Heart Failure Clinical Trial

Genomic Response Analysis of Heart Failure Therapy in African Americans

Summary

The response to therapy with a fixed dose combination of isosorbide dinitrate and hydralazine (FDC I/H) is enhanced in African Americans with heart failure and reduced ejection fraction (HFrEF) when compared to similar white cohorts. This study will seek to confirm the previous genetic sub-study from AHeFT which suggested a functional polymorphism of guanine nucleotide binding protein beta polypeptide 3 subunit (GNB3), C825T in exon 10, influences the therapeutic efficacy of FDC I/H. This study will initiate treatment with FDC I/H in 500 self designated African American subjects with systolic heart failure. They will be followed for up to two years on therapy. Clinical outcomes (survival, heart failure hospitalizations, and change in quality of life) on FDC I/H will be compared by GNB3 genotype subset. The hypothesis to be confirmed is that subjects homozygous for the T allele (those with the GNB3 TT genotype which is present in approximately 50% of black subjects) demonstrate enhanced therapeutic benefit from FDC I/H.

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Full Description

The response to therapy with a fixed dose combination of isosorbide dinitrate and hydralazine (FDC I/H) is enhanced in African Americans with heart failure and reduced ejection fraction (HFrEF) when compared to similar white cohorts. Despite the clear survival benefits of treatment with FDC I/H in the African American Heart Failure Trial (AHeFT), the drug is prescribed in only 25% of black subjects who would potentially benefit.

In terms of the enhanced response evident in the A-HeFT investigation, race is likely a marker of differences in genomic background. Genetic variation of the G protein beta sub unit GNB3 has been studied extensively for its role in hypertension. A polymorphism exists at position 825 (T/C) which is functionally silent but tightly linked to a splicing variant resulting in a truncated protein. The GNB3 T haplotype is far more prevalent in blacks and associated with low renin hypertension. Evaluation of 350 subjects in the genetic sub-study of AHeFT suggests that the GNB3 TT genotype, found in 50% of African Americans but only 10-15% of whites, was linked to an enhanced therapeutic response to FDC I/H. This investigation will evaluate the hypothesis that the GNB3 TT genotype is a marker of enhanced therapeutic response to FDC I/H in African Americans with HFrEF.

The study will enroll a cohort of 500 African Americans with HFrEF, initiate therapy with FDC I/H and follow them for up to two years. Subjects will be genotyped at entry for the GNB3 polymorphism and response to therapy compared by genotype. Therapeutic response will be quantified using the composite score, the primary endpoint of AHeFT, which incorporates mortality, heart failure hospitalizations, and a change in quality of life (QoL) score at six months.

Aim 2 will do a similar analysis of response to therapy by GNB3 genotype using improvement in left ventricular end diastolic diameter (LVEDD) or left ventricular ejection fraction (LVEF) by echocardiogram after six months on therapy as the outcomes measure. Aim 3 will use admixture analysis to determine first how global ancestry (the % African ancestral DNA for an individual) impacts on the outcome measures of drug response, and how the global ancestry acts as a modifier for the effect of GNB3.

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Eligibility Criteria

Inclusion Criteria:

18 years and older
History of heart failure with an LVEF (less than OR equal to) < 0.35 for at least 6 months OR an LVEF < 0.45 with left ventricular internal end diastole (defined by a diameter of more than 2.9 cm per square meter of body surface area OR more than 6.5 cm on the basis of echocardiography). ** Echo must be done within 6 months of enrollment**
New York Heart Association (NYHA) Class II-IV
Background heart failure therapy that includes angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARBs), and beta blockers (BBs) for at least 3 months (or documentation of intolerance to ACEi/ARBs and BBs)
Self-designated race as African American or black (would include subjects whose country of origin was outside the USA such as Africa, the Caribbean, or Central America).

Exclusion Criteria:

History of intolerance to either nitrates or hydralazine
Treatment with the combination of hydralazine and nitrates for the previous 3 months
Revascularization or myocardial infarction within last 90 days
Received cardiac resynchronization therapy (CRT) AND did not have an assessment of cardiac function documenting an LVEF < 35% (less than OR equal to 35%) at least 90 days post CRT
Presence of clinically significant valvular heart disease, hypertrophic or restrictive cardiomyopathy, active myocarditis, or uncontrolled hypertension. (Note that uncontrolled hypertension is defined as blood pressure consistently greater than 160 mmHg systolic and 95 mmHg diastolic)
Women who are currently pregnant, planning on becoming pregnant in the next two years, or those who do not agree to prevent pregnancy.
Subjects who are on continuous home inotropes, a left ventricular assist device, or who are post cardiac transplant.

Study is for people with:

Heart Failure

Estimated Enrollment:

225

Study ID:

NCT02305095

Recruitment Status:

Completed

Sponsor:

University of Pittsburgh

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There are 19 Locations for this study

See Locations Near You

University of Alabama Medical Center
Tuscaloosa Alabama, 35401, United States
Morehouse School of Medicine
Atlanta Georgia, 30310, United States
Emory University
Atlanta Georgia, 30322, United States
Northwestern University
Chicago Illinois, 60611, United States
University of Illinois of Chicago
Chicago Illinois, 60612, United States
Tulane University Heart and Vascular Institute
New Orleans Louisiana, 70112, United States
Ochsner
New Orleans Louisiana, 70121, United States
University of Maryland Medical Center
Baltimore Maryland, 21201, United States
Massachsetts General Hospital
Boston Massachusetts, 02113, United States
Henry Ford Health System
Detroit Michigan, 48202, United States
Rutgers University Health Center
Newark New Jersey, 07102, United States
Montefiore Medical Center Bronx New York
Bronx New York, 10461, United States
MetroHealth System
Cleveland Ohio, 44109, United States
Temple University Medical Center
Philadelphia Pennsylvania, 19140, United States
University of Pittsburgh Medical Center
Pittsburgh Pennsylvania, 15213, United States
University of South Carolina
Charleston South Carolina, 29425, United States
Stern Cardiovascular Foundation
Germantown Tennessee, 38138, United States
Baylor College of Medicine
Houston Texas, 77030, United States
University of Virginia
Charlottesville Virginia, 22903, United States

How clear is this clinincal trial information?

Study is for people with:

Heart Failure

Estimated Enrollment:

225

Study ID:

NCT02305095

Recruitment Status:

Completed

Sponsor:


University of Pittsburgh

How clear is this clinincal trial information?

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