Esophageal Cancer Clinical Trial
An Investigational Immuno-therapy Study of Nivolumab or Placebo in Participants With Resected Esophageal or Gastroesophageal Junction Cancer
Summary
The primary purpose of this study is to determine whether immunotherapy-drugs-are-boosting-survival/" >Nivolumab will improve disease-free survival compared with placebo.
View Eligibility Criteria
Eligibility Criteria
Inclusion Criteria:
Diagnosed with Stage II/III carcinoma of the esophagus or gastroesophageal junction
Completed pre-operative chemo radiotherapy followed by surgery
Diagnosed with residual pathologic disease after being surgically rendered free of disease with negative margins following complete resection
Exclusion Criteria:
Diagnosed with cervical esophageal carcinoma
Diagnosed with Stage IV resectable disease
Did not receive concurrent chemoradiotherapy prior to surgery
Participants who have received a live/attenuated vaccine within 30 days of the first treatment
Other protocol defined Inclusion/exclusion criteria could apply
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There are 191 Locations for this study
See Locations Near You
Local Institution - 0250
Tucson Arizona, 85711, United States
Tucson Arizona, 85711, United States
Local Institution - 0026
Los Angeles California, 90033, United States
Los Angeles California, 90033, United States
Pacific Hematology Oncology Associates
San Francisco California, 94115, United States
San Francisco California, 94115, United States
Local Institution - 0068
San Francisco California, 94158, United States
San Francisco California, 94158, United States
Local Institution - 0151
Aurora Colorado, 80045, United States
Aurora Colorado, 80045, United States
Local Institution - 0247
Denver Colorado, 80218, United States
Denver Colorado, 80218, United States
Local Institution - 0054
Washington District of Columbia, 20007, United States
Washington District of Columbia, 20007, United States
Local Institution - 0113
Fort Myers Florida, 33901, United States
Fort Myers Florida, 33901, United States
Local Institution - 0131
Jacksonville Florida, 32256, United States
Jacksonville Florida, 32256, United States
Local Institution - 0226
Miami Florida, 33136, United States
Miami Florida, 33136, United States
Local Institution - 0022
Pensacola Florida, 32504, United States
Pensacola Florida, 32504, United States
Local Institution - 0114
Saint Petersburg Florida, 33705, United States
Saint Petersburg Florida, 33705, United States
Local Institution - 0153
Chicago Illinois, 60637, United States
Chicago Illinois, 60637, United States
Local Institution - 0025
Baltimore Maryland, 21202, United States
Baltimore Maryland, 21202, United States
Local Institution - 0055
Boston Massachusetts, 02215, United States
Boston Massachusetts, 02215, United States
Local Institution - 0170
Boston Massachusetts, 02215, United States
Boston Massachusetts, 02215, United States
Local Institution - 0171
Boston Massachusetts, 02215, United States
Boston Massachusetts, 02215, United States
Local Institution - 0217
Boston Massachusetts, 02215, United States
Boston Massachusetts, 02215, United States
Local Institution - 0027
Saint Louis Missouri, 63110, United States
Saint Louis Missouri, 63110, United States
