Esophageal Cancer Clinical Trial

Paclitaxel With or Without Cixutumumab as Second-Line Therapy in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer

Summary

This randomized phase II trial studies how well paclitaxel with or without cixutumumab works in treating patients with esophageal cancer or gastroesophageal junction cancer that has spread to other places in the body (metastatic). Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Cixutumumab may kill cancer cells by blocking the action of a protein needed for cancer cell growth. Giving paclitaxel with or without cixutumumab may kill more tumor cells.

View Full Description

Full Description

PRIMARY OBJECTIVES:

I. To evaluate the progression-free survival of paclitaxel plus cixutumumab (IMC-A12) versus paclitaxel alone as second-line therapy in patients with metastatic esophagus or gastroesophageal (GE) junction cancer.

SECONDARY OBJECTIVES:

I. To evaluate the overall survival of paclitaxel plus cixutumumab (IMC-A12) versus paclitaxel alone in this patient population.

II. To evaluate the response rate of paclitaxel plus cixutumumab (IMC-A12) versus paclitaxel alone in this patient population.

III. To evaluate the toxicity of cixutumumab (IMC-A12) plus paclitaxel versus paclitaxel alone in this patient population.

IV. Exploratory analyses will assess potentially relevant cixutumumab (IMC-A12) pharmacodynamic biomarkers obtained from serum samples, including but not limited to, insulin-like growth factor (IGF)-I, IGF-II, insulin-like growth factor binding protein (IGFBP)-2, and IGFBP-3.

OUTLINE: Patients are equally randomized to 1 of 2 treatment arms.

ARM I: Patients receive paclitaxel intravenously (IV) over 1 hour at a dose of 80 mg/m^2 on days 1, 8, and 15 of every 28 day cycle.

ARM II: Patients receive cixutumumab IV over 1 hour at a dose of 10 mg/kg on days 1 and 15 of every 28 day cycle and paclitaxel as in Arm I.

In both arms, courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Life expectancy >= 12 weeks
Women must not be pregnant or breast-feeding due to potential harm to fetus from cixutumumab (IMC-A12) and paclitaxel; all females of childbearing potential must have a blood test or urine study within 48 hours prior to registration to rule out pregnancy
Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method or birth control; abstinence) for the duration of study therapy and for 3 months after the last dose of cixutumumab (IMC-A12); should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately
Patients must have measurable disease

Patients must have metastatic disease of the esophagus or gastroesophageal junction

Histologic, cytologic or radiologic documentation of metastatic squamous cell carcinoma or adenocarcinoma of the esophagus or gastroesophageal junction; radiologic, endoscopic, histologic or cytologic evidence of locally recurrent or locally residual (post-resection) disease is also permitted
For the purposes of this study, undifferentiated adenocarcinomas and adenosquamous tumors will be considered as adenocarcinomas; in addition, tumors involving the gastroesophageal junction will be defined by the Siewert classification

Patients with gastroesophageal junction tumors who are eligible:

Adenocarcinoma of the esophageal junction (AEG) Type I: adenocarcinoma of the distal esophagus which usually arises from an area with specialized intestinal metaplasia of the esophagus, i.e., Barrett's esophagus, and may infiltrate the esophagogastric junction from above
AEG Type II: true carcinoma of the cardia arising from the cardiac epithelium or short segments with intestinal metaplasia at the esophagogastric junction

Patients with gastroesophageal junction tumors who are NOT eligible:

AEG Type III: subcardial gastric carcinoma which infiltrates the esophagogastric junction and distal esophagus from below

Patients must have received and progressed on one and only one line of prior systemic therapy for esophagus or esophagogastric cancer; this could have included one regimen for metastatic disease, or one regimen with radiotherapy for initially locally advanced disease; prior radiation therapy is permitted

