Heart Failure Clinical Trial

Clinical Trial Finder Heart Failure Trials

Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure

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Summary

Different doses of relaxin will be compared to placebo to determine efficacy and safety for the treatment of patients hospitalized with acute heart failure

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Full Description

This is an international, randomized, double-blind, placebo-controlled, Phase II/III trial of intravenous recombinant relaxin for the treatment of signs and symptoms in patients hospitalized for acute decompensated heart failure. The Phase II pilot study has completed; the Phase III main portion of the trial is ongoing.

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Eligibility Criteria

Inclusion Criteria:

Hospitalized for acute heart failure
Dyspnea at rest or with minimal exertion
Pulmonary congestion
Able to provide informed consent
Systolic blood pressure > 125 mmHg
Impaired renal function defined as an eGFR of 30-75 mL/min/1.73m2

Exclusion Criteria:

Use of other IV therapies for acute heart failure
Fever or sepsis
Recent major neurologic event
Recent major surgery
Recent acute coronary syndrome
Other recent investigational drug use

Study is for people with:

Heart Failure

Phase:

Phase 2

Estimated Enrollment:

1161

Study ID:

NCT00520806

Recruitment Status:

Completed

Sponsor:

Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies

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There are 2 Locations for this study

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Northwestern University
Chicago Illinois, 60611, United States
Wayne State University/Detroit Receiving Hospital
Detroit Michigan, 48201, United States
Heart Institute
Safed , , Israel

How clear is this clinincal trial information?

Study is for people with:

Heart Failure

Phase:

Phase 2

Estimated Enrollment:

1161

Study ID:

NCT00520806

Recruitment Status:

Completed

Sponsor:


Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies

How clear is this clinincal trial information?

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