Study of Motexafin Gadolinium (MGd) in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Inclusion Criteria:

≥ 18 years old
CLL as defined by the NCI 96 criteria (exception; patients may have bright surface immunoglobulin staining if negative for t[11;14] translocation or cyclin D1) or SLL as defined by WHO classification criteria and is refractory or relapsed as defined by one of the following: 1) Refractory disease- progressive disease while on therapy, or 2) Relapsed disease progressive disease after at least one treatment course of therapy with disease response or stabilization
ECOG performance status score of 0, 1, or 2
Willing and able to provide written informed consent

Exclusion Criteria:

Laboratory Values of:

Platelet count < 30,000/µL
AST or ALT > 2 x ULN (upper limit of normal)
Total bilirubin > 2 x ULN
Creatinine > 2.0 mg/dL

and

Chemotherapy, radiation therapy, immunotherapy, systemic corticosteroids (> 10 mg oral prednisone or equivalent), or systemic biologic anticancer therapy within 21 days before beginning study treatment
Greater than three prior regimens (where a regimen is defined as a treatment for CLL/SLL given initially or after disease progression)
Uncontrolled hypertension
Known history of porphyria (testing not required at screening)
Known history of glucose-6-phosphate dehydrogenase (G6PD) deficiency (testing not required at screening)
Known history of HIV infection (testing not required at screening)
Pregnant or lactating (pregnancy test is required for all female patients of childbearing potential)
Woman of childbearing potential or sexually active man unwilling to use adequate contraceptive protection
Physical or mental condition that makes patient unable to complete specified follow-up assessments