Local Institution - 0058
Hackensack New Jersey, 07601, United States
Hackensack New Jersey, 07601, United States
Local Institution - 0066
Neptune New Jersey, 07753, United States
Neptune New Jersey, 07753, United States
Local Institution - 0205
Bronx New York, 10461, United States
Bronx New York, 10461, United States
Local Institution - 0032
New York New York, 10016, United States
New York New York, 10016, United States
Local Institution - 0033
Charlotte North Carolina, 28262, United States
Charlotte North Carolina, 28262, United States
Local Institution - 0024
Durham North Carolina, 27710, United States
Durham North Carolina, 27710, United States
Local Institution - 0056
Cleveland Ohio, 44106, United States
Cleveland Ohio, 44106, United States
Local Institution - 0165
Portland Oregon, 97239, United States
Portland Oregon, 97239, United States
Local Institution - 0101
Allentown Pennsylvania, 18103, United States
Allentown Pennsylvania, 18103, United States
Local Institution - 0048
Philadelphia Pennsylvania, 19111, United States
Philadelphia Pennsylvania, 19111, United States
Local Institution - 0116
Pittsburgh Pennsylvania, 15224, United States
Pittsburgh Pennsylvania, 15224, United States
Local Institution - 0111
Nashville Tennessee, 37203, United States
Nashville Tennessee, 37203, United States
Local Institution - 0130
Nashville Tennessee, 37232, United States
Nashville Tennessee, 37232, United States
Local Institution - 0216
Dallas Texas, 75216, United States
Dallas Texas, 75216, United States
Local Institution - 0248
Dallas Texas, 75246, United States
Dallas Texas, 75246, United States
Local Institution - 0012
Houston Texas, 77030, United States
Houston Texas, 77030, United States
Local Institution - 0241
Seattle Washington, 98101, United States
Seattle Washington, 98101, United States
Local Institution - 0067
Seattle Washington, 98109, United States
Seattle Washington, 98109, United States
Local Institution - 0069
Madison Wisconsin, 53792, United States
Madison Wisconsin, 53792, United States
Local Institution - 0050
Capital Federal Buenos Aires, 1264, Argentina
Capital Federal Buenos Aires, 1264, Argentina
Local Institution - 0152
Capital Federal Buenos Aires, 1280, Argentina
Capital Federal Buenos Aires, 1280, Argentina
Local Institution - 0164
Ciudad Autonoma Buenos Aires Distrito Federal, 1118, Argentina
Ciudad Autonoma Buenos Aires Distrito Federal, 1118, Argentina
Local Institution - 0207
Viedma RIO Negro, 8500, Argentina
Viedma RIO Negro, 8500, Argentina
Local Institution - 0208
Rosario Santa FE, 2000, Argentina
Rosario Santa FE, 2000, Argentina
Local Institution - 0051
San Miguel De Tucuman Tucuman, 4000, Argentina
San Miguel De Tucuman Tucuman, 4000, Argentina
Local Institution - 0198
Buenos Aires , 1093 , Argentina
Buenos Aires , 1093 , Argentina
Local Institution - 0133
Caba , 1426, Argentina
Caba , 1426, Argentina
Local Institution - 0112
Cordoba , X5006, Argentina
Cordoba , X5006, Argentina
Local Institution - 0200
Blacktown New South Wales, 2148, Australia
Blacktown New South Wales, 2148, Australia
Local Institution - 0098
Gosford New South Wales, 2250, Australia
Gosford New South Wales, 2250, Australia
Local Institution - 0074
St Leonards New South Wales, 2065, Australia
