Heart Failure Clinical Trial
Beginning a Randomized Evaluation of the AGE Breaker Alagebrium in Diastolic Heart Failure (BREAK-DHF-I)
Summary
This study is being done to evaluate the safety and effectiveness of alagebrium in subjects diagnosed with diastolic heart failure. The primary assessment for effectiveness is the assessment of exercise tolerance.
Eligibility Criteria
Inclusion Criteria:
diagnosis of diabetes or hypertension requiring therapy
EF >/= 45% via echo within 1 year and evidence of diastolic heart failure via echo measurement of E/E'>/= 12 determined by echo within 1 year
previous hospitalization for heart failure or previous BNP >100 pg/mL.
Exclusion Criteria:
Clinically significant valvular disease
history of stroke/TIA or reversible ischemic neurological defect w/i 6 mths
history of acute MI within 6 months
severe COPD
active or treated malignancies (except basal cell carcinoma)
significant systemic illnesses that would prohibit completion of the study or compliance
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There are 28 Locations for this study
Birmingham Alabama, 35294, United States
Huntsville Alabama, 35801, United States
Mobile Alabama, 36608, United States
Anaheim California, , United States
Bakersfield California, 93308, United States
La Jolla California, 92037, United States
Roseville California, 95661, United States
Jacksonville Florida, 32209, United States
Miami Florida, 33136, United States
St. Petersburg Florida, 33709, United States
Covington Georgia, 30014, United States
Indianapolis Indiana, 46260, United States
Louisville Kentucky, 40207, United States
Auburn Maine, 04210, United States
South Portland Maine, 04106, United States
Ayer Massachusetts, 01432, United States
Lincoln Nebraska, 68506, United States
Ridgewood New Jersey, 07450, United States
Albany New York, 12205, United States
Stonybrook New York, 11794, United States
Winston-Salem North Carolina, 27157, United States
Cincinnati Ohio, 45219, United States
Dayton Ohio, 45414, United States
Fairfield Ohio, 45014, United States
Sandusky Ohio, 44870, United States
Oklahoma City Oklahoma, 73112, United States
Charleston South Carolina, 29401, United States
Germantown Tennessee, 38138, United States
Lackland Airforce Base Texas, , United States
Milwaukee Wisconsin, 53215, United States
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