryan A. Faller
Principal Investigator
Carle Cancer Center
Urbana Illinois, 61801, United States More Info
Site Public Contact
Contact
800-446-5532
[email protected]
Pratima Chalasani
Principal Investigator
The Carle Foundation Hospital
Urbana Illinois, 61801, United States
Illinois CancerCare - Washington
Washington Illinois, 61571, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Rush-Copley Healthcare Center
Yorkville Illinois, 60560, United States
Reid Health
Richmond Indiana, 47374, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Howard M. Gross
Principal Investigator
Mary Greeley Medical Center
Ames Iowa, 50010, United States More Info
Site Public Contact
Contact
515-956-4132
Debra M. Prow
Principal Investigator
McFarland Clinic PC - Ames
Ames Iowa, 50010, United States More Info
Site Public Contact
Contact
515-239-4734
[email protected]
Debra M. Prow
Principal Investigator
McFarland Clinic PC-Boone
Boone Iowa, 50036, United States More Info
Site Public Contact
Contact
515-956-4132
Debra M. Prow
Principal Investigator
Saint Anthony Regional Hospital
Carroll Iowa, 51401, United States More Info
Site Public Contact
Contact
515-689-7658
[email protected]
Joshua Lukenbill
Principal Investigator
Medical Oncology and Hematology Associates-West Des Moines
Clive Iowa, 50325, United States
Mercy Cancer Center-West Lakes
Clive Iowa, 50325, United States
Alegent Health Mercy Hospital
Council Bluffs Iowa, 51503, United States
Greater Regional Medical Center
Creston Iowa, 50801, United States
Iowa Methodist Medical Center
Des Moines Iowa, 50309, United States
Medical Oncology and Hematology Associates-Des Moines
Des Moines Iowa, 50309, United States More Info
Site Public Contact
Contact
515-282-2921
Joshua Lukenbill
Principal Investigator
Broadlawns Medical Center
Des Moines Iowa, 50314, United States More Info
Site Public Contact
Contact
515-282-2200
Joshua Lukenbill
Principal Investigator
Medical Oncology and Hematology Associates-Laurel
Des Moines Iowa, 50314, United States
Mercy Medical Center - Des Moines
Des Moines Iowa, 50314, United States
Iowa Lutheran Hospital
Des Moines Iowa, 50316, United States
McFarland Clinic PC-Trinity Cancer Center
Fort Dodge Iowa, 50501, United States More Info
Site Public Contact
Contact
515-956-4132
Debra M. Prow
Principal Investigator
Trinity Regional Medical Center
Fort Dodge Iowa, 50501, United States
McFarland Clinic PC-Jefferson
Jefferson Iowa, 50129, United States More Info
Site Public Contact
Contact
515-956-4132
Debra M. Prow
Principal Investigator
McFarland Clinic PC-Marshalltown
Marshalltown Iowa, 50158, United States More Info
Site Public Contact
Contact
515-956-4132
Debra M. Prow
Principal Investigator
Methodist West Hospital
West Des Moines Iowa, 50266, United States
Mercy Medical Center-West Lakes
West Des Moines Iowa, 50266, United States
Central Care Cancer Center - Garden City
Garden City Kansas, 67846, United States
Central Care Cancer Center - Great Bend
Great Bend Kansas, 67530, United States
HaysMed University of Kansas Health System
Hays Kansas, 67601, United States More Info
Site Public Contact
Contact
785-623-5774
Priyanka Sharma
Principal Investigator
Lawrence Memorial Hospital
Lawrence Kansas, 66044, United States More Info
Site Public Contact
Contact
785-505-2800
[email protected]
Priyanka Sharma
Principal Investigator
Olathe Health Cancer Center
Olathe Kansas, 66061, United States More Info
Site Public Contact
Contact
913-355-8000
[email protected]
Priyanka Sharma
Principal Investigator
University of Kansas Cancer Center-Overland Park
Overland Park Kansas, 66210, United States More Info
Site Public Contact
Contact
913-588-3671
[email protected]
Priyanka Sharma
Principal Investigator
Ascension Via Christi - Pittsburg
Pittsburg Kansas, 66762, United States
Salina Regional Health Center
Salina Kansas, 67401, United States More Info
Site Public Contact
Contact
785-452-7038
[email protected]
Priyanka Sharma
Principal Investigator
University of Kansas Health System Saint Francis Campus
Topeka Kansas, 66606, United States More Info
Site Public Contact
Contact
785-295-8000
Priyanka Sharma
Principal Investigator
University of Kansas Hospital-Westwood Cancer Center
Westwood Kansas, 66205, United States More Info
Site Public Contact
Contact
913-588-3671
[email protected]
Priyanka Sharma
Principal Investigator
Flaget Memorial Hospital
Bardstown Kentucky, 40004, United States
Commonwealth Cancer Center-Corbin
Corbin Kentucky, 40701, United States