St Leonards New South Wales, 2065, Australia
Local Institution - 0075
Tamworth New South Wales, 2340, Australia
Tamworth New South Wales, 2340, Australia
Local Institution - 0237
Brisbane Queensland, 4102, Australia
Brisbane Queensland, 4102, Australia
Local Institution - 0123
Adelaide South Australia, 5000, Australia
Adelaide South Australia, 5000, Australia
Local Institution - 0072
Clayton Victoria, 3168, Australia
Clayton Victoria, 3168, Australia
Local Institution - 0156
Perth Western Australia, 6150, Australia
Perth Western Australia, 6150, Australia
Local Institution - 0099
Hobart , 7000, Australia
Hobart , 7000, Australia
Local Institution - 0035
Bruxelles , 1200, Belgium
Bruxelles , 1200, Belgium
Local Institution - 0037
Edegem , 2650, Belgium
Edegem , 2650, Belgium
Local Institution - 0086
Gent , 9000, Belgium
Gent , 9000, Belgium
Local Institution - 0034
Leuven , 3000, Belgium
Leuven , 3000, Belgium
Local Institution - 0036
Liege , 4000, Belgium
Liege , 4000, Belgium
Local Institution - 0087
Namur , 5000, Belgium
Namur , 5000, Belgium
Local Institution - 0095
Brasilia Distrito Federal, 70200, Brazil
Brasilia Distrito Federal, 70200, Brazil
Local Institution - 0096
Belo Horizonte Minas Gerais, 30130, Brazil
Belo Horizonte Minas Gerais, 30130, Brazil
Local Institution - 0221
Curitiba Parana, 81520, Brazil
Curitiba Parana, 81520, Brazil
Local Institution - 0059
Ijui RIO Grande DO SUL, 98700, Brazil
Ijui RIO Grande DO SUL, 98700, Brazil
Local Institution - 0060
Porto Alegre RIO Grande DO SUL, 90610, Brazil
Porto Alegre RIO Grande DO SUL, 90610, Brazil
Local Institution - 0223
Itacorubi, Florianopolis Santa Catarina, 88034, Brazil
Itacorubi, Florianopolis Santa Catarina, 88034, Brazil
Local Institution - 0061
Barretos Sao Paulo, 14780, Brazil
Barretos Sao Paulo, 14780, Brazil
Local Institution - 0222
Sao Jose De Rio Preto Sao Paulo, 15091, Brazil
Sao Jose De Rio Preto Sao Paulo, 15091, Brazil
Local Institution - 0065
Rio de Janeiro , 22793, Brazil
Rio de Janeiro , 22793, Brazil
Local Institution - 0064
Salvador , 0, Brazil
Salvador , 0, Brazil
Local Institution - 0062
Sao Paulo , 01246, Brazil
Sao Paulo , 01246, Brazil
Local Institution - 0063
Sao Paulo , 01308, Brazil
Sao Paulo , 01308, Brazil
Local Institution - 0129
Edmonton Alberta, T6G 1, Canada
Edmonton Alberta, T6G 1, Canada
Local Institution - 0093
Vancouver British Columbia, V5Z 4, Canada
Vancouver British Columbia, V5Z 4, Canada
Local Institution - 0092
Halifax Nova Scotia, B3H 1, Canada
Halifax Nova Scotia, B3H 1, Canada
Local Institution - 0094
London Ontario, N6A 4, Canada
London Ontario, N6A 4, Canada
Local Institution - 0091
Ottawa Ontario, K1H 8, Canada
Ottawa Ontario, K1H 8, Canada
Local Institution - 0110
Toronto Ontario, M5G 2, Canada
Toronto Ontario, M5G 2, Canada
Local Institution - 0134
Montreal Quebec, H4A 3, Canada
Montreal Quebec, H4A 3, Canada
Local Institution - 0214
Trois-Rivieres Quebec, G8Z 3, Canada
Trois-Rivieres Quebec, G8Z 3, Canada
Local Institution - 0109
Quebec , G1R 2, Canada
Quebec , G1R 2, Canada
Local Institution - 0240
Beijing Beijing, 10014, China
Beijing Beijing, 10014, China
Local Institution - 0234
Fuzhou Fujian, 35001, China
Fuzhou Fujian, 35001, China
Local Institution - 0227
