Heart Failure Clinical Trial
LYmphangiogenesis FacTors in Heart Failure States
Summary
Heart failure often causes fluid to accumulate in the body, leading to congestion and swelling. However, some people who have had heart failure for a long time seem to have very little congestion or swelling, even when the heart failure is poorly treated. The investigators think that this is because lymphatic vessels are able to grow and remove fluid to prevent congestion. The investigators do not know how lymphatic vessels grow. This study will investigate the blood levels of various proteins to try to figure out how the lymph vessels of people with long-standing heart failure might grow.
Eligibility Criteria
Inclusion Criteria:
Undergoing clinically indicated right heart catheterization.
Exclusion Criteria:
Unable to provide consent.
Use of medications which may alter lymphangiogenesis factor expression within 365 days
Thalidomide, lenalidomide, pomalidomide
Bevacizumab
Any cytotoxic chemotherapy agents
Pregnant
Any potentially pregnant patient (based on age and gender) undergoes Beta Human chorionic gonadotropin testing as standard of care prior to any right heart catheterization.
Active cancer within 365 days
Diagnosis of familial or secondary lymphedema
Treatment of active bacterial infection within 7 days
Active inflammatory rheumatologic disease requiring anti-inflammatory therapy administration within 60 days
Conditions
Systemic lupus erythematosus
Rheumatoid arthritis
Scleroderma
Inflammatory myositis
Vasculitis
Behcet's disease
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There are 2 Locations for this study
Charleston South Carolina, 29401, United States
Charleston South Carolina, 29425, United States
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