Esophageal Cancer Clinical Trial

Gastrointestinal Biomarkers in Tissue and Biological Fluid Samples From Patients and Healthy Participants

Summary

RATIONALE: Studying samples of tissue, blood, urine, stool, and other biological fluids from patients with cancer and from healthy participants may help doctors identify and learn more about biomarkers related to cancer.

PURPOSE: This research study is looking at gastrointestinal biomarkers in tissue and biological fluid samples from patients and healthy participants undergoing colonoscopy, endoscopy, or surgery.

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Full Description

OBJECTIVES:

Identify new potential biomarkers of increased gastrointestinal cancer risk using tissue and biofluid samples from patients and healthy volunteers undergoing colonoscopy, endoscopy, or surgery.
Develop new screening strategies based on substances found in tissue and biofluid samples.

OUTLINE: This is a multicenter study.

Patients and healthy volunteers undergo colonoscopy, endoscopy, or surgery. Patients and healthy volunteers also undergo tissue (e.g., tumor or normal mucosa) and biofluid (e.g., blood, urine, cyst fluids or tumor cells, bile and pancreatic juices, and/or stool) sample collection. Samples are analyzed for tumor markers by proteomic methods and protein analysis. If candidate biomarkers are identified, samples are stored for future studies involving these biomarkers. Information, including demographics, personal and family history of cancer, and prior and current colonoscopy, endoscopy, or surgery results, is collected from the medical record and stored in the project database.

Patients and healthy volunteers are followed once a year for up to 5 years to determine if biomarkers have a prognostic significance.

View Eligibility Criteria

Eligibility Criteria

DISEASE CHARACTERISTICS:

Meets 1 of the following criteria:

Diagnosis of gastrointestinal (GI) cancer, polyps, or inflammatory bowel disease
History of previously treated GI cancer, polyps, or inflammatory bowel disease
Healthy volunteer
Undergoing colonoscopy or endoscopy for diagnostic or screening purposes at the Vanderbilt University Medical Center or at the Veterans Affairs Medical Center

PATIENT CHARACTERISTICS:

Hemoglobin ≥ 8.0 g/dL
Not pregnant
Fertile participants must use effective contraception
Capable of giving informed consent
Not mentally or medically impaired
No bleeding disorder

PRIOR CONCURRENT THERAPY:

See Disease Characteristics

Study is for people with:

Esophageal Cancer

Estimated Enrollment:

1000

Study ID:

NCT00899626

Recruitment Status:

Recruiting

Sponsor:

Vanderbilt University Medical Center

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There are 3 Locations for this study

See Locations Near You

Vanderbilt-Ingram Cancer Center - Cool Springs
Nashville Tennessee, 37064, United States More Info
Robert D Beauchamp, MD
Contact
615-322-2391
[email protected]
Vanderbilt-Ingram Cancer Center at Franklin
Nashville Tennessee, 37064, United States More Info
Robert D Beauchamp, MD
Contact
615-322-2391
[email protected]
Veterans Affairs Medical Center - Nashville
Nashville Tennessee, 37212, United States More Info
Clinical Trials Office - Veterans Affairs Medical Center - Nas
Contact
615-327-4751
Vanderbilt-Ingram Cancer Center
Nashville Tennessee, 37232, United States More Info
Clinical Trials Office - Vanderbilt-Ingram Cancer Center
Contact
800-811-8480

How clear is this clinincal trial information?

Study is for people with:

Esophageal Cancer

Estimated Enrollment:

1000

Study ID:

NCT00899626

Recruitment Status:

Recruiting

Sponsor:


Vanderbilt University Medical Center

How clear is this clinincal trial information?

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