Saint Joseph Radiation Oncology Resource Center
Lexington Kentucky, 40504, United States
Saint Joseph Hospital East
Lexington Kentucky, 40509, United States
Saint Joseph London
London Kentucky, 40741, United States
Jewish Hospital
Louisville Kentucky, 40202, United States
Saints Mary and Elizabeth Hospital
Louisville Kentucky, 40215, United States
UofL Health Medical Center Northeast
Louisville Kentucky, 40245, United States
Jewish Hospital Medical Center South
Shepherdsville Kentucky, 40165, United States
Walter Reed National Military Medical Center
Bethesda Maryland, 20889, United States More Info
Site Public Contact
Contact
301-319-2100
Jeremy G. Perkins
Principal Investigator
Dana-Farber Cancer Institute
Boston Massachusetts, 02215, United States More Info
Site Public Contact
Contact
877-442-3324
Nancy U. Lin
Principal Investigator
Hickman Cancer Center
Adrian Michigan, 49221, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor Michigan, 48109, United States More Info
Site Public Contact
Contact
800-865-1125
Aki Morikawa
Principal Investigator
Toledo Clinic Cancer Centers-Monroe
Monroe Michigan, 48162, United States
Ascension Providence Hospitals - Novi
Novi Michigan, 48374, United States More Info
Site Public Contact
Contact
248-849-5332
[email protected]
Cynthia M. Vakhariya
Principal Investigator
Ascension Providence Hospitals - Southfield
Southfield Michigan, 48075, United States More Info
Site Public Contact
Contact
248-849-5332
[email protected]
Cynthia M. Vakhariya
Principal Investigator
Mayo Clinic in Rochester
Rochester Minnesota, 55905, United States More Info
Site Public Contact
Contact
855-776-0015
Roberto A. Leon-Ferre
Principal Investigator
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus Mississippi, 39705, United States More Info
Site Public Contact
Contact
901-226-1366
[email protected]
Philip E. Lammers
Principal Investigator
Baptist Cancer Center-Grenada
Grenada Mississippi, 38901, United States More Info
Site Public Contact
Contact
901-226-1366
[email protected]
Philip E. Lammers
Principal Investigator
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford Mississippi, 38655, United States More Info
Site Public Contact
Contact
901-226-1366
[email protected]
Philip E. Lammers
Principal Investigator
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven Mississippi, 38671, United States More Info
Site Public Contact
Contact
901-226-1366
[email protected]
Philip E. Lammers
Principal Investigator
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin Missouri, 63011, United States
Central Care Cancer Center - Bolivar
Bolivar Missouri, 65613, United States
Saint Francis Medical Center
Cape Girardeau Missouri, 63703, United States More Info
Site Public Contact
Contact
573-334-2230
[email protected]
Bryan A. Faller
Principal Investigator
Southeast Cancer Center
Cape Girardeau Missouri, 63703, United States
Parkland Health Center - Farmington
Farmington Missouri, 63640, United States
Capital Region Southwest Campus
Jefferson City Missouri, 65109, United States
Freeman Health System
Joplin Missouri, 64804, United States More Info
Site Public Contact
Contact
417-347-4030
[email protected]
Jay W. Carlson
Principal Investigator
Mercy Hospital Joplin
Joplin Missouri, 64804, United States
Truman Medical Centers
Kansas City Missouri, 64108, United States More Info
Site Public Contact
Contact
816-404-4375
Priyanka Sharma
Principal Investigator
University of Kansas Cancer Center - North
Kansas City Missouri, 64154, United States More Info
Site Public Contact
Contact
913-588-3671
[email protected]
Priyanka Sharma
Principal Investigator
University of Kansas Cancer Center - Lee's Summit
Lee's Summit Missouri, 64064, United States More Info
Site Public Contact
Contact
913-588-3671
[email protected]
Priyanka Sharma
Principal Investigator
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City Missouri, 64116, United States More Info
Site Public Contact
Contact
913-588-3671
[email protected]
Priyanka Sharma
Principal Investigator
Delbert Day Cancer Institute at PCRMC
Rolla Missouri, 65401, United States
Mercy Clinic-Rolla-Cancer and Hematology
Rolla Missouri, 65401, United States
Heartland Regional Medical Center
Saint Joseph Missouri, 64506, United States
Saint Louis Cancer and Breast Institute-South City
Saint Louis Missouri, 63109, United States
Mercy Hospital South
Saint Louis Missouri, 63128, United States
Missouri Baptist Medical Center
