Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy

Inclusion Criteria:

Patient provides written authorization and/or consent per institution and geographical requirements
Male or non-pregnant female, aged 18 or older
Left ventricular ejection fraction of 25-45% (inclusive, per site assessment)
NYHA Class III heart failure symptoms
Stated willingness to comply with all study procedures and availability for the duration of the study
Patient has been treated with guideline-directed medical therapy

Exclusion Criteria:

Primary heart failure due to uncorrected mitral valve disease, or mitral valve repair or clip within 90 days of implant
IV inotropes, hemofiltration, or any form of positive inotropic support within 30 days prior to implant
Myocardial infarction within 90 days prior to implant
Undergone a CABG procedure within 90 days or a PTCA procedure within 30 days of implant
Prior heart transplant or ventricular assist device
Mechanical tricuspid valve
Receiving cardiac resynchronization therapy (CRT) or has a Class I indication for CRT implantation according to the ACCF/AHA/HRS guidelines for device-based therapy
Participating in a cardiac investigational study at the same time
Patient is in a vulnerable population (such as significant mental disability, prisoner) that in the judgement of the PI impedes ability to provide informed consent.