If patients progress or recur within 6 months of neoadjuvant/adjuvant therapy, this will be considered one line of therapy; for patients progressing or recurring more than 6 months after neoadjuvant/adjuvant therapy, they will need to receive one line of therapy for recurrent disease to be eligible
If patients receive one regimen in which a chemotherapy agent is dropped for toxicity without progression, this treatment will be considered one line of therapy; however, substitution or addition of a new agent will be considered a second line of therapy
Eastern Cooperative Oncology Group (ECOG) performance status 0-2
Leukocytes > 3,000/mcL
Absolute neutrophil count >= 1,500/mcL
Hemoglobin >= 9 g/dL
Platelets >= 100,000/mcL
Total bilirubin =< institutional upper limit of normal (ULN)
Aspartate transaminase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine transaminase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 3 X institutional ULN
Creatinine =< 1.5 X institutional ULN or creatinine clearance >= 60 mL/min/1.73m^2 for patients with creatinine levels above institutional normal
Patients must have fasting serum glucose =< 160 mg/dL (8.8 mmol/L) or =< ULN, and hemoglobin A1C =< 7% (0.07 International System of Units [SI units]) within 14 days of registration; if baseline nonfasting glucose =< 160 mg/dL (8.8 mmol/L), fasting glucose measurement is not required
Registration no fewer than 28 days from last chemotherapy
A "currently active" second malignancy other than non-melanoma skin cancers are not to be registered; patients are not considered to have a "currently active" malignancy if they have completed therapy and are considered by their physician to be at less than 30% risk of relapse

Exclusion Criteria:

Patients have received prior taxane or anti-insulin growth factor receptor (IGFR) therapy

Patients must not have any of the following conditions:

Poorly controlled diabetes mellitus; patients with a history of diabetes mellitus are allowed to participate, provided that their blood glucose is within normal range (fasting glucose =< 160 mg/dL [8.8 mmol/L] or below the ULN and hemoglobin A1C =< 7% [0.07 SI units]) and that they are on a stable dietary or therapeutic regimen for this condition
Recent major surgery, hormonal therapy (other than replacement) or chemotherapy, within 4 weeks prior to entering the study or those who have not recovered from adverse events
History of allergic reactions attributed to compounds of similar chemical or biologic composition to cixutumumab (IMC-A12)
Psychiatric illness that would prevent the patient from giving informed consent
Medical conditions such as active/uncontrolled infection (including HIV) or cardiac disease that would make this protocol unreasonably hazardous for the patient in the opinion of the treating physician; cardiac disease may include uncontrolled high blood pressure, unstable angina, or serious uncontrolled cardiac arrhythmia

Study is for people with:

Esophageal Cancer

Phase:

Phase 2

Estimated Enrollment:

94

Study ID:

NCT01142388

Recruitment Status:

Active, not recruiting

Sponsor:

National Cancer Institute (NCI)

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There are 205 Locations for this study