Shanghai Shanghai, 20003, China
Shanghai Shanghai, 20003, China
Local Institution - 0239
Shanghai Shanghai, 20003, China
Shanghai Shanghai, 20003, China
Local Institution - 0230
Hangzhou Zhejiang, 31000, China
Hangzhou Zhejiang, 31000, China
Local Institution - 0238
Hangzhou Zhejiang, 31002, China
Hangzhou Zhejiang, 31002, China
Local Institution - 0233
Linhai Zhejiang, 31700, China
Linhai Zhejiang, 31700, China
Local Institution - 0232
Shanghai , 20003, China
Shanghai , 20003, China
Local Institution - 0228
Tianjin , 30006, China
Tianjin , 30006, China
Local Institution - 0031
Brno , 656 5, Czechia
Brno , 656 5, Czechia
Local Institution - 0029
Hradec Kralove , 500 0, Czechia
Hradec Kralove , 500 0, Czechia
Local Institution - 0030
Olomouc , 779 0, Czechia
Olomouc , 779 0, Czechia
Local Institution - 0166
Aarhus N , 8200, Denmark
Aarhus N , 8200, Denmark
Local Institution - 0215
Avignon Cedes 9 , 84918, France
Avignon Cedes 9 , 84918, France
Local Institution - 0121
Dijon Cedex , 21079, France
Dijon Cedex , 21079, France
Local Institution - 0117
Lille , 59037, France
Lille , 59037, France
Local Institution - 0119
Paris , 75012, France
Paris , 75012, France
Local Institution - 0120
Pessac , 33604, France
Pessac , 33604, France
Local Institution - 0118
Pierre Benite Cedex , 69495, France
Pierre Benite Cedex , 69495, France
Local Institution - 0132
Rennes Cedex 9 , 35033, France
Rennes Cedex 9 , 35033, France
Local Institution - 0149
Rouen , 76000, France
Rouen , 76000, France
Local Institution - 0148
Toulouse , 31403, France
Toulouse , 31403, France
Local Institution - 0001
Mainz Rheinland-Pfalz, 55131, Germany
Mainz Rheinland-Pfalz, 55131, Germany
Local Institution - 0006
Berlin , 13353, Germany
Berlin , 13353, Germany
Local Institution - 0008
Essen , 45136, Germany
Essen , 45136, Germany
Local Institution - 0007
Hamburg , 20251, Germany
Hamburg , 20251, Germany
Local Institution - 0003
Koeln , 50937, Germany
Koeln , 50937, Germany
Local Institution - 0017
Marburg , 35043, Germany
Marburg , 35043, Germany
Local Institution - 0005
Munich , 81675, Germany
Munich , 81675, Germany
Local Institution - 0011
Tuebingen , 72076, Germany
Tuebingen , 72076, Germany
Local Institution - 0225
Hong Kong , 0, Hong Kong
Hong Kong , 0, Hong Kong
Local Institution - 0053
Budapest , 1097, Hungary
Budapest , 1097, Hungary
Local Institution - 0224
Budapest , 1122, Hungary
Budapest , 1122, Hungary
Local Institution - 0052
Debrecen , 0, Hungary
Debrecen , 0, Hungary
Local Institution - 0057
Kaposvar , 7400, Hungary
Kaposvar , 7400, Hungary
Local Institution - 0039
Wilton Cork, 0, Ireland
Wilton Cork, 0, Ireland
Local Institution - 0040
Dublin , 9, Ireland
Dublin , 9, Ireland
Local Institution - 0038
Galway , , Ireland
Galway , , Ireland
Local Institution - 0146
Haifa , 31096, Israel
Haifa , 31096, Israel
Local Institution - 0144
Jerusalem , 91120, Israel
Jerusalem , 91120, Israel
Local Institution - 0143
Petach Tikva , 49100, Israel
Petach Tikva , 49100, Israel
Local Institution - 0145
Ramat-gan , 52621, Israel
Ramat-gan , 52621, Israel
Local Institution - 0142
Tel Aviv , 64239, Israel
Tel Aviv , 64239, Israel
Local Institution - 0105
Bergamo , 24127, Italy
Bergamo , 24127, Italy
Local Institution - 0137
Milano , 20097, Italy