Saint Louis Missouri, 63131, United States
Mercy Hospital Saint Louis
Saint Louis Missouri, 63141, United States More Info
Site Public Contact
Contact
314-251-7066
Jay W. Carlson
Principal Investigator
Sainte Genevieve County Memorial Hospital
Sainte Genevieve Missouri, 63670, United States
Mercy Hospital Springfield
Springfield Missouri, 65804, United States
CoxHealth South Hospital
Springfield Missouri, 65807, United States
Missouri Baptist Sullivan Hospital
Sullivan Missouri, 63080, United States
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills Missouri, 63127, United States
Mercy Hospital Washington
Washington Missouri, 63090, United States
Community Hospital of Anaconda
Anaconda Montana, 59711, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Billings Clinic Cancer Center
Billings Montana, 59101, United States More Info
Site Public Contact
Contact
800-996-2663
[email protected]
John M. Schallenkamp
Principal Investigator
Bozeman Deaconess Hospital
Bozeman Montana, 59715, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Benefis Healthcare- Sletten Cancer Institute
Great Falls Montana, 59405, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Great Falls Clinic
Great Falls Montana, 59405, United States
Kalispell Regional Medical Center
Kalispell Montana, 59901, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Saint Patrick Hospital - Community Hospital
Missoula Montana, 59802, United States
Community Medical Hospital
Missoula Montana, 59804, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
CHI Health Saint Francis
Grand Island Nebraska, 68803, United States
CHI Health Good Samaritan
Kearney Nebraska, 68847, United States
Saint Elizabeth Regional Medical Center
Lincoln Nebraska, 68510, United States
Alegent Health Immanuel Medical Center
Omaha Nebraska, 68122, United States
Alegent Health Bergan Mercy Medical Center
Omaha Nebraska, 68124, United States
Alegent Health Lakeside Hospital
Omaha Nebraska, 68130, United States
Creighton University Medical Center
Omaha Nebraska, 68131, United States
Midlands Community Hospital
Papillion Nebraska, 68046, United States
Solinsky Center for Cancer Care
Manchester New Hampshire, 03103, United States More Info
Site Public Contact
Contact
800-339-6484
Douglas J. Weckstein
Principal Investigator
University of New Mexico Cancer Center
Albuquerque New Mexico, 87102, United States More Info
Site Public Contact
Contact
505-925-0366
[email protected]
Ursa A. Brown-Glaberman
Principal Investigator
Northwell Health/Center for Advanced Medicine
Lake Success New York, 11042, United States More Info
Site Public Contact
Contact
516-734-8896
Kit L. Cheng
Principal Investigator
Good Samaritan Hospital Medical Center
West Islip New York, 11795, United States More Info
Site Public Contact
Contact
631-376-4444
Ellis G. Levine
Principal Investigator
Southeastern Medical Oncology Center-Clinton
Clinton North Carolina, 28328, United States More Info
Site Public Contact
Contact
919-587-9084
[email protected]
Samer S. Kasbari
Principal Investigator
Southeastern Medical Oncology Center-Goldsboro
Goldsboro North Carolina, 27534, United States More Info
Site Public Contact
Contact
919-587-9084
[email protected]
Samer S. Kasbari
Principal Investigator
Southeastern Medical Oncology Center-Jacksonville
Jacksonville North Carolina, 28546, United States More Info
Site Public Contact
Contact
910-587-9084
[email protected]
Samer S. Kasbari
Principal Investigator
Dayton Physicians LLC-Miami Valley South
Centerville Ohio, 45459, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Howard M. Gross
Principal Investigator
Miami Valley Hospital South
Centerville Ohio, 45459, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Howard M. Gross
Principal Investigator
Good Samaritan Hospital - Cincinnati
Cincinnati Ohio, 45220, United States
Bethesda North Hospital
Cincinnati Ohio, 45242, United States
TriHealth Cancer Institute-Westside
Cincinnati Ohio, 45247, United States
TriHealth Cancer Institute-Anderson
Cincinnati Ohio, 45255, United States
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland Ohio, 44111, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Megan L. Kruse
Principal Investigator
Cleveland Clinic Foundation
Cleveland Ohio, 44195, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Megan L. Kruse
Principal Investigator
Miami Valley Hospital
Dayton Ohio, 45409, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Howard M. Gross
Principal Investigator