See Locations Near You

Mayo Clinic in Arizona
Scottsdale Arizona, 85259, United States
Stanford Cancer Institute Palo Alto
Palo Alto California, 94304, United States
The Medical Center of Aurora
Aurora Colorado, 80012, United States
Boulder Community Hospital
Boulder Colorado, 80301, United States
Penrose-Saint Francis Healthcare
Colorado Springs Colorado, 80907, United States
Porter Adventist Hospital
Denver Colorado, 80210, United States
Presbyterian - Saint Lukes Medical Center - Health One
Denver Colorado, 80218, United States
SCL Health Saint Joseph Hospital
Denver Colorado, 80218, United States
Rose Medical Center
Denver Colorado, 80220, United States
Western States Cancer Research NCORP
Denver Colorado, 80222, United States
Swedish Medical Center
Englewood Colorado, 80113, United States
Saint Mary's Hospital and Regional Medical Center
Grand Junction Colorado, 81501, United States
North Colorado Medical Center
Greeley Colorado, 80631, United States
Saint Anthony Hospital
Lakewood Colorado, 80228, United States
Littleton Adventist Hospital
Littleton Colorado, 80122, United States
Sky Ridge Medical Center
Lone Tree Colorado, 80124, United States
Longmont United Hospital
Longmont Colorado, 80501, United States
McKee Medical Center
Loveland Colorado, 80539, United States
Parker Adventist Hospital
Parker Colorado, 80138, United States
Saint Mary Corwin Medical Center
Pueblo Colorado, 81004, United States
North Suburban Medical Center
Thornton Colorado, 80229, United States
SCL Health Lutheran Medical Center
Wheat Ridge Colorado, 80033, United States
Smilow Cancer Hospital Care Center at Saint Francis
Hartford Connecticut, 06105, United States
Beebe Medical Center
Lewes Delaware, 19958, United States
Christiana Care Health System-Christiana Hospital
Newark Delaware, 19718, United States
Mayo Clinic in Florida
Jacksonville Florida, 32224, United States
Emory University Hospital/Winship Cancer Institute
Atlanta Georgia, 30322, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah Georgia, 31405, United States
Saint Alphonsus Cancer Care Center-Boise
Boise Idaho, 83706, United States
Rush - Copley Medical Center
Aurora Illinois, 60504, United States
MacNeal Hospital and Cancer Center
Berwyn Illinois, 60402, United States
Saint Joseph Medical Center
Bloomington Illinois, 61701, United States
Graham Hospital Association
Canton Illinois, 61520, United States
Memorial Hospital
Carthage Illinois, 62321, United States
Hematology and Oncology Associates
Chicago Illinois, 60611, United States
Northwestern University
Chicago Illinois, 60611, United States
Decatur Memorial Hospital
Decatur Illinois, 62526, United States
Heartland Cancer Research NCORP
Decatur Illinois, 62526, United States
Eureka Hospital
Eureka Illinois, 61530, United States
Illinois CancerCare-Galesburg
Galesburg Illinois, 61401, United States
Ingalls Memorial Hospital
Harvey Illinois, 60426, United States
Mason District Hospital
Havana Illinois, 62644, United States
Hematology Oncology Associates of Illinois-Highland Park
Highland Park Illinois, 60035, United States
Hinsdale Hematology Oncology Associates Incorporated
Hinsdale Illinois, 60521, United States
Duly Health and Care Joliet
Joliet Illinois, 60435, United States
Presence Saint Mary's Hospital
Kankakee Illinois, 60901, United States
AMG Libertyville - Oncology
Libertyville Illinois, 60048, United States
Mcdonough District Hospital
Macomb Illinois, 61455, United States
Trinity Medical Center
Moline Illinois, 61265, United States
DuPage Medical Group-Ogden
Naperville Illinois, 60563, United States
Illinois Cancer Specialists-Niles
Niles Illinois, 60714, United States
Bromenn Regional Medical Center
Normal Illinois, 61761, United States
Carle Cancer Institute Normal
Normal Illinois, 61761, United States
Ottawa Regional Hospital and Healthcare Center
Ottawa Illinois, 61350, United States
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Pekin Illinois, 61554, United States
Proctor Hospital
Peoria Illinois, 61614, United States
Illinois CancerCare-Peoria
Peoria Illinois, 61615, United States
Methodist Medical Center of Illinois
Peoria Illinois, 61636, United States
OSF Saint Francis Medical Center
Peoria Illinois, 61637, United States
Illinois Valley Hospital
Peru Illinois, 61354, United States
Perry Memorial Hospital