Milano , 20097, Italy
Local Institution - 0104
Milano , 20133, Italy
Milano , 20133, Italy
Local Institution - 0106
Reggio Emilia , 42100, Italy
Reggio Emilia , 42100, Italy
Local Institution - 0107
Roma , 00168, Italy
Roma , 00168, Italy
Local Institution - 0173
Akita-Shi Akita, 01085, Japan
Akita-Shi Akita, 01085, Japan
Local Institution - 0180
Chiba-shi Chiba, 26086, Japan
Chiba-shi Chiba, 26086, Japan
Local Institution - 0187
Fukuoka-shi Fukuoka, 81285, Japan
Fukuoka-shi Fukuoka, 81285, Japan
Local Institution - 0189
Gifu-shi Gifu, 50111, Japan
Gifu-shi Gifu, 50111, Japan
Local Institution - 0183
Hiroshima-Shi Hiroshima, 73485, Japan
Hiroshima-Shi Hiroshima, 73485, Japan
Local Institution - 0192
Sapporo-shi Hokkaido, 00300, Japan
Sapporo-shi Hokkaido, 00300, Japan
Local Institution - 0196
Sapporo-shi Hokkaido, 06086, Japan
Sapporo-shi Hokkaido, 06086, Japan
Local Institution - 0191
Kagoshima-shi Kagoshima, 89085, Japan
Kagoshima-shi Kagoshima, 89085, Japan
Local Institution - 0184
Kumamoto-shi Kumamoto, 86085, Japan
Kumamoto-shi Kumamoto, 86085, Japan
Local Institution - 0188
Sendai-shi Miyagi, 98085, Japan
Sendai-shi Miyagi, 98085, Japan
Local Institution - 0182
Osakasayama Osaka, 589-8, Japan
Osakasayama Osaka, 589-8, Japan
Local Institution - 0185
Suita-shi Osaka, 565-0, Japan
Suita-shi Osaka, 565-0, Japan
Local Institution - 0186
Kitaadachi-gun Saitama, 36208, Japan
Kitaadachi-gun Saitama, 36208, Japan
Local Institution - 0172
Chuo-ku Tokyo, 10400, Japan
Chuo-ku Tokyo, 10400, Japan
Local Institution - 0190
Koto-ku Tokyo, 13585, Japan
Koto-ku Tokyo, 13585, Japan
Local Institution - 0174
Minato-ku Tokyo, 10584, Japan
Minato-ku Tokyo, 10584, Japan
Local Institution - 0193
Shinjuku-ku Tokyo, 16000, Japan
Shinjuku-ku Tokyo, 16000, Japan
Local Institution - 0204
Shinjuuku-ku Tokyo, 16085, Japan
Shinjuuku-ku Tokyo, 16085, Japan
Local Institution - 0194
Fukuoka , 81113, Japan
Fukuoka , 81113, Japan
Local Institution - 0181
Kita-gun , 76107, Japan
Kita-gun , 76107, Japan
Local Institution - 0175
Seoul , 05505, Korea, Republic of
Seoul , 05505, Korea, Republic of
Local Institution - 0176
Seoul , 120-7, Korea, Republic of
Seoul , 120-7, Korea, Republic of
Local Institution - 0212
Tuxtla Gutierrez Chiapas, 29038, Mexico
Tuxtla Gutierrez Chiapas, 29038, Mexico
Local Institution - 0085
Tlalpan Distrito Federal C.p., 14000, Mexico
Tlalpan Distrito Federal C.p., 14000, Mexico
Local Institution - 0127
Leon, Guanajato Guanajuato, 37000, Mexico
Leon, Guanajato Guanajuato, 37000, Mexico
Local Institution - 0154
Aguascalientes , 20230, Mexico
Aguascalientes , 20230, Mexico
Local Institution - 0168
Ciudad de Mexico , 06760, Mexico
Ciudad de Mexico , 06760, Mexico
Local Institution - 0084
Distrito Federal , 14080, Mexico
Distrito Federal , 14080, Mexico
Local Institution - 0089
Amsterdam , 1066 , Netherlands
Amsterdam , 1066 , Netherlands
Local Institution - 0042
Groningen , 9713 , Netherlands
Groningen , 9713 , Netherlands
Local Institution - 0043
Maastrict , 6229 , Netherlands
Maastrict , 6229 , Netherlands
Local Institution - 0195
Callao , 02, Peru
Callao , 02, Peru
Local Institution - 0162
Lima , 34, Peru
Lima , 34, Peru
Local Institution - 0141
Lima , LIMA , Peru
Lima , LIMA , Peru
