Chronic Lymphocytic Leukemia Clinical Trial
Study of TG-1801 Alone or in Combination With Ublituximab in Subjects With B-Cell Lymphoma or Chronic Lymphocytic Leukemia
A Phase 1b Multi-cohort Study of TG-1801 Alone or in Combination with Ublituximab in Subjects with B-Cell Lymphoma or Chronic Lymphocytic Leukemia
B-cell non-Hodgkin lymphoma (NHL) including Richter's Transformation (RT) and transformed follicular lymphoma (FL), that warrants systemic therapy
Chronic Lymphocytic Leukemia (leukemia-cll/" >CLL), that warrants systemic therapy as defined by International Workshop on Chronic Lymphocytic Leukemia (iwCLL) (Hallek 2018)
NHL subjects: relapsed to or refractory after at least two prior standard systemic therapies (excluding antibiotics)
RT subjects: relapsed or refractory after at least two prior lines of therapy for CLL/ Small lymphocytic lymphoma (SLL) or RT
CLL subjects: relapsed to or refractory after at least two prior standard therapies
Measurable disease defined as:
NHL (including SLL): at least 1 measurable disease lesion > 1.5 centimeters (cm)
CLL: at least 1 measurable disease lesion
Prior therapy with any agent blocking the CD47/SIRPα pathway or any previous CD19 targeting therapy,
Subjects receiving cancer therapy (i.e. chemotherapy, radiation therapy, immunotherapy, biologic therapy, hormonal therapy, surgery and/or tumor embolization) or any investigational drug within 21 days of Cycle 1 Day 1.
Prior autologous stem cell transplant (SCT) within 6 months.
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There are 5 Locations for this study
Fayetteville Arkansas, 72703, United States
Hackensack New Jersey, 07601, United States
Chattanooga Tennessee, 37404, United States
Nashville Tennessee, 37203, United States
Houston Texas, 77030, United States
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