Princeton Illinois, 61356, United States
West Suburban Medical Center
River Forest Illinois, 60305, United States
Swedish American Hospital
Rockford Illinois, 61104, United States
Hematology Oncology Associates of Illinois - Skokie
Skokie Illinois, 60076, United States
Memorial Medical Center
Springfield Illinois, 62781, United States
Carle Cancer Center
Urbana Illinois, 61801, United States
Elkhart General Hospital
Elkhart Indiana, 46515, United States
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis Indiana, 46202, United States
Richard L. Roudebush Veterans Affairs Medical Center
Indianapolis Indiana, 46202, United States
Sidney and Lois Eskenazi Hospital
Indianapolis Indiana, 46202, United States
IU Health Central Indiana Cancer Centers-East
Indianapolis Indiana, 46219, United States
Community Howard Regional Health
Kokomo Indiana, 46904, United States
IU Health La Porte Hospital
La Porte Indiana, 46350, United States
Franciscan Saint Anthony Health-Michigan City
Michigan City Indiana, 46360, United States
Saint Joseph Regional Medical Center-Mishawaka
Mishawaka Indiana, 46545, United States
IU Health Ball Memorial Hospital
Muncie Indiana, 47303, United States
Memorial Hospital of South Bend
South Bend Indiana, 46601, United States
Northern Indiana Cancer Research Consortium
South Bend Indiana, 46628, United States
McFarland Clinic PC - Ames
Ames Iowa, 50010, United States
Mercy Hospital
Cedar Rapids Iowa, 52403, United States
Oncology Associates at Mercy Medical Center
Cedar Rapids Iowa, 52403, United States
Medical Oncology and Hematology Associates-West Des Moines
Clive Iowa, 50325, United States
Iowa Methodist Medical Center
Des Moines Iowa, 50309, United States
Iowa-Wide Oncology Research Coalition NCORP
Des Moines Iowa, 50309, United States
Medical Oncology and Hematology Associates-Des Moines
Des Moines Iowa, 50309, United States
Mercy Medical Center - Des Moines
Des Moines Iowa, 50314, United States
Mission Cancer and Blood - Laurel
Des Moines Iowa, 50314, United States
Iowa Lutheran Hospital
Des Moines Iowa, 50316, United States
Mercy Medical Center - North Iowa
Mason City Iowa, 50401, United States
Siouxland Regional Cancer Center
Sioux City Iowa, 51101, United States
Mercy Medical Center-Sioux City
Sioux City Iowa, 51102, United States
Saint Luke's Regional Medical Center
Sioux City Iowa, 51104, United States
Cancer Center of Kansas - Chanute
Chanute Kansas, 66720, United States
Cancer Center of Kansas - Dodge City
Dodge City Kansas, 67801, United States
Cancer Center of Kansas - El Dorado
El Dorado Kansas, 67042, United States
Cancer Center of Kansas - Fort Scott
Fort Scott Kansas, 66701, United States
Cancer Center of Kansas-Independence
Independence Kansas, 67301, United States
Cancer Center of Kansas-Kingman
Kingman Kansas, 67068, United States
Lawrence Memorial Hospital
Lawrence Kansas, 66044, United States
Cancer Center of Kansas-Liberal
Liberal Kansas, 67905, United States
Cancer Center of Kansas - McPherson
McPherson Kansas, 67460, United States
Cancer Center of Kansas - Newton
Newton Kansas, 67114, United States
Cancer Center of Kansas - Parsons
Parsons Kansas, 67357, United States
Cancer Center of Kansas - Pratt
Pratt Kansas, 67124, United States
Cancer Center of Kansas - Salina
Salina Kansas, 67401, United States
Cancer Center of Kansas - Wellington
Wellington Kansas, 67152, United States
Associates In Womens Health
Wichita Kansas, 67208, United States
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita Kansas, 67208, United States
Ascension Via Christi Hospitals Wichita
Wichita Kansas, 67214, United States
Cancer Center of Kansas - Wichita
Wichita Kansas, 67214, United States
Wichita NCI Community Oncology Research Program
Wichita Kansas, 67214, United States
Cancer Center of Kansas - Winfield
Winfield Kansas, 67156, United States
Mary Bird Perkins Cancer Center
Baton Rouge Louisiana, 70809, United States
Louisiana State University Health Science Center
New Orleans Louisiana, 70112, United States
University Medical Center New Orleans
New Orleans Louisiana, 70112, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore Maryland, 21287, United States
Christiana Care - Union Hospital
Elkton Maryland, 21921, United States
Bixby Medical Center
Adrian Michigan, 49221, United States
Hickman Cancer Center
