Chronic Lymphocytic Leukemia Clinical Trial
Theophylline in Treating Patients With In Situ, Stage I, or Stage II Chronic Lymphocytic Leukemia
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of theophylline in treating patients who have in situ, stage I, or stage II leukemia-cll/" >chronic lymphocytic leukemia.
Full Description
OBJECTIVES: I. Determine the response rate in asymptomatic patients with stage 0, I, or II B-cell chronic lymphocytic leukemia treated with theophylline. II. Determine the toxicity of this treatment in these patients.
OUTLINE: Patients receive oral theophylline daily. Daily treatment continues for a maximum of 6 months in the absence of disease progression or unacceptable toxicity. Patients are followed every 4 months for 1 year.
PROJECTED ACCRUAL: A total of 35 patients will be accrued for this study over approximately 10 months.
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically proven stage 0, I, or II B-cell chronic lymphocytic leukemia Stable disease that would otherwise be observed
PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy: At least 1 year Hematopoietic: Absolute lymphocyte count greater than 5,000/mm3 Mature lymphocytes with less than 55% prolymphocytes, atypical lymphocytes, or lymphoblasts Bone marrow with at least 30% lymphocytes Hepatic: No cirrhosis Renal: Not specified Cardiovascular: No history of unstable cardiac arrhythmia No active congestive heart failure Other: No history of uncontrolled seizure disorder Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No other concurrent condition that would make life expectancy less than 1 year
PRIOR CONCURRENT THERAPY: Biologic therapy: No concurrent interferon alfa Chemotherapy: No prior chemotherapy No concurrent chemotherapy Endocrine therapy: At least 3 months since prior corticosteroids No concurrent corticosteroids Radiotherapy: Not specified Surgery: Not specified
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There are 66 Locations for this study
Scottsdale Arizona, 85259, United States
Los Angeles California, 91010, United States
Palo Alto California, 94304, United States
Stanford California, 94305, United States
Denver Colorado, 80209, United States
Wilmington Delaware, 19899, United States
Washington District of Columbia, 20307, United States
Gainesville Florida, 32608, United States
Miami Florida, 33136, United States
Tampa Florida, 33612, United States
Tampa Florida, 33612, United States
Atlanta Georgia, 30322, United States
Decatur Georgia, 30033, United States
Chicago Illinois, 60611, United States
Chicago Illinois, 60611, United States
Evanston Illinois, 60201, United States
Peoria Illinois, 61602, United States
Springfield Illinois, 62526, United States
Urbana Illinois, 61801, United States
Indianapolis Indiana, 46202, United States
Indianapolis Indiana, 46202, United States
Cedar Rapids Iowa, 52403, United States
Des Moines Iowa, 10309, United States
Wichita Kansas, 67214, United States
New Orleans Louisiana, 70112, United States
New Orleans Louisiana, 70121, United States
Baltimore Maryland, 21287, United States
Boston Massachusetts, 02111, United States
Boston Massachusetts, 02215, United States
Ann Arbor Michigan, 48106, United States
Kalamazoo Michigan, 49007, United States
Duluth Minnesota, 55805, United States
Minneapolis Minnesota, 55417, United States
Rochester Minnesota, 55905, United States
Saint Louis Park Minnesota, 55416, United States
Omaha Nebraska, 68131, United States
Las Vegas Nevada, 89106, United States
East Orange New Jersey, 07018, United States
Hackensack New Jersey, 07601, United States
New Brunswick New Jersey, 08901, United States
Albany New York, 12208, United States
Bronx New York, 10461, United States
Brooklyn New York, 11209, United States
New York New York, 10010, United States
New York New York, 10016, United States
Rochester New York, 14642, United States
Fargo North Dakota, 58122, United States
Cleveland Ohio, 44106, United States
Cleveland Ohio, 44106, United States
Columbus Ohio, 43206, United States
Toledo Ohio, 43623, United States
Tulsa Oklahoma, 74136, United States
Danville Pennsylvania, 17822, United States
Philadelphia Pennsylvania, 19102, United States
Philadelphia Pennsylvania, 19104, United States
Philadelphia Pennsylvania, 19107, United States
Philadelphia Pennsylvania, 19111, United States
Pittsburgh Pennsylvania, 15213, United States
Pittsburgh Pennsylvania, 15240, United States
Wynnewood Pennsylvania, 19096, United States
Sioux Falls South Dakota, 57105, United States
Nashville Tennessee, 37212, United States
Nashville Tennessee, 37232, United States
Madison Wisconsin, 53705, United States
Madison Wisconsin, 53792, United States
Marshfield Wisconsin, 54449, United States
Milwaukee Wisconsin, 53226, United States
Milwaukee Wisconsin, 53295, United States
San Juan , 00927, Puerto Rico
San Juan , 00927, Puerto Rico
Pretoria , 0001, South Africa
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