Dayton Physician LLC-Miami Valley Hospital North
Dayton Ohio, 45415, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Howard M. Gross
Principal Investigator
Miami Valley Hospital North
Dayton Ohio, 45415, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Howard M. Gross
Principal Investigator
Armes Family Cancer Center
Findlay Ohio, 45840, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Howard M. Gross
Principal Investigator
Dayton Physicians LLC-Atrium
Franklin Ohio, 45005, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Howard M. Gross
Principal Investigator
Greater Dayton Cancer Center
Kettering Ohio, 45409, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Howard M. Gross
Principal Investigator
Kettering Medical Center
Kettering Ohio, 45429, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Howard M. Gross
Principal Investigator
Cleveland Clinic Cancer Center Mansfield
Mansfield Ohio, 44906, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Megan L. Kruse
Principal Investigator
Hillcrest Hospital Cancer Center
Mayfield Heights Ohio, 44124, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Megan L. Kruse
Principal Investigator
North Coast Cancer Care
Sandusky Ohio, 44870, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Megan L. Kruse
Principal Investigator
Springfield Regional Cancer Center
Springfield Ohio, 45504, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Howard M. Gross
Principal Investigator
Mercy Health - Saint Anne Hospital
Toledo Ohio, 43623, United States
Toledo Clinic Cancer Centers-Toledo
Toledo Ohio, 43623, United States More Info
Site Public Contact
Contact
800-444-3561
Rex B. Mowat
Principal Investigator
South Pointe Hospital
Warrensville Heights Ohio, 44122, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Megan L. Kruse
Principal Investigator
Mercy Hospital Oklahoma City
Oklahoma City Oklahoma, 73120, United States
Saint Alphonsus Medical Center-Baker City
Baker City Oregon, 97814, United States
Saint Charles Health System
Bend Oregon, 97701, United States
Clackamas Radiation Oncology Center
Clackamas Oregon, 97015, United States
Providence Cancer Institute Clackamas Clinic
Clackamas Oregon, 97015, United States More Info
Site Public Contact
Contact
503-215-2614
[email protected]
Charles W. Drescher
Principal Investigator
Bay Area Hospital
Coos Bay Oregon, 97420, United States
Providence Newberg Medical Center
Newberg Oregon, 97132, United States More Info
Site Public Contact
Contact
503-215-2614
[email protected]
Charles W. Drescher
Principal Investigator
Saint Alphonsus Medical Center-Ontario
Ontario Oregon, 97914, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Providence Portland Medical Center
Portland Oregon, 97213, United States More Info
Site Public Contact
Contact
503-215-2614
[email protected]
Charles W. Drescher
Principal Investigator
Providence Saint Vincent Medical Center
Portland Oregon, 97225, United States More Info
Site Public Contact
Contact
503-215-2614
[email protected]
Charles W. Drescher
Principal Investigator
Saint Charles Health System-Redmond
Redmond Oregon, 97756, United States
UPMC Camp Hill
Camp Hill Pennsylvania, 17011, United States More Info
Site Public Contact
Contact
717-975-8900
Adam M. Brufsky
Principal Investigator
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg Pennsylvania, 17109, United States More Info
Site Public Contact
Contact
717-724-6765
[email protected]
Adam M. Brufsky
Principal Investigator
UPMC-Mercy Hospital
Pittsburgh Pennsylvania, 15219, United States More Info
Site Public Contact
Contact
800-533-8762
Adam M. Brufsky
Principal Investigator
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh Pennsylvania, 15232, United States More Info
Site Public Contact
Contact
412-647-8073
Adam M. Brufsky
Principal Investigator
UPMC Susquehanna
Williamsport Pennsylvania, 17701, United States More Info
Site Public Contact
Contact
800-598-4282
Adam M. Brufsky
Principal Investigator
UPMC Memorial
York Pennsylvania, 17408, United States More Info
Site Public Contact
Contact
717-724-6760
Adam M. Brufsky
Principal Investigator
Gibbs Cancer Center-Gaffney
Gaffney South Carolina, 29341, United States
Gibbs Cancer Center-Pelham
Greer South Carolina, 29651, United States
Spartanburg Medical Center
Spartanburg South Carolina, 29303, United States More Info
Site Public Contact
Contact
864-560-6104
[email protected]
Amanda R. Hathaway
Principal Investigator
MGC Hematology Oncology-Union
