Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers

Key Inclusion Criteria:

Must have at least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST) guidance
Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1

Monotherapy-specific criteria for dose escalation cohorts:

Participants may have any pathologically confirmed advanced or metastatic solid tumor malignancy for which standard therapy has proven ineffective, intolerable, or considered inappropriate

Disease-specific criteria for dose-expansion Cohort 1 (NSCLC):

Histologically confirmed, documented diagnosis of locally advanced unresectable or metastatic non-squamous NSCLC
Treatment-naive in the unresectable locally advanced or metastatic setting
Cannot have progressed within 6 months of prior platinum-based chemotherapy for earlier stage disease
Mixed small-cell lung cancer histology is not permitted

Disease-specific criteria for dose expansion Cohort 2 (Gastric/GEJ):

Histologically confirmed, documented diagnosis of human epidermal growth factor 2 (HER2)-negative locally advanced unresectable or metastatic gastric or GEJ adenocarcinoma
No prior systemic treatment for locally advanced unresectable or metastatic disease
Cannot have progressed within 6 months of prior platinum-based chemotherapy for earlier stage disease

Key Exclusion Criteria:

Use of any live vaccines against infectious diseases (eg, influenza, varicella) within 4 weeks (28 days) of initiation of study
Underlying medical conditions or AEs that, in the investigator's or sponsor's opinion, will make the administration of the study drugs hazardous
Any active or documented history of autoimmune disease including but not limited to inflammatory bowel disease, celiac disease, Wegner syndrome, Hashimoto syndrome, systemic lupus erythematosus, scleroderma, sarcoidosis, or autoimmune hepatitis, within 3 years of the first dose of study treatment
History of trauma or major surgery within 28 days prior to the first dose of study drug
Treatment with systemic immunosuppressive medication within 2 weeks prior to initiation of study treatment, or anticipation of need for systemic immunosuppressant medication during study treatment with certain protocol specified exceptions

Note: Other protocol defined Inclusion/Exclusion criteria may apply.