Adrian Michigan, 49221, United States
Michigan Cancer Research Consortium NCORP
Ann Arbor Michigan, 48106, United States
Saint Joseph Mercy Hospital
Ann Arbor Michigan, 48106, United States
Beaumont Hospital - Dearborn
Dearborn Michigan, 48124, United States
Ascension Saint John Hospital
Detroit Michigan, 48236, United States
Hurley Medical Center
Flint Michigan, 48503, United States
Genesys Regional Medical Center-West Flint Campus
Flint Michigan, 48532, United States
Allegiance Health
Jackson Michigan, 49201, United States
Bronson Methodist Hospital
Kalamazoo Michigan, 49007, United States
West Michigan Cancer Center
Kalamazoo Michigan, 49007, United States
Borgess Medical Center
Kalamazoo Michigan, 49048, United States
Sparrow Hospital
Lansing Michigan, 48912, United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia Michigan, 48154, United States
Mercy Memorial Hospital
Monroe Michigan, 48162, United States
Toledo Clinic Cancer Centers-Monroe
Monroe Michigan, 48162, United States
Saint Joseph Mercy Oakland
Pontiac Michigan, 48341, United States
Lake Huron Medical Center
Port Huron Michigan, 48060, United States
Ascension Saint Mary's Hospital
Saginaw Michigan, 48601, United States
Lakeland Medical Center Saint Joseph
Saint Joseph Michigan, 49085, United States
Marie Yeager Cancer Center
Saint Joseph Michigan, 49085, United States
Saint John Macomb-Oakland Hospital
Warren Michigan, 48093, United States
Essentia Health Saint Joseph's Medical Center
Brainerd Minnesota, 56401, United States
Fairview Ridges Hospital
Burnsville Minnesota, 55337, United States
Mercy Hospital
Coon Rapids Minnesota, 55433, United States
Essentia Health Cancer Center
Duluth Minnesota, 55805, United States
Essentia Health Saint Mary's Medical Center
Duluth Minnesota, 55805, United States
Miller-Dwan Hospital
Duluth Minnesota, 55805, United States
Fairview Southdale Hospital
Edina Minnesota, 55435, United States
Unity Hospital
Fridley Minnesota, 55432, United States
Hutchinson Area Health Care
Hutchinson Minnesota, 55350, United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood Minnesota, 55109, United States
Saint John's Hospital - Healtheast
Maplewood Minnesota, 55109, United States
Abbott-Northwestern Hospital
Minneapolis Minnesota, 55407, United States
Hennepin County Medical Center
Minneapolis Minnesota, 55415, United States
New Ulm Medical Center
New Ulm Minnesota, 56073, United States
North Memorial Medical Health Center
Robbinsdale Minnesota, 55422, United States
Mayo Clinic in Rochester
Rochester Minnesota, 55905, United States
Metro Minnesota Community Oncology Research Consortium
Saint Louis Park Minnesota, 55416, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park Minnesota, 55416, United States
Regions Hospital
Saint Paul Minnesota, 55101, United States
United Hospital
Saint Paul Minnesota, 55102, United States
Saint Francis Regional Medical Center
Shakopee Minnesota, 55379, United States
Lakeview Hospital
Stillwater Minnesota, 55082, United States
Ridgeview Medical Center
Waconia Minnesota, 55387, United States
Rice Memorial Hospital
Willmar Minnesota, 56201, United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury Minnesota, 55125, United States
Nebraska Cancer Research Center
Lincoln Nebraska, 68510, United States
Missouri Valley Cancer Consortium
Omaha Nebraska, 68106, United States
Alegent Health Immanuel Medical Center
Omaha Nebraska, 68122, United States
Alegent Health Bergan Mercy Medical Center
Omaha Nebraska, 68124, United States
Alegent Health Lakeside Hospital
Omaha Nebraska, 68130, United States
Creighton University Medical Center
Omaha Nebraska, 68131, United States
Cooper Hospital University Medical Center
Camden New Jersey, 08103, United States
Veterans Adminstration New Jersey Health Care System
East Orange New Jersey, 07018, United States
CentraState Medical Center
Freehold New Jersey, 07728, United States
The Cancer Institute of New Jersey Hamilton
Hamilton New Jersey, 08690, United States
Rutgers Cancer Institute of New Jersey
New Brunswick New Jersey, 08903, United States
Rutgers New Jersey Medical School
Newark New Jersey, 07101, United States
Newark Beth Israel Medical Center
Newark New Jersey, 07112, United States
New York Oncology Hematology PC - Albany Medical Center
Albany New York, 12208, United States
