Heart Failure Clinical Trial
Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction
Summary
This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.
Full Description
This is a prospective pilot study to evaluate changes before and 4 weeks(+/- 1 week) after beta-blocker withdrawal in 30 HFpEF patients. The study involves 2 visits that are 4 weeks apart. The first study visit will occur at a standard of care clinic visit and the second visit will be a research visit to fill out questionnaires and perform the limited echocardiogram. No long term follow up beyond the 2nd visit.
Eligibility Criteria
Inclusion Criteria:
Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100
N=30 (Target: 30).
Age: 50 ~ 80 years.
ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction.
Chronic loop diuretic use
Currently on beta-blocker
Exclusion Criteria:
Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease.
Heart rate > 100 bpm
Recent hospitalization due to HF within 3 months
Non-English speaker
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