Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer

Key Inclusion Criteria:

Patients must be at least 18 years of age.
Histologically documented HER2-positive early breast cancer (EBC) participants, including clinical stage at presentation (based on mammogram or breast MRI assessment): T0-4 (inclusive of inflammatory breast cancer), N1-3, M0 or ≥ T3, N0, M0 as determined by the AJCC staging system, 8th edition
ECOG performance status of 0 or 1 at randomization
Adequate organ and bone marrow function
LVEF ≥ 50% within 28 days before randomization
FFPE tissue block (2 cores) or 20 freshly-cut, serial tumor slides for HER2 assessment by central lab. If blocks are incomplete or fewer than 20 slides are available, participants may be eligible following discussion with the AstraZeneca Study Physician

Exclusion Criteria:

prior history of invasive breast cancer
stage IV breast cancer (determined by AJCC staging system)
any primary malignancy within 3 years (except resected non-melanoma skin cancer, curatively treated in situ disease) Note: This includes a second current breast primary malignancy (ie, bilateral breast cancer)
history of DCIS (except those treated with mastectomy >5 years prior to current diagnosis)
History of, or current, ILD/pneumonitis
Prior systemic therapy for the treatment of breast cancer
Previous treatment with anthracyclines, cyclophosphamide or taxanes for any malignancy