Chronic Lymphocytic Leukemia Clinical Trial

Ruxolitinib Phosphate in Reducing Fatigue in Patients With Chronic Lymphocytic Leukemia

Summary

This phase II trial studies how well ruxolitinib phosphate works in reducing fatigue in patients with leukemia-cll/" >chronic lymphocytic leukemia. Ruxolitinib phosphate may stop the growth of cancer cells by blocking a protein called Janus kinase (JAK) that is needed for cell growth and may also help control fatigue, decrease the size of lymph nodes and/or lower the number of chronic lymphocytic leukemia cells in the blood.

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Full Description

PRIMARY OBJECTIVE:

I. To estimate the reduction in fatigue as measured by the Brief Fatigue Inventory (BFI) of patients with chronic lymphocytic leukemia (CLL) who do not require anti-neoplastic therapy according to the International Workshop on Chronic Lymphocytic Leukemia (IWCLL) 2008 recommendations.

SECONDARY OBJECTIVE:

I. To estimate the reduction in other symptoms using the M. D. Anderson Symptom Inventory (MDASI) and to assess disease burden and response by the IWCLL 2008 response criteria.

OUTLINE:

Patients receive ruxolitinib phosphate orally (PO) twice daily (BID) (approximately 12 hours apart) for up to 2 years in the absence of disease progression or unacceptable toxicity.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Subjects who are able to understand and sign an informed consent document
Subjects must be diagnosed with CLL and do not meet the IWCLL criteria for treatment
Patients may have been previously treated or previously untreated
Symptomatic patients with a BFI symptom scale of 2 points or greater
Subjects with hemoglobin values at the screening visit equal to or greater than 12.0 g/dL
Subjects with a platelet count of at least 75 x 10^9/L at the screening visit
Subjects with an absolute neutrophil count (ANC) of equal to or higher than 0.5 x 10^9/L at the screening visit
Subjects must have discontinued all drugs used to treat CLL no later than day -30
Subjects with an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2

Exclusion Criteria:

Females who are pregnant or are currently breastfeeding

Subjects of childbearing potential who are unwilling to take appropriate precautions (throughout the study from screening, including 30 days after discontinuation of the study drug) to avoid becoming pregnant or fathering a child

Females of non-childbearing potential are defined as women who (a) are equal to or greater than 55 years of age with history of amenorrhea for 1 year, or (b) are surgically sterile for at least 3 months

For females of childbearing potential, or for males, appropriate precautions are those that are at least 99% effective in preventing the occurrence of pregnancy; these methods should be communicated to the subjects and their understanding confirmed:

Complete abstinence from sexual intercourse
Double barrier methods
Condom with spermicide in conjunction with use of an intrauterine device (IUD)
Condom with spermicide in conjunction with use of a diaphragm
Oral, injectable, or implanted contraceptives
Tubal ligation or vasectomy (surgical sterilization)
Subjects with recent history of inadequate bone marrow reserve as demonstrated by previous transfusions except for acute blood loss (e.g. surgery) in the month prior to screening
Alanine aminotransferase (ALT) > 2.5 x upper limit of normal (ULN)
Modification of diet in renal disease (MDRD) calculated glomerular filtration rate (GFR) < 30 mL/min
Subjects with active uncontrolled infection or who are human immunodeficiency virus (HIV) positive (subjects with acute infections requiring treatment should delay screening/enrollment until the course of therapy has been completed and the event is considered controlled)
Subjects with an invasive malignancy over the previous 2 years except treated basal or squamous carcinomas of the skin completely resected intraepithelial carcinoma of the cervix and completely resected papillary thyroid and follicular thyroid cancers; other completely resected cancers greater than 2 years may be considered after review by the principal investigator (PI)
Subjects with clinically significant uncontrolled cardiac disease
Subjects being treated concurrently with any prohibited medications, including investigational medication, rifampin, St. John's wort, and potent cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) inhibitors (excluding ketoconazole) unless continuation of such medications are determined by the investigator to be in the best interest of the patient
Subjects who have previously received JAK inhibitor therapy
Subjects with active alcohol or drug addiction that would interfere with their ability to comply with the study requirements
Subjects with any concurrent condition that, in the investigator's opinion, would jeopardize the safety of the subject or compliance with the protocol
Subjects who have unknown transfusion history for at least the 12 weeks prior to screening
Subjects who are unable to complete the symptom diary
Subjects who will need conventional therapy during the course of the study

Study is for people with:

Chronic Lymphocytic Leukemia

Phase:

Phase 2

Estimated Enrollment:

10

Study ID:

NCT02131584

Recruitment Status:

Active, not recruiting

Sponsor:

M.D. Anderson Cancer Center

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There is 1 Location for this study

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M D Anderson Cancer Center
Houston Texas, 77030, United States

How clear is this clinincal trial information?

Study is for people with:

Chronic Lymphocytic Leukemia

Phase:

Phase 2

Estimated Enrollment:

10

Study ID:

NCT02131584

Recruitment Status:

Active, not recruiting

Sponsor:


M.D. Anderson Cancer Center

How clear is this clinincal trial information?

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