Colon Cancer Clinical Trial

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Efficacy and Safety of Olaparib in Pretreated Patients With Measurable Colorectal Cancer, Stratified by Microsatellite Instability (MSI) Status

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Summary

This study is being carried out to see if the new drug, olaparib (AZD2281), can effectively and safely treat advanced large bowel cancer. The primary goal of this clinical trial is to determine whether olaparib will have a beneficial effect on the patient's cancer by causing a response and increasing the time it takes for the cancer to progress.

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Eligibility Criteria

Inclusion Criteria:

Patients will have measurable disseminated colorectal cancer that is incurable by surgery
Patients will have had tumor progression following standard combination front-line or second-line chemotherapy.
CRC patients who have relapsed or recurrent disease within six months after completing adjuvant or neoadjuvant chemotherapy

Exclusion Criteria:

Previous treatment with PARP inhibitors, including olaparib.
Patients with symptomatic, uncontrolled brain metastases.
Patients receiving any chemotherapy, radiotherapy (except for palliative reasons), within 4 weeks from the last dose prior to study entry (or a longer period depending on the defined characteristics of the agents used).
Patients who are unable to swallow orally administered medication.

Study is for people with:

Colon Cancer

Phase:

Phase 2

Estimated Enrollment:

33

Study ID:

NCT00912743

Recruitment Status:

Completed

Sponsor:

AstraZeneca

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There is 1 Location for this study

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Research Site
Los Angeles California, , United States
Research Site
Palm Springs California, , United States
Research Site
Aurora Colorado, , United States
Research Site
Newark Delaware, , United States
Research Site
New York New York, , United States
Research Site
Philadelphia Pennsylvania, , United States
Research Site
Nashville Tennessee, , United States
Research Site
Seattle Washington, , United States

How clear is this clinincal trial information?

Study is for people with:

Colon Cancer

Phase:

Phase 2

Estimated Enrollment:

33

Study ID:

NCT00912743

Recruitment Status:

Completed

Sponsor:


AstraZeneca

How clear is this clinincal trial information?

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