Essentia Health Cancer Center-South University Clinic
Fargo North Dakota, 58103, United States
Summa Health System - Akron Campus
Akron Ohio, 44304, United States
Toledo Clinic Cancer Centers-Bowling Green
Bowling Green Ohio, 43402, United States
Cleveland Clinic Mercy Hospital
Canton Ohio, 44708, United States
MetroHealth Medical Center
Cleveland Ohio, 44109, United States
North Coast Cancer Care-Clyde
Clyde Ohio, 43410, United States
Hematology Oncology Center Incorporated
Elyria Ohio, 44035, United States
Mercy Cancer Center-Elyria
Elyria Ohio, 44035, United States
Saint Rita's Medical Center
Lima Ohio, 45801, United States
Lima Memorial Hospital
Lima Ohio, 45804, United States
Saint Luke's Hospital
Maumee Ohio, 43537, United States
Toledo Clinic Cancer Centers-Maumee
Maumee Ohio, 43537, United States
Fisher-Titus Medical Center
Norwalk Ohio, 44857, United States
Saint Charles Hospital
Oregon Ohio, 43616, United States
Toledo Clinic Cancer Centers-Oregon
Oregon Ohio, 43616, United States
North Coast Cancer Care
Sandusky Ohio, 44870, United States
ProMedica Flower Hospital
Sylvania Ohio, 43560, United States
Mercy Hospital of Tiffin
Tiffin Ohio, 44883, United States
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo Ohio, 43606, United States
Saint Vincent Mercy Medical Center
Toledo Ohio, 43608, United States
University of Toledo
Toledo Ohio, 43614, United States
Toledo Community Hospital Oncology Program CCOP
Toledo Ohio, 43617, United States
Mercy Health - Saint Anne Hospital
Toledo Ohio, 43623, United States
Toledo Clinic Cancer Centers-Toledo
Toledo Ohio, 43623, United States
Fulton County Health Center
Wauseon Ohio, 43567, United States
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem Pennsylvania, 18015, United States
Bryn Mawr Hospital
Bryn Mawr Pennsylvania, 19010, United States
Butler Memorial Hospital
Butler Pennsylvania, 16001, United States
Geisinger Medical Center
Danville Pennsylvania, 17822, United States
Geisinger Medical Center-Cancer Center Hazleton
Hazleton Pennsylvania, 18201, United States
Paoli Memorial Hospital
Paoli Pennsylvania, 19301, United States
Thomas Jefferson University Hospital
Philadelphia Pennsylvania, 19107, United States
Fox Chase Cancer Center
Philadelphia Pennsylvania, 19111, United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh Pennsylvania, 15232, United States
Pottstown Hospital
Pottstown Pennsylvania, 19464, United States
Hematology and Oncology Associates of North East Pennsylvania
Scranton Pennsylvania, 18508, United States
Geisinger Medical Group
State College Pennsylvania, 16801, United States
Reading Hospital
West Reading Pennsylvania, 19611, United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre Pennsylvania, 18711, United States
Lankenau Medical Center
Wynnewood Pennsylvania, 19096, United States
Main Line Health NCORP
Wynnewood Pennsylvania, 19096, United States
Jackson-Madison County General Hospital
Jackson Tennessee, 38301, United States
Fredericksburg Oncology Inc
Fredericksburg Virginia, 22401, United States
Wheeling Hospital/Schiffler Cancer Center
Wheeling West Virginia, 26003, United States
Langlade Hospital and Cancer Center
Antigo Wisconsin, 54409, United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay Wisconsin, 54301, United States
UW Cancer Center Johnson Creek
Johnson Creek Wisconsin, 53038, United States
Gundersen Lutheran Medical Center
La Crosse Wisconsin, 54601, United States
Dean Hematology and Oncology Clinic
Madison Wisconsin, 53717, United States
University of Wisconsin Carbone Cancer Center
Madison Wisconsin, 53792, United States
Holy Family Memorial Hospital
Manitowoc Wisconsin, 54221, United States
Bay Area Medical Center
Marinette Wisconsin, 54143, United States
HSHS Saint Nicholas Hospital
Sheboygan Wisconsin, 53081, United States
Aspirus Regional Cancer Center
Wausau Wisconsin, 54401, United States
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids Wisconsin, 54494, United States

How clear is this clinincal trial information?

Study is for people with:

Esophageal Cancer

Phase:

Phase 2

Estimated Enrollment:

94

Study ID:

NCT01142388

Recruitment Status:

Active, not recruiting

Sponsor:


National Cancer Institute (NCI)

How clear is this clinincal trial information?

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