Local Institution - 0088
Lima , LIMA , Peru
Lima , LIMA , Peru
Local Institution - 0082
Poznan Wielkopolskie, 60-78, Poland
Poznan Wielkopolskie, 60-78, Poland
Local Institution - 0083
Gliwice , 44-10, Poland
Gliwice , 44-10, Poland
Local Institution - 0138
Krakow , 31-20, Poland
Krakow , 31-20, Poland
Local Institution - 0139
Lublin , 20-08, Poland
Lublin , 20-08, Poland
Local Institution - 0081
Warszawa , 02-78, Poland
Warszawa , 02-78, Poland
Local Institution - 0097
San Juan , 00927, Puerto Rico
San Juan , 00927, Puerto Rico
Local Institution - 0167
Baia Mare , 43029, Romania
Baia Mare , 43029, Romania
Local Institution - 0163
Bucharest , 02232, Romania
Bucharest , 02232, Romania
Local Institution - 0197
Bucuresti , 02138, Romania
Bucuresti , 02138, Romania
Local Institution - 0103
Cluj-napoca , 40035, Romania
Cluj-napoca , 40035, Romania
Local Institution - 0028
Craiova , 20034, Romania
Craiova , 20034, Romania
Local Institution - 0135
Floresti , 40728, Romania
Floresti , 40728, Romania
Local Institution - 0213
Cheboksary , 42802, Russian Federation
Cheboksary , 42802, Russian Federation
Local Institution - 0125
Moscow , 11547, Russian Federation
Moscow , 11547, Russian Federation
Local Institution - 0209
Saint-Petersburg , 19702, Russian Federation
Saint-Petersburg , 19702, Russian Federation
Local Institution - 0136
St. Petersburg , 19775, Russian Federation
St. Petersburg , 19775, Russian Federation
Local Institution - 0218
Singapore , 11922, Singapore
Singapore , 11922, Singapore
Local Institution - 0219
Singapore , 16961, Singapore
Singapore , 16961, Singapore
Local Institution - 0078
Barcelona , 08035, Spain
Barcelona , 08035, Spain
Local Institution - 0079
Cordoba , 14004, Spain
Cordoba , 14004, Spain
Local Institution - 0080
Madrid , 28007, Spain
Madrid , 28007, Spain
Local Institution - 0077
Madrid , 28050, Spain
Madrid , 28050, Spain
Local Institution - 0018
Basel , 4031, Switzerland
Basel , 4031, Switzerland
Local Institution - 0047
St Gallen , 9007, Switzerland
St Gallen , 9007, Switzerland
Local Institution - 0177
Taichung , 40447, Taiwan
Taichung , 40447, Taiwan
Local Institution - 0178
Tainan , 70403, Taiwan
Tainan , 70403, Taiwan
Local Institution - 0179
Taipei , 100, Taiwan
Taipei , 100, Taiwan
Local Institution - 0160
Adana , 01250, Turkey
Adana , 01250, Turkey
Local Institution - 0161
Erzurum , 25240, Turkey
Erzurum , 25240, Turkey
Local Institution - 0157
Istanbul , 34300, Turkey
Istanbul , 34300, Turkey
Local Institution - 0203
London Greater London, NW1 2, United Kingdom
London Greater London, NW1 2, United Kingdom
Local Institution - 0045
London Greater London, SW3 6, United Kingdom
London Greater London, SW3 6, United Kingdom
Local Institution - 0046
Southampton Hampshire, SO16 , United Kingdom
Southampton Hampshire, SO16 , United Kingdom
Local Institution - 0049
Withington Manchester, M20 4, United Kingdom
Withington Manchester, M20 4, United Kingdom
Local Institution - 0169
Sutton Surrey, SM2 5, United Kingdom
Sutton Surrey, SM2 5, United Kingdom
Local Institution - 0243
Cardiff , CF14 , United Kingdom
Cardiff , CF14 , United Kingdom
Local Institution - 0202
London , SE1 9, United Kingdom
London , SE1 9, United Kingdom
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