Heart Failure Clinical Trial

Food As Medicine for Heart Failure

Summary

Malnutrition and unintentional weight loss are highly prevalent among patients with heart failure (HF), with approximately 50% of patients with heart failure meeting malnutrition criteria. Poor dietary quality and micronutrient deficiencies are associated with higher rates of HF hospitalization and mortality. Therefore nutritional interventions to improve dietary quality and prevent malnutrition development may represent an effective strategy to improve HF-related health status and survival outcomes. To date, there are no large clinical trials investigating the efficacy of 'food as medicine' to improve morbidity and mortality for patients with heart failure with reduced ejection fraction (HFrEF). The investigators plan to conduct a single-center, randomized pilot trial to assess the tolerability, feasibility, and efficacy of providing medically-tailored meals (MTMs) or protein supplementation shakes to patients with HFrEF and malnutrition. The investigators hypothesize that home delivery of MTMs or protein supplementation shakes will be feasible, well-tolerated and achieve a high degree of satisfaction for patients with HFrEF. The current pilot phase is a single arm non-randomized study. An initial phase has delivered a 12-week MTM dietary intervention. The MTMs are designed, prepared and delivered by our community based organized partner, Community Servings. A second phase will deliver a 12-week protein supplementation shake intervention, with 1 bottle to be consumed daily in addition to the participants' standard home diet. The investigators will measure HF-related health status, functional capacity, and biomarkers of heart failure and nutritional status before and after each study phase. The proposed study will facilitate a larger future randomized trial of nutritional intervention for patients with HFrEF and malnutrition, powered to examine the impact on HF hospitalizations and mortality.

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Full Description

We plan to conduct a single-center pilot trial to assess the tolerability, feasibility, and efficacy of providing medically-tailored meals to patients with heart failure with reduced ejection fraction and malnutrition. We hypothesize that a nutritionally complete meal plan, targeting 1.1-1.5 g/kg/day protein intake, will improve symptomatology, functional capacity, and serum biomarkers of heart failure in this patient population. We have two primary objectives for this pilot study: 1) confirm tolerability, feasibility, and efficacy of prescribing MTMs or oral protein supplementation and 2) measure changes in functional capacity, patient-reported health status, and biomarkers of nutritional status and heart failure over the course of the study period. For this proposed study, we will test the following elements of this central hypothesis with 2 aims:

Aim 1 Tolerability, feasibility, and efficacy of prescribing medically-tailored meals or protein supplementation: Tolerability will be assessed with the validated 28-item dietary satisfaction score (DSat-28). Efficacy will be assessed by improvement in patient-reported health status questionnaires and feasibility will be assessed by the macronutrient intakes achieved on facilitated food recalls.

Aim 2 Functional capacity and serum biomarkers of nutrition/heart failure: Determine whether medically tailored meals improve symptomatology, functional capacity, and serum biomarkers of nutrition and heart failure in patients with advanced heart failure.

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Eligibility Criteria

Inclusion Criteria:

Systolic heart failure (left ventricular ejection fraction At least one prior hospitalization in the preceding 12 months
Evidence of malnutrition on the Short Nutritional Assessment Questionnaire (SNAQ) screening tool for malnutrition (score of 2 or more)
Have a fixed address within the Metro Boston region and availability of home refrigeration to accommodate the MTM deliveries
Able and willing to sign study consent
18 years or above
Not currently pregnant and not imminently planning a pregnancy

Exclusion Criteria:

Prior heart transplantation or implantation of a left ventricular assist device
Patients with a non-cardiac etiology for a skeletal muscle disorder e.g. muscular dystrophy, cancer
Currently pregnant or planning to become pregnant
Food allergy, aversion, or dietary preference that cannot be accommodated by Community Servings
Systolic blood pressure at screening <90 mmHg, or heart rate >110 bpm
Galactosemia

Study is for people with:

Heart Failure

Estimated Enrollment:

6

Study ID:

NCT04847973

Recruitment Status:

Completed

Sponsor:

Tufts Medical Center

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There is 1 Location for this study

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Tufts Medical Center
Boston Massachusetts, 02111, United States

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Study is for people with:

Heart Failure

Estimated Enrollment:

6

Study ID:

NCT04847973

Recruitment Status:

Completed

Sponsor:


Tufts Medical Center

How clear is this clinincal trial information?

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