Union South Carolina, 29379, United States
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville Tennessee, 38017, United States More Info
Site Public Contact
Contact
901-226-1366
[email protected]
Philip E. Lammers
Principal Investigator
Vanderbilt-Ingram Cancer Center Cool Springs
Franklin Tennessee, 37067, United States
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis Tennessee, 38120, United States More Info
Site Public Contact
Contact
901-226-1366
[email protected]
Philip E. Lammers
Principal Investigator
Vanderbilt Breast Center at One Hundred Oaks
Nashville Tennessee, 37204, United States More Info
Site Public Contact
Contact
800-811-8480
Laura C. Kennedy
Principal Investigator
Vanderbilt University/Ingram Cancer Center
Nashville Tennessee, 37232, United States More Info
Site Public Contact
Contact
800-811-8480
Laura C. Kennedy
Principal Investigator
Saint Joseph Regional Cancer Center
Bryan Texas, 77802, United States
M D Anderson Cancer Center
Houston Texas, 77030, United States More Info
Site Public Contact
Contact
877-632-6789
[email protected]
Nuhad K. Ibrahim
Principal Investigator
University of Texas Health Science Center at San Antonio
San Antonio Texas, 78229, United States More Info
Site Public Contact
Contact
210-450-3800
[email protected]
Virginia G. Kaklamani
Principal Investigator
Providence Regional Cancer System-Aberdeen
Aberdeen Washington, 98520, United States
PeaceHealth Saint Joseph Medical Center
Bellingham Washington, 98225, United States
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton Washington, 98310, United States More Info
Site Public Contact
Contact
308-398-6518
[email protected]
Richard L. Deming
Principal Investigator
Harrison Medical Center
Bremerton Washington, 98310, United States
Highline Medical Center-Main Campus
Burien Washington, 98166, United States
Providence Regional Cancer System-Centralia
Centralia Washington, 98531, United States
Swedish Cancer Institute-Edmonds
Edmonds Washington, 98026, United States
Saint Elizabeth Hospital
Enumclaw Washington, 98022, United States
Providence Regional Cancer Partnership
Everett Washington, 98201, United States
Saint Francis Hospital
Federal Way Washington, 98003, United States
Swedish Cancer Institute-Issaquah
Issaquah Washington, 98029, United States
Kadlec Clinic Hematology and Oncology
Kennewick Washington, 99336, United States More Info
Site Public Contact
Contact
509-783-4637
[email protected]
Charles W. Drescher
Principal Investigator
Providence Regional Cancer System-Lacey
Lacey Washington, 98503, United States
Saint Clare Hospital
Lakewood Washington, 98499, United States
PeaceHealth Saint John Medical Center
Longview Washington, 98632, United States
Jefferson Healthcare
Port Townsend Washington, 98368, United States More Info
Site Public Contact
Contact
360-344-3091
Nicholas DiBella
Principal Investigator
Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo Washington, 98370, United States
Pacific Gynecology Specialists
Seattle Washington, 98104, United States
Swedish Medical Center-Ballard Campus
Seattle Washington, 98107, United States
Swedish Medical Center-First Hill
Seattle Washington, 98122, United States
Swedish Medical Center-Cherry Hill
Seattle Washington, 98122, United States
PeaceHealth United General Medical Center
Sedro-Woolley Washington, 98284, United States
Providence Regional Cancer System-Shelton
Shelton Washington, 98584, United States
Franciscan Research Center-Northwest Medical Plaza
Tacoma Washington, 98405, United States
Northwest Medical Specialties PLLC
Tacoma Washington, 98405, United States
PeaceHealth Southwest Medical Center
Vancouver Washington, 98664, United States More Info
Site Public Contact
Contact
360-514-3940
[email protected]
Charles W. Drescher
Principal Investigator
Providence Saint Mary Regional Cancer Center
Walla Walla Washington, 99362, United States
Providence Regional Cancer System-Yelm
Yelm Washington, 98597, United States
Cheyenne Regional Medical Center-West
Cheyenne Wyoming, 82001, United States
Billings Clinic-Cody
Cody Wyoming, 82414, United States
Welch Cancer Center
Sheridan Wyoming, 82801, United States

How clear is this clinincal trial information?

Study is for people with:

Breast Cancer

Phase:

Phase 2

Estimated Enrollment:

44

Study ID:

NCT04647916

Recruitment Status:

Recruiting

Sponsor:


Southwest Oncology Group

How clear is this clinincal trial information?

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